Levosimendan Improves NT-proBNP Levels and Echocardiographic Parameters in Patients with Decompensated Heart Failure Submitted to Optimal Medical Therapy

Abstract

OBJECTIVE: The effect of levosimendan on NT-proBNP levels and echocardiographic parameters in patients with decompensated heart failure receiving optimal medical therapy was evaluated.METHODS: The study included 30 patients with acute heart failure with New York Heart Association (NYHA) class IV. Although all patients had received standard heart failure therapy, they required support of an inotropic agent. They received bolus and maintenance infusion of levosimendan treatment for 24 hours. Echocardiography was performed before the levosimendan treatment and at the 5th day after the treatment. NT-proBNP levels were taken at 48th hour and 5th day.RESULTS: Levosimendan treatment (bolus+maintenance infusion) was performed in all patients without any interruption or complication. A significant reduction in NT-proBNP levels was observed at the end of 48th hour and 5th day compared to baseline values (p

Keywords

• Heart failure, levosimendan; NT-proBNP; echocardiography

Levosimendan Optimal Medikal Tedavi Alan Dekompanse Kalp Yetersizliği Hastalarında NTproBNP Seviyesini ve Ekokardiyografik Parametreleri Düzeltir

Abstract

AMAÇ: Optimal medikal tedavi alan dekompanse kalp yetersizliği hastalarında levosimendanın NT-proBNP seviyesi ve ekokardiyografik parametreler üzerindeki etkisi değerlendirilmiştir.YÖNTEMLER: Çalışmaya "New York Heart Association (NYHA)" Sınıf IV olan 30 akut kalp yetersizliği hastası dâhil edildi. Tüm hastalar standart kalp yetersizliği tedavisi almasına rağmen inotrop desteğe ihtiyaç duyuyordu. Hastalara 24 saat boyunca bolus ve idame infüzyon şeklinde levosimendan uygulandı. Levosimendan tedavisi öncesi ve tedavi sonrası 5. gün ekokardiyografi uygulandı. NT-proBNP seviyeleri 48. saat ve 5. gün çalışıldı.BULGULAR: Levosimendan tedavisi (bolus+idame) tüm hastalara kesintisiz ve komplikasyon gelişmeden verilebildi. Bazal bulgulara kıyasla 48. saat ve 5. gün sonunda NT-proBNP seviyelerinde önemli bir azalma sağlandı (p

Keywords

• Kalp yetersizliği, levosimendan; NT-proBNP; ekokardiyografi

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