Behçet Hastalığında Nabız Dalga Hızı Aracılığı ile Değerlendirilen Azalmış Arteriyel Elastisite

Year 2019, Volume: 22 Issue: 2, 96 - 99, 15.08.2019

Mustafa Bulut Uğur Arslantaş

Abstract

Giriş: Behçet
hastalığı, nadir görülen kronik bir hastalıktır. Başlıca histopatolojik lezyonu
vaskülittir. Nabız dalga hızı aortik sertliğin göstergesi olup arteriyel
distansibilite, elastisite ve göreceli arteriyel kompliyansla ters yönde
ilişkilidir. Mevcut çalışmada; Behçet hastalığına sahip hastalarda nabız dalga
hızı aracılığı ile ölçülen arteriyel elastisite araştırılmıştır.

 

Hastalar ve Yöntem:
Daha önce bilinen hipertansiyon, diabetes mellitus, hiperlipidemi gibi
geleneksel kardiyovasküler risk faktörü olmayan 25 (21 erkek) Behçet hastası ve
21 (10 erkek) sağlıklı birey çalışmaya alındı. Ortalama hastalık süresi 3.6 ±
2.5 (1-10) yıldı. Arteriyel elastisite, otomatik olarak karotis-femoral
(aortik) nabız dalga hızı aracılığıyla Complior Colson (Fransa) cihazı ile
değerlendirildi. Nabız dalga hızı; Nabız dalga hızı (m/s) = mesafe (m)/ilerleme
zamanı (s) formülü ile hesaplandı.

 

Bulgular:
Karotis-femoral (aortik) nabız dalga hızı (10.66 ± 1.74; 8.16 ± 0.84 m/s) ve
diyastolik kan basıncı (79.00 ± 10.10; 73.33 ± 8.11 mmHg) kontrol grubuna göre
Behçet hastalığında daha yüksek bulundu (sırası ile p< 0.001, p= 0.03).
Sadece nabız dalga hızı ile yaş, diyastolik kan basıncı ve ortalama kan basıncı
arasında anlamlı korelasyon saptandı (sırası ile p< 0.001, r= 0.56; p= 0.02,
r= 0.32; p= 0.03, r= 0.31).

 

Sonuç: Arteriyel
sertlik ve aterosklerozun bir belirteci olan karotis-femoral (aortik) nabız
dalga hızı aracılığı ile değerlendirilen arteriyel elastisite sağlıklı
kontrollere göre Behçet hastalığında azalmış olarak bulunmuştur.

Keywords

Behçet hastalığı, nabız dalga hızı

Decreased Arterial Elasticity Assessed by Pulse Wave Velocity in Patients with Behçet’s Disease

Abstract

Introduction:
Behçet’s disease (BD) is a rare chronic disorder. The predominant histopathological
lesion is vasculitis. Pulse wave velocity (PWV) is a marker of aortic stiffness
and inversely related to arterial distensibility, elasticity, or relative
arterial compliance. The aim of the present study was to investigate the
arterial elasticity using PWV in patients with BD.

 

Patients and Methods:
A total of 25 patients with BD (21 male) and 21 healthy subjects (10 male)
without known traditional cardiovascular risk factors, such as hypertension,
diabetes mellitus, and hyperlipidemia, were studied. The mean time of disease
duration was 3.6 ± 2.5 (1-10) years. Arterial elasticity was assessed by
automatic carotid-femoral (aortic) PWV measurement by the Complior Colson
(France) device. PWV is calculated by the following formula: Pulse wave velocity
(m/s) = distance (m)/transit time (s).

 

Results: The
carotid-femoral (aortic) PWV (10.66 ± 1.74 vs. 8.16 ± 0.84 m/s) and diastolic
blood pressure (79.00 ± 10.10 vs. 73.33 ± 8.11 mmHg) were higher in patients
with BD than in the control groups (p< 0.001 and p= 0.03, respectively). A
significant correlation was found between PWV and age, diastolic blood
pressure, and mean blood pressure in the studied group (p< 0.001, r= 0.56;
p= 0.02, r= 0.32; and p= 0.03, r= 0.31, respectively).

 

Conclusion: Arterial
elasticity assessed by carotid-femoral (aortic) PWV, an indicator of arterial
stiffness and atherosclerosis, is lower in patients with BD than in healthy
controls.

Keywords

Behçet’s disease, pulse wave velocity

References

• 1. Protogerou AD, Nasothimiou EG, Sfikakis PP, Tzioufas AG. Non-invasive vascular biomarkers in patients with Behçet’s disease: review of the data and future perspectives. Clin Exp Rheumatol 2017;35 Suppl 108:100-7.
• 2. Upala S, Yong WC, Sanguankeo A. Increased arterial stiffness in Behçet’s disease: a systematic review and meta-analysis. Korean Circ J 2017;47:477-82.
• 3. O’Duffy JD. Vasculitis in Behçet’s disease. Rheum Dis Clin North Am 1990;16:423-31.
• 4. Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, et al. Assessment of arterial distensability by automatic pulse wave velocity measurement: validation and clinical application studies. Hypertension 1995;26:485-90.
• 5. Bonarjee VVS. Arterial stiffness: a prognostic marker in coronary heart disease. Available Methods and Clinical Application. Front Cardiovasc Med 2018;5:64.
• 6. Oh YS. Arterial stiffness and hypertension. Clin Hypertens 2018;24:17.
• 7. Hatemi G, Christensen R, Bang D, Bodaghi B, Celik AF, Fortune F, et al. 2018 update of the EULAR recommendations for the management of Behçet’s syndrome. Ann Rheum Dis 2018;77:808-18.
• 8. Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, et al. [2018 ESC/ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH)]. G Ital Cardiol (Rome) 2018;19:3-73.
• 9. Yildiz M. Arterial distensibility in chronic inflammatory rheumatic disorders. Open Cardiovasc Med J 2010;4:83-8.
• 10. Čypienė A, Dadonienė J, Miltinienė D, Rinkūnienė E, Rugienė R, Stropuvienė S, et al. The fact not to ignore: mean blood pressure is the main predictor of increased arterial stiffness in patients with systemic rheumatic diseases. Adv Med Sci 2017;62:223-9.
• 11. Kheder-Elfekih R, Yannoutsos A, Blacher J, London GM, Safar ME. Hypertension and chronic kidney disease: respective contribution of mean and pulse pressure and arterial stiffness. J Hypertens 2015;33:2010-5.
• 12. Sebban C, Berthaux P, Lenoir H, Eugene M, Venet R, Memin Y, et al. Arterial compliance, systolic pressure and heart rate in elderly women at rest and on exercise. Gerontology 1981;27:271-80.
• 13. Zhou TL, Henry RMA, Stehouwer CDA, van Sloten TT, Reesink KD, Kroon AA. Blood pressure variability, arterial stiffness, and arterial remodeling. Hypertension 2018;72:1002-10.
• 14. Olivetti G, Anversa P, Melissari M, Loud AV. Morphometry of medial hypertrophy in the rat thoracic aorta. Lab Invest 1980;42:559-65.