Protective Effects of Melatonin and Its Supplements on the Arterial Mechanics

Year 2022, Volume: 25 Issue: 2, 213 - 215, 20.08.2022

Mustafa Yıldız Banu Şahin Yıldız

Abstract

Melatonin (5-methoxy-N-acetyltryptamine), a neurohormone, is synthesized from tryptophan taken up by the pineal gland cells. It affects several cardiovascular functions such as arterial blood pressure, heart rate, cardiac rhythms, and mechanical properties of the large arteries and aorta. Melatonin and its supplements, generally made in a laboratory, can improve several cardiovascular functions such as arterial blood pressure and arterial mechanics.

Keywords

Melatonin, supplement, arterial mechanics

References

• 1. Cipolla-Neto J, Amaral FGD. Melatonin as a hormone: New physiological and clinical ınsights. Endocr Rev 2018;39:990-1028. [Crossref]
• 2. Drijfhout WJ, van der Linde AG, Kooi SE, Grol CJ, Westerink BH. Norepinephrine release in the rat pineal gland: The input from the biological clock measured by in vivo microdialysis. J Neurochem 1996;66:748-55. [Crossref]
• 3. Benítez-King G, Ríos A, Martínez A, Antón-Tay F. In vitro inhibition of Ca2+/calmodulin-dependent kinase II activity by melatonin. Biochim Biophys Acta 1996;1290:191-6. [Crossref]
• 4. Baltatu O, Afeche SC, José dos Santos SH, Campos LA, Barbosa R, Michelini LC, et al. Locally synthesized angiotensin modulates pineal melatonin generation. J Neurochem 2002;80:328-34. [Crossref]
• 5. Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, et al. Update on melatonin receptors: IUPHAR Review 20. Br J Pharmacol 2016;173:2702-25. [Crossref]
• 6. Drew JE, Williams LM, Hannah LT, Barrett P, Abramovich DR. Melatonin receptors in the human fetal kidney: 2-[125I]iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes. J Endocrinol 1998;156:261-7. [Crossref]
• 7. Torres-Farfan C, Richter HG, Rojas-García P, Vergara M, Forcelledo ML, Valladares LE, et al. mt1 Melatonin receptor in the primate adrenal gland: Inhibition of adrenocorticotropin-stimulated cortisol production by melatonin. J Clin Endocrinol Metab 2003;88:450-8. [Crossref]
• 8. Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT. Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol Cell Endocrinol 2012;351:152-66 [Crossref]
• 9. Yildiz M. Melatonin modulation of vasculare structure and function. Melatonin in the promotion of health. In: Watson RR (ed.), 2012, FL. CRC Press, pp. 489-93.
• 10. Repová-Bednárová K, Aziriová S, Hrenák J, Krajčírovičová K, Adamcová M, Paulis L, et al. Effect of captopril and melatonin on fibrotic rebuilding of the aorta in 24 hour light-induced hypertension. Physiol Res 2013;62(Suppl 1):S135-41. [Crossref]
• 11. Yıldız M, Soy M, Kurum T, Ozbay G. Increased pulse wave velocity and shortened pulse wave propagation time in young patients with rheumatoid arthritis. Can J Cardiol 2004;20:1097-100.
• 12. Yıldız M, Masatlioglu S, Seymen P, Aytac E, Sahin B, Seymen HO. The carotid-femoral (aortic) pulse wave velocity as a marker of arterial stiffness in familial Mediterranean fever. Can J Cardiol 2006;22:1127-31. [Crossref]
• 13. Yildiz M, Altun A, Ozbay G. Assessment of arterial distensibility in patients with cardiac syndrome X. Angiology 2007;58:458-62. [Crossref]
• 14. Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement: Validation and clinical application studies. Hypertension 1995;26:485-90 [Crossref]
• 15. Yildiz M. Arterial distensibility in chronic inflammatory rheumatic disorders. Open Cardiovasc Med J 2010;4:83-8. [Crossref]
• 16. Vanhoutte PM, Shimokawa H, Feletou M, Tang EH. Endothelial dysfunction and vascular disease-A 30th anniversary update. Acta Physiol 2017;219:22-96. [Crossref]
• 17. Pechanova O, Paulis L, Simko F. Peripheral and central effects of melatonin on blood pressure regulation. Int J Mol Sci 2014;15:17920-37. [Crossref]
• 18. Sahna E, Parlakpinar H, Turkoz Y, Acet A. Protective effects of melatonin on myocardial ischemia/reperfusion induced infarct size and oxidative changes. Physiol Res 2005;54:491-5.
• 19. Dominguez-Rodriguez A, Abreu-Gonzalez P, Reiter RJ. Melatonin and cardiovascular disease: Myth or reality? Rev Esp Cardiol 2012;65: 215-18. [Crossref]
• 20. Yildiz BS, Sahin A, Aladag NB, Yildiz M. Association of endogenous melatonin with uric acid and traditional cardiovascular risk factors in healthy young male. Adv Clin Exp Med 2015;24:233-7. [Crossref]
• 21. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA 2009;106:4453-8. [Crossref]
• 22. Aso Y. Plasminogen activator inhibitor (PAI)-1 in vascular inflammation and thrombosis. Front Biosci 2007;12:2957-66. [Crossref]
• 23. Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med Rev 2005;9:11-24. [Crossref]
• 24. Yildiz M, Akdemir O. Assessment of the effects of physiological release of melatonin on arterial distensibility and blood pressure. Cardiol Young 2009;19:198-203. [Crossref]
• 25. Nishiyama K, Yasue H, Moriyama Y, Tsunoda R, Ogawa H, Yoshimura M, et al. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. Am Heart J 2001;141(5):E9. [Crossref]
• 26. Yildiz M, Sahin B, Sahin A. Acute effects of oral melatonin administration on arterial distensibility, as determined by carotid-femoral pulse wave velocity, in healthy young men. Exp Clin Cardiol 2006;11:311-3.
• 27. Obayashi K, Saeki K, Kurumatani N. Association between urinary 6-sulfatoxymelatonin excretion and arterial stiffness in the general elderly population: The HEIJO-KYO cohort. J Clin Endocrinol Metab 2014;99:3233-9. [Crossref]
• 28. Lemley CO, Meyer AM, Camacho LE, Neville TL, Newman DJ, Caton JS, et al. Melatonin supplementation alters uteroplacental hemodynamics and fetal development in an ovine model of intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol 2012;302:R454-67. [Crossref]
• 29. McCarty KJ, Owen MPT, Hart CG, Thompson RC, Burnett DD, King EH, et al. Effect of chronic melatonin supplementation during mid to late gestation on maternal uterine artery blood flow and subsequent development of male offspring in beef cattle. J Anim Sci 2018;96:5100-11. [Crossref]
• 30. Chaudagar KK, Viczenczova C, Szeiffova Bacova B, Egan Benova T, Barancik M, Tribulova N. Modulation of systemic and aortic nitric oxide by melatonin and n-3 polyunsaturated fatty acids in isoproterenol affected spontaneously hypertensive and normotensive Wistar rats. Physiol Res 2016;65 Suppl 1:S109- 18. [Crossref]
• 31. Brockus KE, Hart CG, Gilfeather CL, Fleming BO, Lemley CO. Dietary melatonin alters uterine artery hemodynamics in pregnant Holstein heifers. Domest Anim Endocrinol 2016;55:1-10. [Crossref]
• 32. Kim Y, Kang HT, Lee DC. Melatonin supplementation for six weeks had no effect on arterial stiffness and mitochondrial DNA in women aged 55 years and older with insomnia: A double-blind randomized controlled study. Int J Environ Res Public Health 2021;18(5):2561. [Crossref]