Cardiac Allograft Vasculopathy and Coronary Artery Disease Development with Orthotopic Heart Transplantation

Abstract

Cardiac allograft vasculopathy is an accelerated form coronary artery disease that characterized by development of fibrous intimal hyperplasia of all coronary artery. This is a major factor determining long-term survival in heart transplantation. Three (4%) patients were developed coronary artery disease and allograft vasculopathy from orthotopik heart transplantation in 62 patients at our clinic in late follow-up. There were two of the male, one female patients and age 22, 24 and 39, respectively. Because of development in young patients multivessel disease were performed invasive procedures. Women patient was died after diagnosed one year. Two patients continued medical follow-up. Allograft vasculopathy is very diffuse pathology that invasive procedures success is limited in the treatment.

Keywords

• Heart transplantation; coronary vessels; graft rejection.

Ortotopik Kalp Transplantasyonlu Hastalarda Kardiyak Allogreft Vaskülopati ve Koroner Arter Hastalığı

Abstract

Kardiyak allogreft vaskülopatisi tüm koroner arter boyunca fibröz intimal hiperplazinin gelişimi ile karakterize koroner arter hastalığının hızlandırılmış bir formudur. Kalp transplantasyonunda uzun dönem sağkalımda belirleyici majör bir faktördür. Kliniğimizde ortotopik kalp transplantasyonu uygulanmış 62 hastanın 3 (%4)'ünde geç dönem takiplerinde koroner arter hastalığı ve allogreft vaskülopati gelişimi görüldü. Hastaların ikisi erkek, biri kadın olup yaşları 22, 24 ve 39 idi. Genç hastalarda multidamar hastalığı gelişmesi nedeniyle invazif işlem uygulandı. Kadın olan hasta tanı konulduktan bir yıl sonra kaybedildi. İki hastanın medikal takipleri devam etmektedir. Allogreft vaskülopatisi oldukça difüz seyreden, tedavisinde invazif işlemlerin başarısının sınırlı olduğu bir patolojidir

Keywords

• Kardiyak allogreft vaskülopatisi tüm koroner arter boyunca fibröz intimal hiperplazinin gelişimiile karakterize koroner arter hastalığının hızlandırılmış bir formudur. Kalp transplantasyonundauzun dönem sağkalımda belirleyici majör bir f

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