Acute Increase in Postoperative White Cell Count Predicts Mortality in Isolated Aortic Valve Replacement Patients

Abstract

Introduction: Inflammatory reaction after cardiac surgery is well documented. In this study we aimed to investigate association with acute increase in white blood cell count after cardiopulmonary bypass with mortality. Patients and Methods: We included 35 patients with isolated aortic valve replacement procedure with cardiopulmonary bypass during time phrase June 2009 to July 2013. Blood sampled the day before the operation and on postoperative 24th hour. White blood cell counted and preoperative postoperative difference was calculated. Results: Total 35 patients were included to study. 14 (40%) of them were female. Mean age of patients was 61.14±13.25. Mortality observed patients had two fold increase in mean white blood cell count (preoperative/postoperative white blood cell count 4.971±1.11/ 8.19±3.47 p=0.03 95% CI 1.88-8.06/3.88-12.50). Conclusion: Acute increase in white cell count after aortic valve replacement procedure is associated with mortality.

Keywords

• Aortic Valve, White Blood Cell Count, Mortality

İzole Aort Kapak Replasmanı Yapılan Hastalarda Postoperatif Beyaz Küre Artışı Mortalite Belirtecidir

Abstract

Giriş: Kalp cerrahisi sonrası inflamatuvar reaksiyon iyi dökümente edilmiştir. Bu çalışmada, kardiyopulmoner bypass sonrası beyaz kan hücrelerinde akut artış ile mortalite arasındaki ilişkiyi incelemeyi amaçladık.Hastalar ve Yöntem: Haziran 2009- Temmuz 2013 arasında kardiyopulmoner bypass eşliğinde izole aort kapak replasmanı uygulanan 35 hasta çalışmaya dahil edildi. Kan örnekleri operasyondan önceki gün ve postoperatif 24. saatte alındı. Beyaz kan hücreleri sayıldı ve operasyon öncesi ve sonrası değerler hesaplandı.Bulgular: Toplam 35 hasta çalışmaya alındı. Ondört tanesi (40%) kadındı. Ortalama yaş 61.14+ 13.25 idi. Mortalite izlenen hastalarda beyaz kan hücresi sayısında iki kat artış olduğu görüldü ( preoperatif-postoperatif beyaz hücre sayıları 4.971+1.11/ 8.19+3.47 p=0.03 95% CI 1.88-8.06/3.88-12.50).Sonuç: Aort kapak replasmanı sonrası beyaz kan hücrelerinin akut artışı mortalite ile ilişkilidir.

Keywords

• Aort kapak, beyaz kan hücre sayısı; mortalite

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