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Role of Mean Platelet Volume in the Development of Peripheral Artery Disease

Year 2020, Volume: 23 Issue: 2, 91 - 94, 16.08.2020

Abstract

Introduction: The mean platelet volume (MPV) is one of several indicators of platelet activity. Recent studies have shown that MPV is increased in myocardial infarction, unstable angina, and stroke. Peripheral artery disease (PAD) manifests with the narrowing or obstruction of the abdominal aorta and arteries distal to the aortic bifurcation due to progressive atherosclerosis. The objective of this study is to investigate the MPV and platelet count in patients with PAD.

Patients and Methods: This study included 67 patients aged 40-80 years who underwent elective surgery for PAD in our hospital between January 2018 and June 2019, along with a control group comprising 67 patients without PAD. The MPV and platelet count values were obtained from a preoperatively performed hemogram analysis. Importantly, the groups were statistically compared in our study.

Results: As compared to the control group, the patients with PAD had a significantly higher mean age (p= 0.02), prevalence of diabetes mellitus (p< 0.01), as well as frequency of antiaggregant use (p< 0.01) and smoking (p< 0.01). There were no statistically significant differences in the other clinical features between the groups (p> 0.05). The mean platelet count and MPV were also significantly higher in patients with PAD as compared to patients without PAD (p< 0.01).

Conclusion: The use of inexpensive and widely used tests such as platelet count and MPV can facilitate an early diagnosis of the diseases with high morbidity and mortality, such as PAD.

References

  • 1. Bath PMW, Butterworth RJ. Platelet size: measurement, physiology and vasculer disease. Blood Coag Fibrinolysis 1996;7:157-61.
  • 2. Kalkan GY, Gür M, Baykan AO, Uçar H, Elbasan Z, Şahin DY, et al. Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease. Anatol J Cardiol 2015;15:753-8.
  • 3. Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arterioscler Thromb Vasc Biol 2011;31:1215-8.
  • 4. D’ Erasmo E, Aliberti G, Celi FS. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 1990;227:11-4.
  • 5. Demirtaş S, Karahan O, Yazıcı S, Güçlü O, Çalışkan A, Yavuz C, et al. The relationship between complete blood count parameters and Fontaine’s Stages in patients with peripheral arterial disease. Vascular 2014;22:427-31.
  • 6. Madjid M, Fatemi O. Companents of the complete blood count as risk predictors for coronary heart disease: in-depth rewiew and update. Tex Heart Inst J 2013;40:17-29.
  • 7. Kaya H, Ertaş F, İslamoğlu Y, Kaya Z, Arıtürk Atılgan Z, Çil H, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014;20:50-4.
  • 8. Zeiger F, Stephan S, Hoheisel G, Pfeiffer D, Ruehlmann C, Koksch M. P-selection expression, platelet aggregates, and platelet-derived microparticle formation are increased in peripheral arterial disease. Blood Coagul Fibrinolysis 2000;11:723-8.
  • 9. Rief P, Raggam BR, Avian A, Hafner F, Sareban M, Wehrschuetz M, et al. Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease. Sci Rep 2018;8:6718.
  • 10. Özlük AÖ, Ber İ, Peker T, Yılmaz M, Tenekecioğlu E, Karaağaç K, Vatansever F. Mean platelet volume levels in the presence of angiographically documented peripheral artery disease. Int J Clin Exp Med 2015;8:2899-904.
Year 2020, Volume: 23 Issue: 2, 91 - 94, 16.08.2020

Abstract

References

  • 1. Bath PMW, Butterworth RJ. Platelet size: measurement, physiology and vasculer disease. Blood Coag Fibrinolysis 1996;7:157-61.
  • 2. Kalkan GY, Gür M, Baykan AO, Uçar H, Elbasan Z, Şahin DY, et al. Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease. Anatol J Cardiol 2015;15:753-8.
  • 3. Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arterioscler Thromb Vasc Biol 2011;31:1215-8.
  • 4. D’ Erasmo E, Aliberti G, Celi FS. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 1990;227:11-4.
  • 5. Demirtaş S, Karahan O, Yazıcı S, Güçlü O, Çalışkan A, Yavuz C, et al. The relationship between complete blood count parameters and Fontaine’s Stages in patients with peripheral arterial disease. Vascular 2014;22:427-31.
  • 6. Madjid M, Fatemi O. Companents of the complete blood count as risk predictors for coronary heart disease: in-depth rewiew and update. Tex Heart Inst J 2013;40:17-29.
  • 7. Kaya H, Ertaş F, İslamoğlu Y, Kaya Z, Arıtürk Atılgan Z, Çil H, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014;20:50-4.
  • 8. Zeiger F, Stephan S, Hoheisel G, Pfeiffer D, Ruehlmann C, Koksch M. P-selection expression, platelet aggregates, and platelet-derived microparticle formation are increased in peripheral arterial disease. Blood Coagul Fibrinolysis 2000;11:723-8.
  • 9. Rief P, Raggam BR, Avian A, Hafner F, Sareban M, Wehrschuetz M, et al. Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease. Sci Rep 2018;8:6718.
  • 10. Özlük AÖ, Ber İ, Peker T, Yılmaz M, Tenekecioğlu E, Karaağaç K, Vatansever F. Mean platelet volume levels in the presence of angiographically documented peripheral artery disease. Int J Clin Exp Med 2015;8:2899-904.
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Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Investigations
Authors

Dilek Mersin This is me 0000-0001-8091-9997

Bedih Balkan This is me 0000-0003-3510-6991

Ünal Aydın This is me 0000-0001-6635-108X

Publication Date August 16, 2020
Published in Issue Year 2020 Volume: 23 Issue: 2

Cite

Vancouver Mersin D, Balkan B, Aydın Ü. Role of Mean Platelet Volume in the Development of Peripheral Artery Disease. Koşuyolu Heart Journal. 2020;23(2):91-4.