EFFECT OF VENTILATION ON PULMONARY EPITHELIAL PERMEABILITY DURING CARDIOPULMONARY BYPASS

Abstract

Ventilation of the lungs during cardiopulmonary bypass may have a protective effect against postoperative lung injury Lung disturbances after cardiopulmonary bypass include pulmonary endothelial, interstitial and epithelial damage that can be demonstrated by Tc-99mlabeled diethylenetriamine pentaacetic acid inhalation scintigraphy. This study was conducted on 22 patients with on-pump coronary bypass operation. The study group n=9) received ventilation: respiratory rate 6 breaths/min, tidal volume 200 ml, and fraction of inspired oxygen 50% during extracorporeal circulation. The control group was not ventilated during CPB. Inhalation scintigraphy was performed to all patients preoperatively and postoperatively within the first week. Preoperative and postoperative median epithelial clearances of the ventilated group were 68.41 and 55.80 minutes, respectively. In the nonventilated group, preoperative and postoperative clearances were 84.20 and 82.29 minutes, respectively. In both groups, there was no significant difference between preoperative and postoperative values. The effect of ventilation may not be detectable via Tc-99m-labeled diethylenetriamine pentaacetic acid inhalation scintigraphy.

Keywords

• Ventilation; Cardiopulmonary bypass; Tc 99m DTPA;Pulmonary epithelial permeability; Pulmonary scintigraphy