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Erişkinlerde Pnömokok Bağışıklaması

Year 2016, Volume: 8 Issue: 5, 51 - 54, 30.09.2016

Abstract

Pnomokoklar primer olarak insan da hastalık yaparlar. Kaynak genellikle asemptomatik

taşıyıcıların nazofarenksleridir. Pnömokokların yaptığı klinik tablolar üst solunum

yolu enfeksiyonlarından pnömoni, bakteriyemi ve menenjite kadar değişkenlik gösterir.

Toplumdan edinilmiş pnömoniler de en sık bakteriyal etken pnömokoklardır. Pnömoni

ve invazif pnömokokal hastalık tüm dünyada özellikle beş yaş altı çocuklar, 65 yaş

üstü erişkinler ve risk grubunda tanımlanan kişiler de önemli bir mortalite ve morbidite

nedenidir. Surveyans verilerinin ortaya koyduğu antibiyotik direnci özellikle penisilin

grubu antibiyotiklere karşı %50 ye varan direnç artışı göz önüne alındığında koruyuculuk

önem kazanmaktadır. Bağışıklama en etkin koruyucu araçtır ve bugün erişkinlerde

kullanımı onaylanmış olmak üzere iki tip aşı vardır: konjüge pnömokok aşısı

ve polisakkarid pnömokok aşısı. Bu derlemede erişkin popülasyonunda güncel pnömokok

bağışıklama önerileri irdelenmeye çalışılmıştır.

References

  • 1. Erişkin Bağışıklama Rehberi Çalışma Grubu. Erişkin Bağışıklama Rehberi. Ed. Türkiye Enfeksiyon Hastalıkları ve Klinik mikrobiyoloji Derneği. Gümat matbaacılık, İstanbul Mayıs 2016: s.28- 30. 2. Centers For Disease control and Prevention (CDC). Pneumococcal Vaccination: Information for Health Care Providers. http://www.cdc.gov/vaccines/vpd-vac/pneumo/hcp/index.html 19.09.2016 tarihinde erişildi. 3. Hacımustafaoğlu M. Pnömokok Aşıları. Aşı Kitabı. Editörler Badur S, Bakır M. 1. Baskı. 2012 Akademi Uluslarası Yayıncılık sanayi ve tic. Ltd Şti.; İstanbul. s:253-270. 4. Centers For Disease control and Prevention (CDC). PneumococcalDisease. http://www.cdc.gov/vaccines/pubs/pinkbook/pneumo. html 19.09.2016 tarihinde erişildi. 5. Johnson HL, Deloria-Knoll M, Levine OS, Stoszek SK, Freimanis Hance L, Reithinger R, et al. Systematic evaluation of serotypes causing invasive pneumococcaldisease among children under five: the pneumococcal global serotype project. PLoS Medicine, 2010, 7: pii: e1000348. 6. Ulusal Antimikrobiyal Direnç Surveyans Sistemi, 2013 Yılı Yıllık Raporu, Türkiye Halk Sağlığı Kurumu, Sağlık Bakanlığı Ankara, http://uamdss.thsk.gov.tr 19.09.2016 tarihinde erişildi. 7. Lim WS, Macfarlane JT, Boswell TC, Harrison TG, Rose D, Leinonen M et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: Implications for management guidelines. Thorax. 2001;56:296–301. doi: 10.1136/thorax. 56.4.296. 8. Woodhead M. Community-acquired pneumonia in Europe: Causative pathogens and resistance patterns.Eur. Respir. J. Suppl. 2002;36:20s–27s. doi: 10.1183/09031936.02.00702002. 9. T.C. Sağlık Bakanlığı Refik Saydam Hıfzıssıhha Merkezi Başkanlığı Hıfzıssıhha Mektebi Müdürlüğü, Başkent Üniversitesi . Ulusal hastalık yükü ve maliyet-etkililik projesi. Aralık 2004. Hastalık yükü final rapor . Aralık 2004. s:43 http://ekutuphane.tusak.gov.tr/kitaplar/turkiye_hastalik_yuku_calismasi. pdf 24.09.2016 tarihinde ulaşıldı 10 Talbot TR, Poehling KA, Hartert TV, Arbogast PG, Halasa NB, Edwards KM, et al. Seasonality of invasive pneumococcal disease: temporal relation to documentedinfluenza and respiratory syncytial viral circulation. American Journal of Medicine, 2005, 118:285-291. 11. Guillamet CV, Vazquez R, Noe J, Micek ST, Kollef MH.A cohort study of bacteremic pneumonia: The importance of antibiotic resistance and appropriate initial therapy? Medicine (Baltimore). 2016 Aug;95(35):e4708. doi: 10.1097/MD.0000000000004708. 12. World Health Organisation. Pneumococcal vaccines WHO positionpaper- 2012. http://www.who.int/wer/2012/wer8714.pdf?ua=1 20.09.2016 da erişildi 13. Schiffner-Rohe J, Witt A, Hemmerling J, von Eiff C, Leverkus FW. Efficacy of PPV23 in Preventing Pneumococcal Pneumonia in Adults at Increased Risk--A Systematic Reviewand Meta-Analysis. PLoS One. 2016 Jan 13;11(1):e0146338. doi: 10.1371/journal. pone.0146338. eCollection 2016. 14. Pichichero ME. Protein carriers of conjugate vaccines. Characteristics, development, and clinical trials Hum Vaccin Im munother. 2013 Dec 1; 9(12): 2505–2523.doi: 10.4161/hv.26109 15. Grijalva CG, Nuorti JP, Arbogast PG, Martin SW, Edwards KM, Griffin MR. Decline in pneumonia admissions after routine childhood immunization with pnemococcal conjugate vaccine in USA: a time series analysis. Lancet 2007;369:1179 16. Fireman B, Black SB, Shinefield Hr, Lee J, Lewis E, Ray P. Impact of pneumococcal conjugate vaccine on otitis media. Pediatr Infec Dis J 2003, 22:10 17. Madhi SA, Klugman KP, Vaccine Trialist group. A role for streptococcus pneumonia in virüs associated pnemonia. Nat Med 2004;10:811 18. de Roux A, Schmöle-Thoma B, Siber GR, Hackell JG, Kuhnke A, Ahlers N, et al. Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults: conjugate vaccine elicits improved antibacterial immune responses and immunological memory. Clin Infect Dis 2008;46:1015–23 19. Jackson LA, Gurtman A, van Cleeff M, Jansen KU, Jayawardene D, Devlin C,et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults. Vaccine 2013;31:3577-3584 20. Bonten M.J., Huijts S.M., Bolkenbaas M., Webber C., Patterson S., Gault S., et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N. Engl. J. Med. 2015;372:1114–1125. doi: 10.1056/NEJMoa1408544. CAPITA 21. Jackson LA, Gurtman A, Rice K, Pauksens K, Greenberg RN, Jones TR, et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 70 years of age and older previously vaccinated with 23-valent pneumococcal polysaccharide vaccine. Vaccine 2013;31:3585-3593 22. Greenberg RN, Gurtman A, Frenck RW, Strout C, Jansen KU, Trammel J et al. Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naïve adults 60–64 years of age. Vaccine 2014;32:2364–74. 23. Jackson LA, Gurtman A, van Cleeff M, Frenck RW, Treanor J, Jansen KU et al. Influence of initial vaccination with 13-valent pneumococcal conjugate vaccine or 23-valent pneumococcal polysaccharide vaccine on anti-pneumococcal responses following subsequent pneumococcal vaccination in adults 50 years and older. Vaccine 2013;31:3594–602 24. Ishiguro T, Kagiyama N, Uozumi R, Odashima K, Kurashima K, Morita S, et al. Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status. J Infect Chemother. 2016 Oct;22(10):685-91. doi: 10.1016/j.jiac.2016.07.008. 25. Schiffner-Rohe J, Witt A, Hemmerling J, von Eiff C, Leverkus FW. Efficacy of PPV23 in Preventing Pneumococcal Pneumonia in Adults at Increased Risk--A Systematic Reviewand Meta-Analysis. PLoS One. 2016 Jan 13;11(1):e0146338. doi: 10.1371/journal. pone.0146338. eCollection 2016. 26. La Torre G, Mannocci A, Colamesta V, D'Egidio V, Sestili C, Spadea A. Influenza and Pneumococcal Vaccination in Hematological Malignancies: a Systematic Review of Efficacy, Effectiveness, and Safety. Mediterr J Hematol Infect Dis. 2016 Sep 1;8(1):e2016044. doi: 10.4084/MJHID.2016.044. eCollection 2016. 27. Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.Asplenic patients and invasive pneumococcal disease-how bad is it these days? Int J Infect Dis. 2016 Aug 30;51:27-30. doi: 10.1016/j.ijid.2016.08.022. [Epub ahead of print] 28. Tomczyk S, Bennett NM, Stoecker C, Gierke R, Moore MR, Whitney CG, et al. Use of PCV-13 and PPSV-23 vaccine among adults aged 65 and older: recommendations of the ACIP(http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6337a4.ht m). MMWR. 2014;63(37);822-5. 29. Kobayashi M, Bennett NM, Gierke R, Almendares O, Moore MR, MD, Whitney CG et al. Intervals between PCV13 and PPSV23 vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2015;64:944–7.
Year 2016, Volume: 8 Issue: 5, 51 - 54, 30.09.2016

Abstract

References

  • 1. Erişkin Bağışıklama Rehberi Çalışma Grubu. Erişkin Bağışıklama Rehberi. Ed. Türkiye Enfeksiyon Hastalıkları ve Klinik mikrobiyoloji Derneği. Gümat matbaacılık, İstanbul Mayıs 2016: s.28- 30. 2. Centers For Disease control and Prevention (CDC). Pneumococcal Vaccination: Information for Health Care Providers. http://www.cdc.gov/vaccines/vpd-vac/pneumo/hcp/index.html 19.09.2016 tarihinde erişildi. 3. Hacımustafaoğlu M. Pnömokok Aşıları. Aşı Kitabı. Editörler Badur S, Bakır M. 1. Baskı. 2012 Akademi Uluslarası Yayıncılık sanayi ve tic. Ltd Şti.; İstanbul. s:253-270. 4. Centers For Disease control and Prevention (CDC). PneumococcalDisease. http://www.cdc.gov/vaccines/pubs/pinkbook/pneumo. html 19.09.2016 tarihinde erişildi. 5. Johnson HL, Deloria-Knoll M, Levine OS, Stoszek SK, Freimanis Hance L, Reithinger R, et al. Systematic evaluation of serotypes causing invasive pneumococcaldisease among children under five: the pneumococcal global serotype project. PLoS Medicine, 2010, 7: pii: e1000348. 6. Ulusal Antimikrobiyal Direnç Surveyans Sistemi, 2013 Yılı Yıllık Raporu, Türkiye Halk Sağlığı Kurumu, Sağlık Bakanlığı Ankara, http://uamdss.thsk.gov.tr 19.09.2016 tarihinde erişildi. 7. Lim WS, Macfarlane JT, Boswell TC, Harrison TG, Rose D, Leinonen M et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: Implications for management guidelines. Thorax. 2001;56:296–301. doi: 10.1136/thorax. 56.4.296. 8. Woodhead M. Community-acquired pneumonia in Europe: Causative pathogens and resistance patterns.Eur. Respir. J. Suppl. 2002;36:20s–27s. doi: 10.1183/09031936.02.00702002. 9. T.C. Sağlık Bakanlığı Refik Saydam Hıfzıssıhha Merkezi Başkanlığı Hıfzıssıhha Mektebi Müdürlüğü, Başkent Üniversitesi . Ulusal hastalık yükü ve maliyet-etkililik projesi. Aralık 2004. Hastalık yükü final rapor . Aralık 2004. s:43 http://ekutuphane.tusak.gov.tr/kitaplar/turkiye_hastalik_yuku_calismasi. pdf 24.09.2016 tarihinde ulaşıldı 10 Talbot TR, Poehling KA, Hartert TV, Arbogast PG, Halasa NB, Edwards KM, et al. Seasonality of invasive pneumococcal disease: temporal relation to documentedinfluenza and respiratory syncytial viral circulation. American Journal of Medicine, 2005, 118:285-291. 11. Guillamet CV, Vazquez R, Noe J, Micek ST, Kollef MH.A cohort study of bacteremic pneumonia: The importance of antibiotic resistance and appropriate initial therapy? Medicine (Baltimore). 2016 Aug;95(35):e4708. doi: 10.1097/MD.0000000000004708. 12. World Health Organisation. Pneumococcal vaccines WHO positionpaper- 2012. http://www.who.int/wer/2012/wer8714.pdf?ua=1 20.09.2016 da erişildi 13. Schiffner-Rohe J, Witt A, Hemmerling J, von Eiff C, Leverkus FW. Efficacy of PPV23 in Preventing Pneumococcal Pneumonia in Adults at Increased Risk--A Systematic Reviewand Meta-Analysis. PLoS One. 2016 Jan 13;11(1):e0146338. doi: 10.1371/journal. pone.0146338. eCollection 2016. 14. Pichichero ME. Protein carriers of conjugate vaccines. Characteristics, development, and clinical trials Hum Vaccin Im munother. 2013 Dec 1; 9(12): 2505–2523.doi: 10.4161/hv.26109 15. Grijalva CG, Nuorti JP, Arbogast PG, Martin SW, Edwards KM, Griffin MR. Decline in pneumonia admissions after routine childhood immunization with pnemococcal conjugate vaccine in USA: a time series analysis. Lancet 2007;369:1179 16. Fireman B, Black SB, Shinefield Hr, Lee J, Lewis E, Ray P. Impact of pneumococcal conjugate vaccine on otitis media. Pediatr Infec Dis J 2003, 22:10 17. Madhi SA, Klugman KP, Vaccine Trialist group. A role for streptococcus pneumonia in virüs associated pnemonia. Nat Med 2004;10:811 18. de Roux A, Schmöle-Thoma B, Siber GR, Hackell JG, Kuhnke A, Ahlers N, et al. Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults: conjugate vaccine elicits improved antibacterial immune responses and immunological memory. Clin Infect Dis 2008;46:1015–23 19. Jackson LA, Gurtman A, van Cleeff M, Jansen KU, Jayawardene D, Devlin C,et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine compared to a 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naive adults. Vaccine 2013;31:3577-3584 20. Bonten M.J., Huijts S.M., Bolkenbaas M., Webber C., Patterson S., Gault S., et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N. Engl. J. Med. 2015;372:1114–1125. doi: 10.1056/NEJMoa1408544. CAPITA 21. Jackson LA, Gurtman A, Rice K, Pauksens K, Greenberg RN, Jones TR, et al. Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine in adults 70 years of age and older previously vaccinated with 23-valent pneumococcal polysaccharide vaccine. Vaccine 2013;31:3585-3593 22. Greenberg RN, Gurtman A, Frenck RW, Strout C, Jansen KU, Trammel J et al. Sequential administration of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in pneumococcal vaccine-naïve adults 60–64 years of age. Vaccine 2014;32:2364–74. 23. Jackson LA, Gurtman A, van Cleeff M, Frenck RW, Treanor J, Jansen KU et al. Influence of initial vaccination with 13-valent pneumococcal conjugate vaccine or 23-valent pneumococcal polysaccharide vaccine on anti-pneumococcal responses following subsequent pneumococcal vaccination in adults 50 years and older. Vaccine 2013;31:3594–602 24. Ishiguro T, Kagiyama N, Uozumi R, Odashima K, Kurashima K, Morita S, et al. Risk factors for the severity and mortality of pneumococcal pneumonia: Importance of premorbid patients' performance status. J Infect Chemother. 2016 Oct;22(10):685-91. doi: 10.1016/j.jiac.2016.07.008. 25. Schiffner-Rohe J, Witt A, Hemmerling J, von Eiff C, Leverkus FW. Efficacy of PPV23 in Preventing Pneumococcal Pneumonia in Adults at Increased Risk--A Systematic Reviewand Meta-Analysis. PLoS One. 2016 Jan 13;11(1):e0146338. doi: 10.1371/journal. pone.0146338. eCollection 2016. 26. La Torre G, Mannocci A, Colamesta V, D'Egidio V, Sestili C, Spadea A. Influenza and Pneumococcal Vaccination in Hematological Malignancies: a Systematic Review of Efficacy, Effectiveness, and Safety. Mediterr J Hematol Infect Dis. 2016 Sep 1;8(1):e2016044. doi: 10.4084/MJHID.2016.044. eCollection 2016. 27. Marrie TJ, Tyrrell GJ, Majumdar SR, Eurich DT.Asplenic patients and invasive pneumococcal disease-how bad is it these days? Int J Infect Dis. 2016 Aug 30;51:27-30. doi: 10.1016/j.ijid.2016.08.022. [Epub ahead of print] 28. Tomczyk S, Bennett NM, Stoecker C, Gierke R, Moore MR, Whitney CG, et al. Use of PCV-13 and PPSV-23 vaccine among adults aged 65 and older: recommendations of the ACIP(http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6337a4.ht m). MMWR. 2014;63(37);822-5. 29. Kobayashi M, Bennett NM, Gierke R, Almendares O, Moore MR, MD, Whitney CG et al. Intervals between PCV13 and PPSV23 vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2015;64:944–7.
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Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section makaleler
Authors

Hülya Akan This is me

Publication Date September 30, 2016
Published in Issue Year 2016 Volume: 8 Issue: 5

Cite

APA Akan, H. (2016). Erişkinlerde Pnömokok Bağışıklaması. Klinik Tıp Aile Hekimliği, 8(5), 51-54.
AMA Akan H. Erişkinlerde Pnömokok Bağışıklaması. Aile Hekimliği. September 2016;8(5):51-54.
Chicago Akan, Hülya. “Erişkinlerde Pnömokok Bağışıklaması”. Klinik Tıp Aile Hekimliği 8, no. 5 (September 2016): 51-54.
EndNote Akan H (September 1, 2016) Erişkinlerde Pnömokok Bağışıklaması. Klinik Tıp Aile Hekimliği 8 5 51–54.
IEEE H. Akan, “Erişkinlerde Pnömokok Bağışıklaması”, Aile Hekimliği, vol. 8, no. 5, pp. 51–54, 2016.
ISNAD Akan, Hülya. “Erişkinlerde Pnömokok Bağışıklaması”. Klinik Tıp Aile Hekimliği 8/5 (September 2016), 51-54.
JAMA Akan H. Erişkinlerde Pnömokok Bağışıklaması. Aile Hekimliği. 2016;8:51–54.
MLA Akan, Hülya. “Erişkinlerde Pnömokok Bağışıklaması”. Klinik Tıp Aile Hekimliği, vol. 8, no. 5, 2016, pp. 51-54.
Vancouver Akan H. Erişkinlerde Pnömokok Bağışıklaması. Aile Hekimliği. 2016;8(5):51-4.