What is the Role of Probiotics in Preventing Hospital Infections?

Abstract

Abstract

Probiotics are defined as live microorganisms of human origin that are able totolerate the hostile gastrointestinal environment such that they persist in the loweralimentary tract to confer a health benefit to the host. Metaanalysis of RCT sho-wed that LGG at a dose of 109 CFU/day is effective in prevention of nosocomial diarrhea in children. In 2014 metaanalysis the use of probiotics decreased the incidence of VAP from 29 to 21 percent. However no significant differences in mortality, length of ICU stay, or duration of mechanical ventilation were detected. However quality of evidence is low.  Available results do not provide sufficient evidence to draw conclusions regarding the efficacy or safety of probiotics for the prevention of VAP.

Keywords

• Nosocomial diarrhea,ventila-tory associated pneumonia,probiotics

Hastane Enfeksiyonlarının Önlenmesinde Probiyotiklerin Rolü Nedir?

Öz

Öz

Probiyotikler yeterli miktarda alındığında konağın sindirim sisteminde yeterli sayıda kalabilen  ve konağa yarar sağlayabilen insan kaynaklı canlı mikroorganizmalardır.  Lactobacillus rhamnosus GG (LGG) en az 109 CFU/gün, hastane yatışı boyunca kullanıldığında nozokomiyal ishalin önlenmesinde etkili bulunmuştur. 2014 metaanalizinde probiyotiklerin kontrol grubıu ile karşılaştırıldığında VAP insidansını %29’dan %21’e azalttığı saptanmıştır.  Ancak yoğun bakım yatış süresinde ve mortalitede azalma bulunmamıştır. Hali hazırda probiyotiklerin VAP’ı önlemek amacıyla rutin olarak kullanımı önerilmemektedir

Anahtar Kelimeler

• Nozokomiyal ishal,ventilatörilişkili pnömoni,probiyotikler

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