Serum Visfatin Levels and Coronary Artery Disease

Abstract

Introduction: Adipose tissue is not only source of energy but also an active endocrine organ serving function by secreting bioactive molecules called adipokines. Visfatin is a recently discovered adipokine and is proposed to play role in inflammatory and atherosclerotic states. We aimed to investigate the association of visfatin with coronary artery disease (CAD).Patients and Methods: Twenty patients undergoing coronary artery bypass grafting due to CAD were compared with 20 individuals without CAD angiographically. Gender, age, body mass index, and serum visfatin levels were compared between the two groups. Relationship of visfatin levels and severity of CAD, cross-clamp and cardiopulmonary bypass times were also investigated in the study group.Results: Age, gender, BMI, and blood pressures were not significantly different between the groups. There was significant difference in serum visfatin levels between the two groups (47.31±33.03 ng/mL and 9.04±7.18 ng/mL, p=0.0001). A strong correlation between the Gensini score and pre-operative visfatin levels (r=0.81; p=0.0001) was observed for the study group. No correlation was detected between the visfatin level and cardiopulmonary bypass and cross clamp times.Conclusion: Increased visfatin levels may be associated with inflammation and atherosclerotic cardiovascular diseases. Circulating visfatin level is increased in patients undergoing coronary artery bypass grafting. Further studies are warranted to determine the predictive value of serum visfatin as a biomarker and potential therapeutic target for metabolic and cardiovascular diseases.

Keywords

• Adipose tissue, adipokine; visfatin; atherosclerosis; coronary artery disease

Serum Visfatin Seviyesi ve Koroner Arter Hastalığı

Abstract

Giriş: Yağ dokusu yalnızca enerji kaynağı olmayıp aynı zamanda adipokin olarak adlandırılan biyoaktif maddeleri salgılayan bir endokrin organdır. Visfatin son dönemlerde keşfedilen, inflamasyon ve ateroskleroz ile ilişkilendirilen bir adipokindir. Bu çalışmada visfatinin koroner arter hastalığı ile ilişkisini araştırmayı amaçladık.Hastalar ve Yöntem: Koroner arter hastalığı sebebiyle koroner arter baypas greftleme planlanan 20 hasta anjiografik olarak koroner arter hastalığı olmayan 20 bireyle kıyaslandı. Cinsiyet, yaş, vücut kitle indeksi ve serum visfatin seviyesi gruplar arasında karşılaştırıldı. Visfatin seviyesinin koroner arter hastalığının ciddiyeti, aortic kros klemp zamanı ve kardiyopulmoner baypas zamanı ile ilişkisi de incelendi.Bulgular: Gruplar arasında yaş, cinsiyet, vücut kitle indeksi ve kan basınçları arasında fark saptanmadı. Serum visfatin seviyeleriyse anlamlı farklı bulundu (47,31±33,03 ng/ml ve 9,04±7,18 ng/ml, p=0,0001). Gensini skoru ile preoperative visfatin seviyesi arasında güçlü korelasyon saptandı (r=0,81; p=0,0001). Visfatin seviyesi ile kardiyopulmoner baypas ve aortic kros klemp zamanı arasında ilişki saptanmadı.Sonuç: Artmış serum visfatin seviyesi inflamasyon ve aterosklerotik kardiyovasküler hastalıklarla ilişkili olabilir. Dolaşımdaki visfatin seviyesi koroner arter baypas greftleme yapılan hastalarda artmıştır. Serum visfatin seviyesinin koroner arter hastalığı ile ilişkisi ve tedavi hedefleri arasındaki yerini belirleyebilmek için büyük ölçekli çalışmalara ihtiyaç vardır.

Keywords

• Adipoz doku, adipokin; visfatin; ateroskleroz; koroner arter hastalığı

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