Examining The Relationship Between Lateral Ventricle Volumetric Index and Linear Indexes in Childhood and Adolescence: A Retrospective MRI Study

Year 2024, , 62 - 68, 23.08.2024

Sefa Işıklar , Dilek Sağlam

https://doi.org/10.52831/kjhs.1505514

Abstract

Objective: Indexes obtained from two-dimensional and three-dimensional measurements are used to evaluate the brain's lateral ventricle (LV) structure. However, there were limited studies on how well the Evans index (EI) and the Bicaudate index (BI), which estimate LV volume, represent the LV volumetric index (LVVI) in the childhood and adolescence period. This study investigated the relationship between LVVI and linear indexes (EI and BI) in the pediatric period regarding age and sex factors.
Method: This study was performed retrospectively in 588 individuals (267 [45.4%] females) aged 1-18 years with normal brain magnetic resonance images (MRI) between 2012 and 2021. LVVI was obtained by segmenting three-dimensional T1-weighted MRIs with volBrain1.0. LVVI was obtained by dividing the LV absolute volume by the total intracranial volume. We made linear measurements for EI and BI with the 3D Slicer. In this study, we compared the data obtained from individuals in 16 different age ranges between 1-18 years old with SPSS (ver.28).
Results: In our study, we found the mean value of LVVI to be 0.656±0.372%. The mean values of EI and BI were 0.242±0.025 and 0.070±0.022, respectively. In the pediatric population, we found that mean values of EI and BI were significantly higher in males than in females (p<0.05). In the pediatric period, LVVI had a positive correlation with EI at a moderate level (r:0.443) and with BI at a high level (r:0.624) (p<0.001).
Conclusion: In this study, we presented LVVI data to evaluate LV in the pediatric period. This study showed that using BI instead of EI is more effective in estimating LV volume when LVVI information is unavailable in the pediatric period.

Keywords

Lateral ventricles, Index, Three-Dimensional Imaging, Child, Adolescent

Ethical Statement

The local ethics committee approved the conduct of this study (Bursa Uludag University Faculty of Medicine Clinical Research Ethics Committee, Approval Date: 19.09.2023 Decision Number: 2023-17/20).

Thanks

We want to thank Prof. Güven Özkaya (Bursa Uludağ University Faculty of Medicine, Department of Biostatistics) for his consultancy for the statistical analysis of our study.

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