P Wave and QT Dispersion in Patients with Generalized Anxiety Disorder

Abstract

Introduction: The aim of this study is to investigate P wave dispersion (Pd) and QT dispersion (QTd), non-invasive predictors of atrial fi brillation and ventricular arrhythmia or sudden cardiac death, respectively, in patients with generalized anxiety disorder (GAD). Patients and Methods: A total of 40 outpatients diagnosed as GAD and 29 healthy control subjects were included in the study. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) were administered and 12-lead ECG measurements were obtained. Pd and QTd measurements were performed by blinded cardiologists. Results: BAI scores (26.6 ± 11.8 vs. 3.4 ± 3.3, p< 0.001) and BDI scores (12.6 ± 4 vs. 3.7 ± 4.5, p< 0.001) were signifi cantly higher in the patient group compared to the controls. P wave dispersion (Pd) [50.0 ± 17.5 miliseconds (ms) vs. 23.4 ± 7.7 ms, p< 0.001] and mean QT dispersion (QTd) (50.5 ± 18.1 ms vs. 28.3 ± 11.4 ms, p< 0.001) signifi cantly increased in the GAD patient group compared to the controls. Conclusion: Increase in Pd may suggest that GAD patients have increased risk of atrial fi brillation. Similarly, increased QTd may show that these patients have a higher risk of ventricular arrhythmia.

Keywords

• ECG, heart, anxiety disorders.

Yaygın Anksiyete Bozukluğu Olan Hastalarda P ve QT Dispersiyonu

Abstract

Giriş: Çalışmamızın amacı; yaygın anksiyete bozukluğu (YAB) olan hastalarda, ventriküler aritmi ve ani kardiyak ölümün noninvaziv belirleyicisi olan QT dispersiyonu ile atriyal aritminin noninvaziv belirleyicisi olan P dispersiyonunu araştırmaktır. Hastalar ve Metod: Ayaktan 40 YAB olan hasta ve 29 sağlıklı kontrol çalışmaya dahil edildi, Beck Anksiyete Envanteri (BAE) ve Beck Depresyon Envanteri (BDE) uygulandı ve 12 derivasyonlu EKG ölçümleri elde edildi. Pd ve QTd ölçümleri tek kör kardiyolog tarafından yapıldı. Bulgular: BAE puanları (26.6 ± 11.8 vs. 3.4 ± 3.3, p< 0.001) ve BDE puanları (12.6 ± 4 vs 3.7 ± 4.5, p< 0.001) kontrol grubuna göre hasta grubunda anlamlı olarak daha yüksekti. P dispersiyonu (Pd) [50.0 ± 17.5 milisaniye (ms) vs. 23.4 ± 7.7 ms, p< 0.001] ve ortalama QT dispersiyonu (QTd) (50.5 ± 18.1 msn vs. 28.3 ± 11.4 msn, p< 0.001)'nda kontrol grubuna göre hasta grubunda anlamlı olarak daha yüksekti. Sonuç: Pd ve QTd belirgin olarak YAB hastalarında artmıştır. Bu sonuçlar, YAB olan hastalarda artmış Pd'nin atriyal aritmi riskini artırabileceğini, artmış QTd'nin ise ventriküler aritminin artmış riskini düşündürmektedir

Keywords

• EKG, kalp, anksiyete bozukluğu.

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