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Year 2022, Volume: 5 Issue: 2, 159 - 166, 30.11.2022
https://doi.org/10.34088/kojose.792056

Abstract

References

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  • [6] Zhao L.-Y., Liu J.-Y., Ouyang W.-W., Li D.-Y., Li L., Li L.-Y., Tang J.-T., 2013. Magnetic-mediated hyperthermia for cancer treatment: Research progress and clinical trials. Chinese Phys. B, 22, 108104.
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  • [8] Dhavalikar R., Rinaldi C., 2016. Theoretical predictions for spatially-focused heating of magnetic nanoparticles guided by magnetic particle imaging field gradients. J. Magn. Magn. Mater., 419, pp. 267–273.
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  • [12] Ma M., Zhang Y., Shen X., Xie J., Li Y., Gu N., 2015. Targeted inductive heating of nanomagnets by a combination of alternating current (AC) and static magnetic fields. Nano Res., 8, pp. 600–610.
  • [13] Bauer L.M., Situ, S.F., Griswold M.A., Samia A.C.S., 2016. High-performance iron oxide nanoparticles for magnetic particle imaging-guided hyperthermia (hMPI). Nanoscale, 8, pp. 12162–12169.
  • [14] Murase K., Takata H., Takeuchi Y., Saito S., 2013. Control of the temperature rise in magnetic hyperthermia with the use of an external static magnetic field. Phys. Medica, 29, pp. 624–630.
  • [15] Zhao Q., Wang L., Cheng R., Mao L., Arnold R.D., Howerth E.W., Chen Z.G., Platt S., 2012. Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models. Theranostics, 2, pp. 113–121.
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  • [17] Ren Z.H., Mu W.C., Huang S.Y., 2019. Design and Optimization of a Ring-Pair Permanent Magnet Array for Head Imaging in a Low-Field Portable MRI System. IEEE Trans. Magn., 55, pp. 1–8.
  • [18] Mahadi W.N.L.W., Adi S.R., Nor K.M., 2003. Application of the rare earth permanent magnet in a linear generator driven by an internal combustion engine. In Proceedings of the National Power Engineering Conference, PECon 2003 – Proceedings, pp. 256–261.
  • [19] Vilas-Boas V., Carvalho F., Espiña B., 2020. Magnetic hyperthermia for cancer treatment: Main parameters affecting the outcome of in vitro and in vivo studies. Molecules, 25.

Mapping of Gradient Patterns Generated with Helmholtz Coils for Localized Magnetic Fluid Hyperthermia

Year 2022, Volume: 5 Issue: 2, 159 - 166, 30.11.2022
https://doi.org/10.34088/kojose.792056

Abstract

Magnetic fluid hyperthermia (MFH) is a new generation cancer treatment method under development. One of the challenges that arise in the practical applications of MFH is the limited control of magnetic nanoparticles (MNP). In order to overcome this problem, new approaches are being investigated in MFH tests. Localization of MNP oscillations can be achieved through static magnetic field-free region (FFR) and static magnetic field (SMF) gradients generated by permanent magnets or electromagnets. In this study, Helmholtz coils were used as SMF source to generate gradient patterns (GPs). Finite element method simulation was used to predict GPs that would emerge in the study area. An experiment platform was produced in which the GP would be generated with parametric current changes. Measurements were taken when source currents were (1.1, 1.1 ), (2.2, 2.2), (4.4, 4.4) and (2.2, -2.2) A, respectively. It was observed that FFR form could be manipulated with coil current. The mapping of the GPs and determining FFRs for the use of localized MFH were discussed for the first time in this study. The findings provide insight into which GP is appropriate in which situations in localized MFH.

References

  • [1] Huang J., Zhong X., Wang L., Yang L., Mao H., 2012. Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticles. Theranostics, 2, pp. 86–102.
  • [2] Estelrich J., Sánchez-Martín M.J., Busquets M.A., 2015. Nanoparticles in magnetic resonance imaging: From simple to dual contrast agents. Int. J. Nanomedicine, 10, pp. 1727–1741.
  • [3] Arruebo M., Fernández-Pacheco R., Ibarra M.R., Santamaría J., 2007. Magnetic nanoparticles for drug delivery. Nano Today, 2, pp. 22–32.
  • [4] Mura S., Nicolas J., Couvreur, P., 2013. Stimuli-responsive nanocarriers for drug delivery. Nat. Mater., 12, pp. 991–1003.
  • [5] Mahmoudi K., Bouras A., Bozec D., Ivkov R., Hadjipanayis C., 2018. Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans. Int. J. Hyperth., 34, pp. 1316–1328.
  • [6] Zhao L.-Y., Liu J.-Y., Ouyang W.-W., Li D.-Y., Li L., Li L.-Y., Tang J.-T., 2013. Magnetic-mediated hyperthermia for cancer treatment: Research progress and clinical trials. Chinese Phys. B, 22, 108104.
  • [7] Deatsch A.E., Evans B.A., 2014. Heating efficiency in magnetic nanoparticle hyperthermia. J. Magn. Magn. Mater., 354, pp. 163–172.
  • [8] Dhavalikar R., Rinaldi C., 2016. Theoretical predictions for spatially-focused heating of magnetic nanoparticles guided by magnetic particle imaging field gradients. J. Magn. Magn. Mater., 419, pp. 267–273.
  • [9] Cantillon-Murphy P., Wald L.L., Zahn M., Adalsteinsson E., 2010. Proposing magnetic nanoparticle hyperthermia in low-field MRI. Concepts Magn. Reson. Part A Bridg. Educ. Res., 36, pp. 36–47.
  • [10] Tasci T.O., Vargel I., Arat A., Guzel E., Korkusuz P., Atalar E., 2009. Focused RF hyperthermia using magnetic fluids. Med. Phys., 36, pp. 1906–1912.
  • [11] Lu Y., Rivera-Rodriguez A., Tay Z.W., Hensley D., Fung K.L.B., Colson C., Saayujya C., Huynh, Q., Kabuli L., Fellows B., 2020. Combining magnetic particle imaging and magnetic fluid hyperthermia for localized and image-guided treatment. Int. J. Hyperth., 37, pp. 141–154.
  • [12] Ma M., Zhang Y., Shen X., Xie J., Li Y., Gu N., 2015. Targeted inductive heating of nanomagnets by a combination of alternating current (AC) and static magnetic fields. Nano Res., 8, pp. 600–610.
  • [13] Bauer L.M., Situ, S.F., Griswold M.A., Samia A.C.S., 2016. High-performance iron oxide nanoparticles for magnetic particle imaging-guided hyperthermia (hMPI). Nanoscale, 8, pp. 12162–12169.
  • [14] Murase K., Takata H., Takeuchi Y., Saito S., 2013. Control of the temperature rise in magnetic hyperthermia with the use of an external static magnetic field. Phys. Medica, 29, pp. 624–630.
  • [15] Zhao Q., Wang L., Cheng R., Mao L., Arnold R.D., Howerth E.W., Chen Z.G., Platt S., 2012. Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models. Theranostics, 2, pp. 113–121.
  • [16] Ristic-Djurovic J.L., Gajic S.S., Ilic A.Z., Romcevic N., Djordjevich D.M., De Luka S.R., Trbovich A.M., Jokic V.S., Cirkovic S., 2018. Design and Optimization of Electromagnets for Biomedical Experiments With Static Magnetic and ELF Electromagnetic Fields. IEEE Trans. Ind. Electron., 65, pp. 4991–5000.
  • [17] Ren Z.H., Mu W.C., Huang S.Y., 2019. Design and Optimization of a Ring-Pair Permanent Magnet Array for Head Imaging in a Low-Field Portable MRI System. IEEE Trans. Magn., 55, pp. 1–8.
  • [18] Mahadi W.N.L.W., Adi S.R., Nor K.M., 2003. Application of the rare earth permanent magnet in a linear generator driven by an internal combustion engine. In Proceedings of the National Power Engineering Conference, PECon 2003 – Proceedings, pp. 256–261.
  • [19] Vilas-Boas V., Carvalho F., Espiña B., 2020. Magnetic hyperthermia for cancer treatment: Main parameters affecting the outcome of in vitro and in vivo studies. Molecules, 25.
There are 19 citations in total.

Details

Primary Language English
Subjects Metrology, Applied and Industrial Physics, Biomedical Engineering, Electrical Engineering
Journal Section Articles
Authors

Serhat Küçükdermenci 0000-0002-6421-7773

Early Pub Date October 17, 2022
Publication Date November 30, 2022
Acceptance Date April 22, 2022
Published in Issue Year 2022 Volume: 5 Issue: 2

Cite

APA Küçükdermenci, S. (2022). Mapping of Gradient Patterns Generated with Helmholtz Coils for Localized Magnetic Fluid Hyperthermia. Kocaeli Journal of Science and Engineering, 5(2), 159-166. https://doi.org/10.34088/kojose.792056