İlaç Ko-Kristallerinin Fiziksel Özelliklerinin Çözünme Konsantrasyonuna Etkisinin Analizi

Year 2021, Volume: 9 , 213 - 223, 30.12.2021

Sinem Elmas , Fatma Elif Genceli Güner

https://doi.org/10.36306/konjes.998111

Abstract

Sedef hastalığı bulaşıcı olmayan bir deri hastalığıdır. Hastalığın tedavi yöntemi şiddetine göre değişmektedir. Şiddetli evrelerde ağız yolu ile yapılan tedavilerde, çözünme davranışı, ko-kristali değerlendirmek, çözünme mekanizmasını anlamak ve ilacın biyoyararlanımını tahmin etmek için önemli bir karakterizasyon aşamasıdır. Bu çalışmada sedef hastalığının ağız yoluyla tedavisinde kullanılan ko-kristallerin (i) farklı şekil, (ii) boyutlarının ve (iii) öğütme işleminin çözünme davranışı üzerindeki etkisi ultraviyole-görünür (UV/Vis) spektroskopisi ile analiz edilmiştir. Çözünme konsantrasyonunun değişen fiziksel özellikler ve öğütme işlemi ile birlikte arttığı kanıtlanmıştır.

Keywords

Kokristal, Çözünme konsantrasyonu, Öğütme, UV/Vis spektroskopisi

ANALYSIS OF THE EFFECT OF PHYSICAL PROPERTIES OF DRUG CO-CRYSTALS ON DISSOLUTION CONCENTRATION

Abstract

Psoriasis is an itchy and non-contagious skin disease. Its treatment method varies according to the severity of the disease. In oral treatments used in heavy stages, dissolution behavior is a vital characterization parameter for evaluating cocrystal, understanding dissolution mechanism, and predicting bioavailability of the drug. In this study, dissolution of cocrystals used in psoriasis was investigated. Effect of (i) different shapes, (ii) sizes, and (iii) grinding of cocrystals on the dissolution were considered with ultraviolet-visible (UV/Vis) spectroscopy. Results show that different physical properties and grinding can significantly increase the dissolution of cocrystals.

Keywords

Cocrystal, Dissolution concentration, Grinding, UV/Vis spectroscopy

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