Association Between Apolipoprotein-B100 and Apolipoprotein-A1 in Patients with Coronary Slow Flow

Year 2010, Volume: 13 Issue: 2, 11 - 15, 01.02.2009

Ramazan Kargin Yunus Emiroglu Selçuk Pala Mustafa Akcakoyun Soe Moe Aung Özkan Candan Suzan Hatipo¤lu Nihal Özdemir

Abstract

Objective: Although several hypotheses have been suggested, the underlying mechanism of coronary slow flow phenomenon (CSFP) has not been well established yet. The aim of this study was to determine the roles of plasma apolipoprotein-B100 (Apo-B) and apolipoprotein-A1 (Apo-A1) in CSFP which have an atherogenic effect and anti-atherogenic effects respectively. Methods: The study consisted of 31 patients with CSFP (group 1), 28 normal subjects as control group (group 2) and 30 patients with coronary artery disease (CAD) (group 3) detected by coronary angiography. CSFP was diagnosed by the TIMI frame count method. Blood Apo-B, Apo-A1, Apo-B/Apo-A1 ratio, and demographic parameters were compared between the groups. Results: The Apo-B values were 93±25 mg/dL, 90±26 mg/dL, and 106±27 mg/dL in groups 1, 2 and 3, respectively (p=0.048 between group 1 and 3, p=0.041 between group 2 and 3, p= NS between group 1 and 2). The Apo-A1values were 127±14 mg/dL, 125±21 mg/dL and 106±27 mg/dL in groups 1, 2 and 3 respectively (p=0.028 between group 1 and 3, p=0.021 between group 2 and 3, p= NS between group 1 and 2). The apo- B/apo-A1 ratio were 0.73±0.18, 0.69±0.23 and 0.98±0.20 in groups 1, 2 and 3 respectively (p=0.017 between group 1 and 3, p=0.010 between group 2 and 3, p= NS between group 1 and 2). Conclusion: Although lower levels of plasma Apo-A1 and higher levels of Apo-B and the ratio of Apo-B to Apo-A1 are related with CAD, there is no relationship between these apolipoproteins and CSFP.

Keywords

Coronary slow flow phenomenon, Apolipoproteins, Atherogenic and anti-atherogenic effects

Koroner Yavafl Ak›m Hastalar›nda Apolipoprotein-B100 ve Apolipoprotein-A1 Aras›ndaki ‹liflki

Abstract

Amaç: Koroner yavafl ak›m fenomenin (KYAF) altta yatan mekanizmas› henüz tam olarak tan›mlanmam›fl olmas› na ra¤men çeflitli hipotezler ileri sürülmüfltür. Bu çal›flmam›z da s›ras›yla aterojenik ve anti-aterojenik etki gösteren plazma apolipoprotein-B100 (Apo-B) ve apolipoprotein-A1'in (Apo-A1) KYAF'deki rolünü araflt›rd›k. Yöntemler: Çal›flmaya koroner anjiografik olarak KYAF'si olan 31 hasta (grup 1) ile normal kiflilerden oluflan 28 kontrol grubu (grup 2) ve koroner arter hastal›¤› olan 30 hasta (grup 3) al›nd›. KYAF tan›s› TIMI kare say›s› yöntemiyle kondu. Gruplar›n plazma Apo-B, Apo-A1, Apo-B/Apo-A1 oran› ve demografik özellikleri karfl›laflt›r›ld›. Bulgular: Grup 1, 2 ve 3'deki ortalama Apo-B de¤erlerini s›ras›yla 93±25 mg/dL, 90±26 mg/dL, 106±27 mg/dL olarak saptad›k (grup 1 ile 3 aras›ndaki p=0.048, grup 2 ile 3 aras›ndaki p=0.041, grup 1 ile 2 aras›ndaki p= AD). Grup 1, 2 ve 3'deki ortalama Apo-A1 de¤erlerini s›ras›yla 127±14 mg/dL, 125±21 mg/dL, 106±27 mg/dL olarak saptad›k (grup 1 ile 3 aras›ndaki p=0.028, grup 2 ile 3 aras›ndaki p=0.021, grup 1 ile 2 aras›ndaki p= AD). Grup 1, 2 ve 3'deki Apo-B/Apo-A1 oran›n› ise s›ras›yla 0.73±0.18, 0.69±0.23 ve 0.98±0.20 olarak saptad›k (grup1 ile 3 aras›ndaki p=0.017, grup 2 ile 3 aras›ndaki p=0.010, grup 1 ile 2 aras›ndaki p= AD). Sonuç: Koroner arter hastal›¤› düflük plazma Apo-A1 düzeyi ile yüksek plazma Apo-B düzeyi ve Apo-B/Apo- A1 oran› ile iliflkilendirilmifl olmas›na ra¤men apolipoproteinler ile KYAF aras›nda bu iliflki bulunmam›flt›r.

Keywords

Koroner yavafl ak›m fenomeni, Apolipoproteinler, Aterojenik ve anti-aterojenik etki

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