New Development Models in Immunotherapy

Abstract

Abstract

In the treatment of allergic diseases, allergen specific immunotherapy (SIT) is theonly specific treatment method that provide cure and long term protective effect. Although SIT have been used over the past one hundred years, there are still some problems about side effects and efficacy of immunotherapy. Furthermore taking a longtime of treatment causes loss of labor and time, hence new studies on allergen models and use of administration of SIT  is made. In all of these administrations the standardization of allergen extract which has the most effective immun stimulation  concentration and lowest observed adverse effect level is important. There is a need forresearch about long term efficacy, safety, prevention asthma and new allergen sen-sitization of new developed immunotherapy models and allergen extract. This article reviews new developed immunotherapy materials and administration methods.

Keywords

• Allergy,immunotherapy,intralymphatic,epicutaneous,sublingual

Yeni Geliştirilen İmmunoterapi Modelleri

Abstract

Öz

Alerjen spesifik immünoterapi (SİT), alerjik hastalıkların tedavisinde kür sağlayan ve uzun süre koruyucu etkisi olan tek spesifik tedavi yöntemidir. Yüz yılı aşkınsüredir alerjik hastalıkların tedavisinde kullanılmasına rağmen günümüzde halen immunoterapi etkinliği ve yan etkilerine dair problemler yaşanmaktadır. Aynı zamanda uzun tedavi süresinin işgücü ve zaman kaybına yol açması, SİT için yeni uygulama yolları ve alerjen modelleri üzerinde çalışmalar yapılmasına neden olmaktadır.Tüm bu uygulamaların hepsinde immün sistemi en iyi uyarabilecek en az yan etkiye sahip doz ve konsantrasyonda alerjen ekstresinin standardizasyonu önem taşımaktadır. Yeni geliştirilen immunoterapi modelleri ve alerjen ekstrelerinin uzun dönemetkinlik, güvenilirlik, astım gelişiminin ve yeni alerjik duyarlanmaların önlenmesikonusunda yapılacak çalışmalara ihtiyaç bulunmaktadır. Bu makalede  yeni geliştirilen immünoterapi materyalleri ve yeni uygulama yöntemlerinden sözedilecektir.

Keywords

• Alerji,immunoterapi,intralenfatik,epikutanöz,sublingual

References

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