Impact of Disulfide/Thiol Redox Couple on Pulse Wave Velocity in Patients with Normal Coronary Angiography

Year 2023, Volume: 26 Issue: 2, 76 - 82, 12.07.2023

Selahattin Akyol Hazar Harbalıoğlu Mustafa Gür Özcan Erel Hakim Çelik

Abstract

Introduction: The oxidized thiol/disulfide couple has been investigated and reported as a potential risk factor for cardiovascular diseases. Additionally, an increased pulse wave velocity has been identified as a predictor of cardiovascular events.

Patients and Methods: 262 patients were included in our study. Native and total thiol levels, total disulfide levels, disulfide per total thiol ratios, native thiol per total thiol ratios, and disulfide per native thiol level ratios were calculated.

Results: Patients were divided into Pulse Wave Velocity (PWV) low and PWV high groups. Native and total thiol levels were higher in PWV low group compared to PWV high group (p< 0.001 for both). The median disulfide value was higher in PWV high group (p= 0.002). Disulfide per native thiol and disulfide per total thiol ratio values were higher in PWV high group (p< 0.001). Native thiol per total thiol ratios were higher in the PWV-low group (p< 0.001).

Conclusion: The disulfide/native thiol pathway may be an indicator for predicting future atherosclerotic cardiovascular events.

Keywords

Antioxidant, thiol, antioxidants

References

• 1. Turell L, Radi R, Alvarez B. The thiol pool in human plasma: The central contribution of albumin to redox processes. Free Radic Biol Med 2013;65:244-53. [Crossref]
• 2. Cremers CM, Jakob U. Oxidant sensing by reversible disulfide bond formation. J Biol Chem 2013;37:26489-96.
• 3. Jaganjac M, Cipak A, Schaur RJ, Zarkovic N. Pathophysiology of neutrophil-mediated extracellular redox reactions. Front Biosci 2016;21:839-55. [Crossref]
• 4. Gür M, Elbasan Z, Yıldıray Şahin D, Yıldız Koyunsever N, Seker T, Ozaltun B, et al. DNA damage and oxidative status in newly diagnosed, untreated, dipper and non-dipper hypertensive patients. Hypertens Res 2013;2:166-71. [Crossref]
• 5. Kundi H, Erel Ö, Balun A, Çiçekçioğlu H, Cetin M, Kiziltunç E, et al. Association of thiol/disulfide ratio with syntax score in patients with NSTEMI. Scand Cardiovasc J 2015;2:95-100. [Crossref]
• 6. Jones DP, Carlson JL, Mody VC, Cai J, Lynn MJ, Sternberg P. Redox state of glutathione inhuman plasma. Free Radic Biol Med 2000;28:625- 35. [Crossref]
• 7. Go YM, Jones DP. Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med 2011;4:495-509.
• 8. Cohn JN. Vascular wall function as a risk marker for cardiovascular disease. J Hypertens Suppl 1999;5:41-4. [Crossref]
• 9. Akkus O, Sahin DY, Bozkurt A. Evaluation of arterial stiffness for predicting futurecardiovascular events in patients with ST segment elevation and non-ST segmentelevation myocardial infarction. Sci World J 2013;2013:792693. [Crossref]
• 10. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2007;25:1105-87.
• 11. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. [Crossref]
• 12. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, et al. Recommendations for quantitation of the left ventricle by two- dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of TwoDimensional Echocardiograms. J Am Soc Echocardiogr 1989;5:358-67. [Crossref]
• 13. Wassertheurer S, Kropf J, Weber T, van der Giet M, Baulmann J, Ammer M, et al. A new oscillometric method for pulse wave analysis: Comparison with a common tonometric method. J Hum Hypertens 2010;24:498-504. [Crossref]
• 14. Liu WJ, Wang T, Wang B, Liu XT, He XW, Liu YJ, et al. CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation. J Huazhong Univ Sci Technolog Med Sci 2015;5:640-5. [Crossref]
• 15. Antoniak DT, Duryee MJ, Mikuls TR, Thiele GM, Anderson DR. Aldehyde-modified proteins as mediators of early inflammation in atherosclerotic disease. Free Radic Biol Med 2015;89:409-18. [Crossref]
• 16. Kirlin WG, Cai J, Thompson SA, Diaz D, Kavanagh TJ, Jones DP. Glutathione redox potential in response to differantiation and enzyme inducers. Free Radic Biol Med 1999;11:1208-18. [Crossref]
• 17. Nkabyo YS, Ziegler TR, Gu LH, Watson WH, Jones DP. Glutathione thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells. Am J Physiol Gastrointest Liver Physiol 2002;6:1352-9. [Crossref]
• 18. Bouchareychas L, Pirault J, Saint-Charles F, Deswaerte V, Le Roy T, Jessup W, et al. Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE. Cardiovasc Res 2015;1:111-23. [Crossref]
• 19. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010;6:749-62.
• 20. Ates I, Kaplan M, Yuksel M, Mese D, Alisik M, Erel Ö, et al. Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation. Endocrine 2016;51:47-51. [Crossref]
• 21. Dirican N, Dirican A, Sen O, Aynali A, Atalay S, Bircan HA, et al. Thiol/ disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer? Redox Rep 2016;21:197-203. [Crossref]
• 22. Ateş İ, Özkayar N, Altay M, Yilmaz FM, Topçuoğlu C, Alışık M, et al. Is disulphide/thiol ratio related to blood pressure in masked hypertension? Clin Exp Hypertens 2015;29:1-5. [Crossref]
• 23. Kundi H, Ates I, Kiziltunc E, Cetin M, Cicekcioglu H, Neselioglu S, et al. A novel oxidative stress marker in acute myocardial infarction; thiol/ disulphide homeostasis. Am J Emerg Med 2015;11:1567-71. [Crossref]
• 24. Shin JH, Lee Y, Kim SG, Choi BY, Lee HS, Bang SY. The beneficial effects of Tai Chi exercise on endothelial function and arterial stiffness in elderly women with rheumatoid arthritis. Arthritis Res Ther 2015;1:380. [Crossref]
• 25. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005;25:932- 43. [Crossref]
• 26. Blacher J, Safar ME, Guerin AP, Pannier B, Marchais SJ, London GM. Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int 2003;63:1852-60. [Crossref]
• 27. Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: A longitudinal study. Hypertension 2002;39:10-5. [Crossref]
• 28. Mc Clean Mc Clean CM, Mc Laughlin J, Burke G, Murphy MH, Trinick T, Duly E, et al. The effect of acute aerobic exercise on pulse wave velocity and oxidative stress following postprandial hypertriglyceridemia in healthy men. Eur J Appl Physiol 2007;2:225-34. [Crossref]
• 29. Patel RS, Al Mheid I, Morris AA, Ahmed Y, Kavtaradze N, Ali S, et al. Oxidative stress is associated with impaired arterial elasticity. Atherosclerosis 2011;1:90-5. [Crossref]
• 30. Sharman JE, Gunaruwan P, Knez WL, Schmitt M, Marsh SA, Wilson GR, et al. Alpha-lipoic acid does not acutely affect resistance and conduit artery function or oxidative stress in healthy men. Br J Clin Pharmacol 2004;3:243-8. [Crossref]