The Position and Importance of Sarcopenia in Alzheimer Dementia Patients

Abstract

Abstract

Dementia is an insidious disease that has progressed slowly over the years. There are44.4 million patients diagnosed with dementia all over the world. 7.7 million patientsare added to this number each year. This number is expected to rise to 75.6 million in2030 and to 135.5 million in 2050 (WHO, 2013). Alzheimer's disease has become oneof the most important problems of neurology because of increasing in elderly population and Alzheimer's Disease (AD) is responsible for 60-70% of dementia cases.Sarcopenia is a syndrome that can lead to negative consequences such as physicaldependence, poor quality of life and mortality characterized by loss of progressive muscle strength. Although it has seen at an earlier age depending on the conditions such aschronic diseases, sedentary life and malnutrition, it has seen as 30% over 65 years oldand 50% over 80 years old due to aging. It is important to be aware of the disease anddetect it early.In this article, research on sarcopenia in patients with AD has been compiled and tried to assess the position and importance of sarcopenia in AD.

Keywords

• Alzheimer Disease,demantia,sarcopenia

Alzheimer Tipi Demans Tanılı Hastalarda Sarkopeninin Yeri ve Önemi

Öz

Öz

Demans, sinsi başlangıçlı, yıllar içinde yavaş ve ilerleyici seyirli bir hastalıktır. Tümdünyada 44,4 milyon demanslı hasta vardır. Bu sayıya her yıl 7,7 milyon hasta daha eklenmektedir. Bu sayının 2030 yılında 75,6 milyona, 2050 yılında ise 135,5 milyona çıkması beklenmektedir (DSÖ, 2013). Yaşlı nüfusunun giderek artması, demansın sık karşılaşılan bir durum olması ve demanslı olguların %60-70’inden Alzheimer Hastalığı’nın(AH) sorumlu olması nedeni ile AH, nörolojinin en önemli sorunlarından biri haline gelmiştir.Sarkopeni, ilerleyici kas gücü ve kuvvetinin kaybı ile karakterize olan fiziksel bağım-lılık, kötü yaşam kalitesi ve mortalite gibi olumsuz sonuçlara neden olabilen bir sendromdur. Kronik hastalıklar, sedanter yaşam, malnutrisyon gibi durumlara bağlı daha erkenyaşlarda görülebilse de yaşlanmaya bağlı 65 yaş ve üzerinde %30, 80 yaş üzerinde %50sıklıkla görülür. Hastalığın farkında olunması, erken dönemde saptanması önem arz etmektedir.Bu yazıda, AH tanılı hastalarda sarkopeni ile ilgili araştırmalar derlenmiş ve AH’dayeri ve önemi değerlendirilmeye çalışılmıştır.

Anahtar Kelimeler

• Alzheimer Hastalığı,demans,sarkopeni

References

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