Can Embolic Events Be Predicted by the Properties of Vegetation in Infective Endocarditis? A Single Center Experience

Abstract

OBJECTIVE: We aimed to investigate the predisposing factors of embolic events and the role of vegetation properties on the embolic complications for infective endocarditis (IE).METHODS: The archive records of 119 patients with a definite diagnosis of IE between January 1997 and November 2004 were reviewed for clinical, echocardiographic, microbiologic properties and embolic events.RESULTS: Major arterial embolization was observed in 28 (23.5%) of 119 study patients on admission. These patients were included in the embolization group. Parameters such as culture positivity (p=0.017, 95% confidence interval (CI)=1.1-24.6) ejection fraction (EF) (p=0.003, 95% CI=1.1-1.4), presence of vegetation (p=0.013, 95% CI=1.1-1.13), size of vegetation (p=0.002, 95% CI= 1.1-2.1), vegetation mobility (p=0.01, 95% CI=2.1-24.5), and chordal rupture (p=0.041, 95% CI=1.07-7.14) were identified as significant predictors of embolization. CONCLUSION: In patients with infective endocarditis, culture positivity, EF, presence of vegetation, vegetation mobility, size of vegetation, and the presence of chordal rupture are the variables with predictive value for embolization. Further prospective controlled trials are required in order to identify the predictive value of the presented data and other variables.

Keywords

• Infective endocarditis, embolic events; vegetation

Enfektif Endokarditte Embolik Olaylar Vejetasyon Özellikleri ile Predikte Edilebilir mi? Tek Merkez Deneyimi

Abstract

AMAÇ: Kurumumuzda modifiye Duke kriterlerine göre enfektif endokardit tanısı konularak takip ve tedavi edilen 119 enfektif endokardit hastasında embolik olaylar açısından predispozan faktörlerin ve vejetasyon özelliklerinin embolik komplikasyon üzerine olan etkilerinin araştırılmasıdır.YÖNTEMLER: Kurumumuz hastane kayıtları incelenerek, Ocak 1997-Kasım 2004 tarihleri arasında başvuran ve enfektif endokardit tanısı konan 119 hasta klinik, ekokardiyografik ve mikrobiyolojik açıdan değerlendirildi.BULGULAR: Başvuru anında 119 hastanın 28 (%23.5)'inde majör arteriyel emboli gözlemlendi. Bu hastalar emboli grubunu oluşturdu. Kültür pozitifliği (p=0.017, %95 güven aralığı (GA)=1.1-24.6), ejeksiyon fraksiyonu (EF) (p=0.003, %95 GA=1.1-1.4), vejetasyon varlığı (p=0.013, %95 GA=1.1-1.13), vejetasyon büyüklüğü (p=0.002, %95 GA=1.1-2.1), vejetasyon mobilitesi (p=0.01, %95 GA=2.1-24.5), ve korda rüptürü (p=0.041, %95 GA=1.07-7.14) gibi parametrelerin emboli açısından anlamlı prediktörler olduğu tespit edildi.SONUÇ: Endokardit tanılı hastalarda kültür pozitifliği, EF, vejetasyon varlığı mobilitesi ve büyüklüğü ile korda rüptürü varlığı emboli açısından prediktif değere sahip değişkenlerdir. Bu prediktif değişkenlerin ve daha başka değişkenlerin değerinin anlaşılması için daha fazla prospektif kontrollü çalışmaya ihtiyaç vardır.

Keywords

• Enfektif endokardit, embolik olaylar; vejetasyon

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