Cytotoxin Associated Gene A+ Helicobacter pylori Infection is Related with Endothelial Dysfunction in Normotensive Individuals

Abstract

OBJECTIVE: Cytotoxin associated gene (Cag) A+ Helicobacter pylori (HP) is the most virulent HP strain, and its association with endothelial dysfunction remains unclear. Thus we investigated the effects of CagA+ HP on endothelial dependent dilatation and its relationship with C-reactive protein (CRP) in normotensive subjects. METHODS: Sixty individuals with CagA+ HP infection were compared with 40 individuals with CagA(-) HP infection and 50 individuals with no infection in terms of flow-mediated dilatation (FMD), non-endothelium-dependent dilatation (NED) and CRP.RESULTS: In the CagA+ subjects the mean percentage of FMD was 6.3±2.7, which was significantly lower than that of the CagA- subjects (9.8±3.3, p

Keywords

• Cytotoxine associated gene A protein, Helicobacter pylori; flow-mediated dilatation

Sitotoksin İlişkili A+ Genli Helicobacter pylori Enfeksiyonu Normotansif Bireylerde Endotelyal Disfonksiyon ile İlişkilidir

Abstract

AMAÇ: Sitotoksin ilişkili A genli Helicobacter pylori (SİAGHP), en çok virülansı olan H. pylori tipidir ve halen endotelyal disfonksiyon ile ilişkisi belirsizdir. Bu nedenle biz SİAGHP'nin endotelyal bağımlı dilatasyon üzerine etkilerini ve C-reaktif protein (CRP) düzeyleri ile ilişkisini normotansif bireylerde araştırdık.YÖNTEMLER: SİAGHP enfeksiyonu olan 60 kişi, sitotoksin ilişkili A geni negatif H. pylori (SAİGNHP) enfeksiyonlu 40 kişi ve enfeksiyonu olmayan 50 kişi ile akım aracılı dilatasyon (AAD), endotele bağımlı olmayan dilatasyon (EBOD) ve CRP düzeyleri yönünden karşılaştırıldı.BULGULAR: SİAGHP'li bireylerde ortalama AAD'nin yüzdesi (6.3±2.7) SİAGNHP olanlardan (9.8±3.3, p

Keywords

• Sitotoksin ilişkili gen A protein, Helicobacter pylori; akım aracılı dilatasyon

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