Usefulness of Platelet-Lymphocyte Ratio to Predict Stent Thrombosis in Patients with ST Elevation Myocardial Infarction

Abstract

Introduction: Stent thrombosis, an iatrogenic disease, is an important complication of percutaneous coronary intervention (PCI). The platelet to lymphocyte ratio (PLR) has been recently proposed to be a marker of thrombosis and inflammation, mainly in cancer patients. The aim of this study was to determine whether PLR in patients presenting with acute ST elevation myocardial infarction (STEMI) is predictive of the development of stent thrombosis.Patients and Methods: We retrospectively analyzed the clinical, hematologic, and angiographic data of total 201 patients (mean age 59.8±13.1 years, 3 out of 4 were males) who had undergone PCI for acute STEMI and a further control coronary angiography. 54 of them were diagnosed as stent thrombosis and formed the patient group and 147 patients matched with patient group in terms of age, gender, traditional coronary risk factors, stent implantation procedure, and stent type and length formed the control group in whom the stent implanted during primary PCI was found patent in the repeat coronary angiography.Results: The pre-procedural PLR was significantly higher in patients with stent thrombosis compared to patients without stent thrombosis (176±68 vs. 135±62; p

Keywords

• Percutaneous coronary intervention, platelet to lymphocyte ratio; ST elevation myocardial infarction; stent thrombosis

ST Yükselmeli Miyokard İnfarktüslü Hastalarda Stent Trombozunu Öngörmede Trombosit-Lenfosit Oranının Kullanışlılığı

Abstract

Giriş: İyatrojenik bir hastalık olan stent trombozu, perkutan koroner girişimin (PCI) önemli bir komplikasyonudur. Trombosit lenfosit oranının (PLR) son zamanlarda daha çok kanser hastalarında, tromboz ve inflamasyonun bir belirteci olduğu gösterilmiştir. Bu çalışmanın amacı akut ST yükselmeli miyokard infarktüsü (STYMİ) ile başvuran hastalarda PLR'nin stent trombozu gelişiminin bir öngördürücüsü olup olmadığını araştırmaktır.Hastalar ve Yöntem: Akut ST yükselmeli miyokard infarktüsü tanısıyla primer PCI yapılan ve daha sonra stabil anjina veya Akut koroner sendrom tanısıyla tekrar koroner anjiyografi yapılarak stent trombozu tanısı alan 54 olgu çalışmanın hasta grubunu oluştururken; bunlarla yaş, cinsiyet, koroner risk faktörleri, stent uygulama prosedürü ile stent tipi ve boyu bakımından benzer olup primer PCI sonrası yapılan koroner anjiyografide stenti patent bulunan 147 hasta kontrol grubunu oluşturdu. Toplam 201 hastanın (ortalama yaş 59,8±13,1 yıl, ¾'ü erkek) klinik, hematolojik ve anjiyografik verilerini retrospektif olarak inceledik.Bulgular: İşlem öncesi PLR, stent trombozu gelişen hastalarda gelişmeyenler ile karşılaştıldığında anlamlı olarak daha yüksekti (176±68'e karşı 135±62; p

Keywords

• Perkutan koroner girişim, trombosit lenfosit oranı; ST yükselmeli miyokard infarktüsü; stent trombozu

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