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BEHÇET HASTALARINDA DEPRESYON ANKSİYETE BELİRTİLERİ SIKLIĞI VE BEHÇET HASTALIĞI AKTİVİTESİ İLE İLİŞKİSİ

Year 2018, Volume: 26 Issue: 2, 0 - 0, 28.08.2018

Abstract

Giriş: Behçet hastalığı oral aftöz lezyonlar, genital ülserler, deri lezyonları, göz, eklem, damar, merkezi sinir sistemi ve gastrointestinal sistem tutulumları ile seyreden sistemik bir vaskülittir. Behçet hastalığında depresyon ve anksiyete bozukluğu gibi ruhsal hastalıkların sık görüldüğü bildirilmektedir. Hastalık aktivitesi ile ruhsal hastalıklar arasındaki ilişkiyi ortaya koyan çalışma sayısı yetersizdir. Çalışmamızda Behçet hastalarında depresyon, anksiyete bozukluğu belirtilerinin düzeyinin belirlenmesi ve bu belirtilerin Behçet hastalığının aktivitesi ile ilişkisinin ortaya konması amaçlanmıştır. Yöntem: Örneklem Ankara Üniversitesi Tıp Fakültesi’ne Ocak– Mart 2017 tarihleri arasında başvuran Behçet hastalarından (n=92) oluşturulmuştur. Çalışma kesitsel nitelikte olup katılımcılara sosyodemografik bilgi formu, Behçet Hastalığı Aktivite Formu, Hastane Anksiyete Depresyon Ölçeği (HAD) ve Genel Sağlık Anketi (GSA) uygulanmıştır. Frekans analizleri, Pearson ve Spearman Rank korelasyon analizleri uygulanmıştır. Bulgular: Katılımcıların %64.7’si (n=62) kadın ve ortalama hastalık yılı 12.48 ± (9.98) yıldır. Katılımcıların %37.0’ı (n=34) HAD’den eşik üstü puan almıştır. Katılımcıların %54.3’ü (n=50) GSA’dan eşik üstü puan almıştır. HAD toplam puanları ve GSA puanları ile hastalık aktivitesi arasında pozitif bir korelasyon olduğu saptanmıştır (sırasıyla p<0.0001 p=0.017). Tartışma: Çalışmamızda elde edilen bulgular ışığında Behçet hastalığı olan bireylerde depresyon ve anksiyete belirtilerinin normal popülasyondan daha fazla olduğu gözlenmiştir. Hastalık aktivitesi ile bireylerdeki depresyon-anksiyete belirtileri arasında ilişki vardır. Bulgularımız literatür ile uyumludur. Bu bulgular doğrultusunda Behçet hastalığı konan bireylerde ruhsal belirtilerin normal popülasyondan daha fazla olduğu akılda tutulmalı ve psikiyatrik konsültasyonun tedavi protokolünün bir parçası haline getirilmesi önerilmektedir.

References

  • Alevizos, B., Anagnostara, C., & Christodoulou, G. N. (2004). Resistant bipolar disorder precipitated by Behçet's syndrome. Bipolar disorders, 6(3), 260-263.
  • Al-Fahad, S. A., & Al-Araji, A. H. (1999). Neuro-Behcet’s disease in Iraq: a study of 40 patients. Journal of the neurological sciences, 170(2), 105-111.1)
  • Akdeniz, N., Esrefoglu, M., Keles, M. S., Karakuzu, A., & Atasoy, M. (2004). Serum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behcet's disease. ANNALS-ACADEMY OF MEDICINE SINGAPORE, 33(5), 596-599.
  • Aydemir, Ö., Güvenir, T., Küey, L., & Kültür, S. (1997). Hastane anksiyete ve depresyon ölçeği Türkçe formunun geçerlilik ve güvenilirliği. Türk Psikiyatri Dergisi, 8(4), 280-7.
  • Bagheri, F., Mani, A., Tadayyoni, A., Firozi, F., & Nazarinia, M. A. (2013). The prevalence of psychiatric symptoms in the patients with Behcet's disease in Shiraz, Southwest of Iran. Journal of Mood Disorders, 3(1), 28.
  • Bernabé, E., Marcenes, W., Mather, J., Phillips, C., & Fortune, F. (2010). Impact of Behçet’s syndrome on health-related quality of life: influence of the type and number of symptoms. Rheumatology, 49(11), 2165-2171.
  • Bhakta, B. B., Brennan, P., James, T. E., Chamberlain, M. A., Noble, B. A., & Silman, A. J. (1999). Behcet's disease: evaluation of a new instrument to measure clinical activity. Rheumatology, 38(8), 728-733.
  • Blackford, S., Finlay, A. Y., & Roberts, D. L. (1997). Quality of lite in Beheet's syndrome: 335 patients surveyed. British Journal of Dermatology, 136(2), 293-293.
  • Bodur, H., Borman, P., Özdemir, Y., Atan, Ç., & Kural, G. (2006). Quality of life and life satisfaction in patients with Behçet's disease: relationship with disease activity. Clinical rheumatology, 25(3), 329-333.
  • Brebner, K., Hayley, S., Zacharko, R., Merali, Z., & Anisman, H. (2000). Synergistic effects of interleukin-1β, interleukin-6, and tumor necrosis factor-α: central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology, 22(6), 566.
  • Brown, E. S., Khan, D. A., & Nejtek, V. A. (1999). The psychiatric side effects of corticosteroids. Annals of Allergy, Asthma & Immunology, 83(6), 495-504.
  • Canpolat, Ö., & Yurtsever, S. (2011). The quality of life in patients with Behçet’s disease. Asian nursing research, 5(4), 229-235.
  • Chiba, S., Takahashi, S., & Miyagishi, T. (1986). Psychiatric manifestation as an early symptom of Behçet's disease. The British Journal of Psychiatry, 148(6), 752-753.
  • Deniz, O., Çayköylü, A., Vural, G., Albayrak, Y., Temel, Ş., Aydın, İ., & Kuloğlu, M. (2009). A case study of neuro-psycho-Behçet's syndrome presenting with psychotic attack. Clinical neurology and neurosurgery, 111(10), 877-879.
  • Domingos, J., Ferrão, C., Ramalho, J., Rodrigues, T., Moreira, B., Santos, E., ... & Vasconcelos, C. (2015). Characteristics of Neuro-Behçet's Disease in a Case-Series from a Single Centre in Northern Portugal. European neurology, 73(5-6), 321-328.
  • Dursun, R., Uguz, F., Kaya, N., Savas Cilli, A., & Endogru, H. (2007). Psychiatric disorders in patients with Behcet's disease. International journal of psychiatry in clinical practice, 11(1), 16-20.
  • Düzgün, N., Ayaşlioğlu, E., Tutkak, H., & Aydintuğ, O. T. (2005). Cytokine inhibitors: soluble tumor necrosis factor receptor 1 and interleukin-1 receptor antagonist in Behçet’s disease. Rheumatology international, 25(1), 1-5.
  • Dworkin, S. F., Von Korff, M., & LeResche, L. (1990). Multiple pains and psychiatric disturbance: an epidemiologic investigation. Archives of general psychiatry, 47(3), 239-244.
  • Epstein, R. S., Cummings, N. A., Sherwood, E. B., & Bergsma, D. R. (1970). Psychiatric aspects of Behçet's syndrome. Journal of psychosomatic research, 14(2), 161-172.
  • Erberk,Ö. N., Birol, A., Boratav, C., & Kocak, M. (2006). Executive dysfunctions and depression in Behçet’s disease without explicit neurological involvement. Psychiatry and clinical neurosciences, 60(4), 465-472.
  • Ertam, I., Kitapcioglu, G., Aksu, K., Keser, G., Ozaksar, A., Elbi, H., ... & Alper, S. (2009). Quality of life and its relation with disease severity in Behcet's disease. Clinical & Experimental Rheumatology, 27(2), S18.
  • Farah, S., Al-Shubaili, A., Montaser, A., Hussein, J. M., Malaviya, A. N., Mukhtar, M., ... & Trontelj, J. V. (1998). Behçet’s syndrome: a report of 41 patients with emphasis on neurological manifestations. Journal of Neurology, Neurosurgery & Psychiatry, 64(3), 382-384.
  • Gilworth, G., Chamberlain, M. A., Bhakta, B., Haskard, D., Silman, A., & Tennant, A. (2004). Development of the BD-QoL: a quality of life measure specific to Behcet's disease. The Journal of Rheumatology, 31(5), 931-937.
  • Goldberg, D. P. (1972). The detection of psyshiatric illness by questionnaire. Maudsley monograph, 21.
  • Goldberg, D. (2010). The detection and treatment of depression in the physically ill. World Psychiatry, 9(1), 16-20.
  • Hamuryudan, V., Fresko, I., Direskeneli, H., Tenant, M. J., Yurdakul, S., Akoglu, T., & Yazıcı, H. (1999). Evaluation of the Turkish translation of a disease activity form for Behçet's syndrome. Rheumatology, 38(8), 734-736.
  • Hatemi, G., Seyahi, E., Fresko, I., & Hamuryudan, V. (2013). Behçet's syndrome: a critical digest of the 2012-2013 literature. Clinical and experimental rheumatology, 31(3 Suppl 77), 108-117.

FREQUENCY OF DEPRESSION AND ANXIETY SYMPTOMS AND RELATIONSHIP BETWEEN THESE SYMPTOMS AND DISEASE ACTIVITY IN BEHCET DISEASE

Year 2018, Volume: 26 Issue: 2, 0 - 0, 28.08.2018

Abstract

Introduction: Behcet disease is a systemic vasculitis that characterised with oral aftous lesions, genital ulcers, skin lesions, eye, junction, vessel, central nervous system and gastrointestinale system manifestations. It has been reported that mental illness like depression and generalized anxiety disorder are very common in patients with Behcet disease. Researches about relationship between disease activity and mental illness are not enough currently. In our paper we aimed to detect frequency of anxiety and depresive disorder symptoms; and to reveal relationship between these symptoms and activity of behcet disease. Methods: Study sample gathered from the patients with Behcet disease who had applied to Ankara University Faculty of Medicine between January-March 2017. In this cross-sectional study sociodemographic data form, Behcet Disease Current Activity Form(BDCAF), Hospital Anxiety and Depression Scale(HADS), General Health Questionnaire (GHQ) were given to the patients. Results: 64.7% (n=62) of participants were female and mean year of disease was 12.48 ± (9.98) years. 37.0% (n=34) of

sample had scores over the threshold of HADS and of 54.3% (n=50) had scores over the threshold of GHQ. There were positive correlations between HAD and BDCAF; GHQ and BDCAF(subsequently p<0.0001 and p=0.017). Discussion: In the light of our study the patients with Behcet disase display depression and anxiety symptoms more than healty population. There is a relationship between the disease activity and depression-anxiety symptoms. Our findings support current literature about this subject. It must be have a place in our mind that the patients with Behcet Disease display depression and anxiety symptoms more than healty population and psychiatric consultation should be part of the treatment protocol of Behcet disease.

References

  • Alevizos, B., Anagnostara, C., & Christodoulou, G. N. (2004). Resistant bipolar disorder precipitated by Behçet's syndrome. Bipolar disorders, 6(3), 260-263.
  • Al-Fahad, S. A., & Al-Araji, A. H. (1999). Neuro-Behcet’s disease in Iraq: a study of 40 patients. Journal of the neurological sciences, 170(2), 105-111.1)
  • Akdeniz, N., Esrefoglu, M., Keles, M. S., Karakuzu, A., & Atasoy, M. (2004). Serum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behcet's disease. ANNALS-ACADEMY OF MEDICINE SINGAPORE, 33(5), 596-599.
  • Aydemir, Ö., Güvenir, T., Küey, L., & Kültür, S. (1997). Hastane anksiyete ve depresyon ölçeği Türkçe formunun geçerlilik ve güvenilirliği. Türk Psikiyatri Dergisi, 8(4), 280-7.
  • Bagheri, F., Mani, A., Tadayyoni, A., Firozi, F., & Nazarinia, M. A. (2013). The prevalence of psychiatric symptoms in the patients with Behcet's disease in Shiraz, Southwest of Iran. Journal of Mood Disorders, 3(1), 28.
  • Bernabé, E., Marcenes, W., Mather, J., Phillips, C., & Fortune, F. (2010). Impact of Behçet’s syndrome on health-related quality of life: influence of the type and number of symptoms. Rheumatology, 49(11), 2165-2171.
  • Bhakta, B. B., Brennan, P., James, T. E., Chamberlain, M. A., Noble, B. A., & Silman, A. J. (1999). Behcet's disease: evaluation of a new instrument to measure clinical activity. Rheumatology, 38(8), 728-733.
  • Blackford, S., Finlay, A. Y., & Roberts, D. L. (1997). Quality of lite in Beheet's syndrome: 335 patients surveyed. British Journal of Dermatology, 136(2), 293-293.
  • Bodur, H., Borman, P., Özdemir, Y., Atan, Ç., & Kural, G. (2006). Quality of life and life satisfaction in patients with Behçet's disease: relationship with disease activity. Clinical rheumatology, 25(3), 329-333.
  • Brebner, K., Hayley, S., Zacharko, R., Merali, Z., & Anisman, H. (2000). Synergistic effects of interleukin-1β, interleukin-6, and tumor necrosis factor-α: central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology, 22(6), 566.
  • Brown, E. S., Khan, D. A., & Nejtek, V. A. (1999). The psychiatric side effects of corticosteroids. Annals of Allergy, Asthma & Immunology, 83(6), 495-504.
  • Canpolat, Ö., & Yurtsever, S. (2011). The quality of life in patients with Behçet’s disease. Asian nursing research, 5(4), 229-235.
  • Chiba, S., Takahashi, S., & Miyagishi, T. (1986). Psychiatric manifestation as an early symptom of Behçet's disease. The British Journal of Psychiatry, 148(6), 752-753.
  • Deniz, O., Çayköylü, A., Vural, G., Albayrak, Y., Temel, Ş., Aydın, İ., & Kuloğlu, M. (2009). A case study of neuro-psycho-Behçet's syndrome presenting with psychotic attack. Clinical neurology and neurosurgery, 111(10), 877-879.
  • Domingos, J., Ferrão, C., Ramalho, J., Rodrigues, T., Moreira, B., Santos, E., ... & Vasconcelos, C. (2015). Characteristics of Neuro-Behçet's Disease in a Case-Series from a Single Centre in Northern Portugal. European neurology, 73(5-6), 321-328.
  • Dursun, R., Uguz, F., Kaya, N., Savas Cilli, A., & Endogru, H. (2007). Psychiatric disorders in patients with Behcet's disease. International journal of psychiatry in clinical practice, 11(1), 16-20.
  • Düzgün, N., Ayaşlioğlu, E., Tutkak, H., & Aydintuğ, O. T. (2005). Cytokine inhibitors: soluble tumor necrosis factor receptor 1 and interleukin-1 receptor antagonist in Behçet’s disease. Rheumatology international, 25(1), 1-5.
  • Dworkin, S. F., Von Korff, M., & LeResche, L. (1990). Multiple pains and psychiatric disturbance: an epidemiologic investigation. Archives of general psychiatry, 47(3), 239-244.
  • Epstein, R. S., Cummings, N. A., Sherwood, E. B., & Bergsma, D. R. (1970). Psychiatric aspects of Behçet's syndrome. Journal of psychosomatic research, 14(2), 161-172.
  • Erberk,Ö. N., Birol, A., Boratav, C., & Kocak, M. (2006). Executive dysfunctions and depression in Behçet’s disease without explicit neurological involvement. Psychiatry and clinical neurosciences, 60(4), 465-472.
  • Ertam, I., Kitapcioglu, G., Aksu, K., Keser, G., Ozaksar, A., Elbi, H., ... & Alper, S. (2009). Quality of life and its relation with disease severity in Behcet's disease. Clinical & Experimental Rheumatology, 27(2), S18.
  • Farah, S., Al-Shubaili, A., Montaser, A., Hussein, J. M., Malaviya, A. N., Mukhtar, M., ... & Trontelj, J. V. (1998). Behçet’s syndrome: a report of 41 patients with emphasis on neurological manifestations. Journal of Neurology, Neurosurgery & Psychiatry, 64(3), 382-384.
  • Gilworth, G., Chamberlain, M. A., Bhakta, B., Haskard, D., Silman, A., & Tennant, A. (2004). Development of the BD-QoL: a quality of life measure specific to Behcet's disease. The Journal of Rheumatology, 31(5), 931-937.
  • Goldberg, D. P. (1972). The detection of psyshiatric illness by questionnaire. Maudsley monograph, 21.
  • Goldberg, D. (2010). The detection and treatment of depression in the physically ill. World Psychiatry, 9(1), 16-20.
  • Hamuryudan, V., Fresko, I., Direskeneli, H., Tenant, M. J., Yurdakul, S., Akoglu, T., & Yazıcı, H. (1999). Evaluation of the Turkish translation of a disease activity form for Behçet's syndrome. Rheumatology, 38(8), 734-736.
  • Hatemi, G., Seyahi, E., Fresko, I., & Hamuryudan, V. (2013). Behçet's syndrome: a critical digest of the 2012-2013 literature. Clinical and experimental rheumatology, 31(3 Suppl 77), 108-117.
There are 27 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section Research Article
Authors

Oğuzhan Herdi

Beyzanur Şahin Şahin This is me

Berkay Barı This is me

Ayşe Boyvat This is me

Vesile Şentürk Cankorur Şentürk Cankorur This is me

Publication Date August 28, 2018
Submission Date August 1, 2018
Published in Issue Year 2018 Volume: 26 Issue: 2

Cite

APA Herdi, O., Şahin, B. Ş., Barı, B., Boyvat, A., et al. (2018). BEHÇET HASTALARINDA DEPRESYON ANKSİYETE BELİRTİLERİ SIKLIĞI VE BEHÇET HASTALIĞI AKTİVİTESİ İLE İLİŞKİSİ. Kriz Dergisi, 26(2).