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Bileşene Bağlı Tanı

Year 2017, Volume: 9 Issue: 2, 63 - 68, 15.03.2017

Abstract

Öz

Alerjenler, farklı alerjik özellik gösteren parçaların bir araya gelmesi ile oluşur.Bu parçaların bazıları, başka alerjenlerle ortaktır. Bu nedenle tüm alerjen ekstresinitest eden spesifik IgE ölçümlerinde ve prick deri testinde yanıltıcı sonuçlar çıkabilir. Özellikle çoklu alerjen duyarlığında bu ortak alerjen yapılar nedeniyle çapraz reaksiyonlar, yalancı pozitiflikler görülebilir. Alerjenleri bileşenlerine ayırarak türe özgü veya farklı türlerde ortak olan alerjenler saptanır. Buna; bileşene bağlı tanı (orijinal ismi  ile “Component Resolved-Diagnosis”; CRD) denir. CRD’nin özellikleri, nerelerde ve nasıl kullanıldığı, bu uygulamaların kliniğe yansımaları tartışılmıştır. Besin ve inhalan alerjenler ayrı ayrı incelenerek tanının doğrulanması, özelleştirilmesi ve doğru tedavinin yapılmasında kullanımı ve bu konuda son yıllarda yapılan araştırmaların sonuçları değerlendirilmiştir.

References

  • Kaynaklar 1.Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hil-ger C, HofmaierS,etal.Pediatr Allergy Immunol. 2016 May;27Suppl23:1-250. doi: 10.1111/pai.12563.EAACI MolecularAller-gologyUser's Guide. 2.Astım Alerji İmmünoloji 2016; 14; Ek sayı:1. Alerjen İmmüno-terapisi Ulusal Rehber 2016. Sin BA, Şahiner ÜM (eds). 3.Kleine-Tebbe J, Matricardi PM, Hamilton RG. AllergyWork-UpIn-cluding Component-ResolvedDiagnosis.HowtoMake Allergen-Spe-cific Immunotherapy More Specific. Immunol Allergy Clin N Am36 (2016) 191–203 http:// dx.doi.org /10.1016/j.iac.2015.08.012. 4.Lizaso MT, Garcia BE, Tabar AI, Lasa E, Echechipia S, Alva-rez MJ, et al. Comparison of conventionalandcomponent-resol-veddiagnosticsbytwodifferentmethods (Advia-Centaur/Microar-ray-ISAC) in pollenallergy. AnnAllergyAsthmaImmunol.2011;107(1):35-41. 5.Stringari G, Tripodi S, Caffarelli C, Dondi A, Asero R, DiRien-zoBusinco A, et al. Theeffect of component-resolveddiagnosis onspecificimmunotherapyprescription in childrenwith hay fever.JAllergy ClinImmunol. 2014 Jul;134(1):75-81. doi:10.1016/j.jaci.2014.01.042. Epub 2014 May 1. 6.Yılmaz EA, Saçkesen C. Besin alerjilerinde tanı yöntemleri .In:Şe-kerel BE (ed).Çocukluk çağında alerji astım immünoloji. ADA Ba-sın Yayın Ltd. Şti. Ankara (1.baskı) 2015, pp:667-680. 7.Vidal C, Lojo S, Juangorena M, Gonzalez-Quintela A.Association-BetweenAsthmaandSensitizationtoAllergens of Dermatophagoidesp-teronyssinus.J InvestigAllergolClinImmunol. 2016;26(5):304-309. doi:10.18176/jiaci.0048. Epub 2016 Jun 21. 8.Choopong J, Reamtong O, Sookrung N, Seesuay W, Indrawat-tana N, Sakolvaree Y, Chaicumpa W, Tungtrongchitr A.Proteo-me, Allergenome, andNovelAllergens of House Dust Mite, Der-matophagoidesfarinae.J ProteomeRes. 2016 Feb 5;15(2):422-30.doi: 10.1021/acs.jproteome.5b00663. Epub 2016 Jan 25. 9.Zeng G, Luo W, Zheng P, Wei N, Huang H, Sun B, Zhao X. Com-ponent-ResolvedDiagnosticStudy of DermatophagoidesPteronys-sinusMajorAllergenMolecules in a SouthernChineseCohort.J In-vestigAllergolClinImmunol. 2015;25(5):343-51. 10.vanErp FC, Klemans RJ, Meijer Y, van der Ent CK, Knulst AC.Using Component-ResolvedDiagnostics in the Management ofPeanut-AllergicPatients.CurrTreatOptions Allergy. 2016;3:169-180. Epub 2016 Apr 7. 11.Tuano KS, Davis CM. Utility of Component-ResolvedDiagnos-tics in Food Allergy.Curr Allergy AsthmaRep. 2015 Jun;15(6):32.doi: 10.1007/s11882-015-0534-0. 12.Sato S, Yanagida N, Ohtani K, Koike Y, Ebisawa M. A review ofbiomarkers for predictingclinicalre activitytofoodswith a focus onspecificimmunoglobulin E antibodies.CurrOpin Allergy ClinImmu-nol. 2015 Jun;15(3):250-8. doi: 10.1097/ACI. 00000000 00000162. 13.Eller E, Mortz CG, Bindslev-Jensen C. Cor a 14 is thesuperior-serological marker forhazelnut allergy in children, independentof concomitantpeanut allergy.Allergy. 2016 Apr;71(4):556-62.doi: 10.1111/all.12820. Epub 2016 Jan 19. 14.Burk CM, Kulis M, Leung N, Kim EH, Burks AW, Vickery BP.Utility of componentanalyses in subjectsundergoingsublingualim-munotherapyforpeanut allergy. (ClinExp Allergy. 2016Feb;46(2):347-53. doi: 10.1111/cea.12635. 15.Incorvaia C, Rapetti A, Aliani M, Castagneto C, Corso N, Landi M,et.al . Food allergy as defined by component resolved diagnosis.Recent Pat Inflamm Allergy DrugDiscov. 2014 Jan;8(1): 59-73. 16.Tasaniyananda N, Tungtrongchitr A, Seesuay W, Sakolvaree Y,Indrawattana N, Chaicumpa W, Sookrung N. A novelIgE-bindin-gepitope of catmajorallergen, Fel d 1.BiochemBiophysResCom-mun. 2016 Feb 12;470(3):593-8. doi: 10.1016/j.bbrc.2016.01.099.Epub 2016 Jan 18. 17.Karakoç GB. İnek sütü alerjisi. In:ŞekerelBE (ed).Çocukluk ça-ğında alerji astım immünoloji. ADA Basın Yayın Ltd. Şti. Anka-ra (1.baskı) 2015, pp:619-625. 18.Lomidze N, Gotua M .Patterns of sensitizationbyfoodandinhalant-components in Georgianpatients.GeorgianMed News. 2016Oct;(259):23-26. 19.Shirasaki H, Yamamoto T, Abe S, Kanaizumi E, Kikuchi M, HimiT.Clinicalbenefit of component-resolveddiagnosis in Japanese-birch-allergicpatientswith a convincinghistory of appleorpeachallergy.AurisNasusLarynx. 2016 Nov 2. pii: S0385-8146(16)30452-7. doi: 10.1016/j.anl.2016.10.004. [Epubahead of print] 20.Armentia A, Sanchís E, MonteroJAComponent-resolveddiagnos-tics in vernalconjunctivitis.CurrOpin Allergy ClinImmunol.2016 Oct;16(5):498-504. doi: 10. 109 7/A CI. 00 0 0 000000000296. 21.Cardona V, Ansotegui IJ. Component-resolveddiagnosis inanaphylaxis.CurrOpin Allergy ClinImmunol. 2016 Jun;16(3):244-9. doi: 10.1097/ACI.0000000000000261.

Component Resolved Dıagnosıs=CRD

Year 2017, Volume: 9 Issue: 2, 63 - 68, 15.03.2017

Abstract

Abstract

Allergenes are composed with the aggregation of fragments that show differen taller gicproperties. For this reason, mis leading results can be concluded with the measurement of specific IgE level sand skin pricktests. Especially in the sensitivity of multiple allergenes, cross reactivity and false positive results can be seen.  With the detachement of components, specific or different types of common allerge nesare determined and called componenre solved diagnosis (CRD). The properties of CRD, usageme thodsand clinical reflections of these practises have been discussed.Verification and specialization of the diagnosis with the examination of foodandinhalant allergenes, employement for the accurate treatment and the results  of researches on this topic were evaluated.

References

  • Kaynaklar 1.Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hil-ger C, HofmaierS,etal.Pediatr Allergy Immunol. 2016 May;27Suppl23:1-250. doi: 10.1111/pai.12563.EAACI MolecularAller-gologyUser's Guide. 2.Astım Alerji İmmünoloji 2016; 14; Ek sayı:1. Alerjen İmmüno-terapisi Ulusal Rehber 2016. Sin BA, Şahiner ÜM (eds). 3.Kleine-Tebbe J, Matricardi PM, Hamilton RG. AllergyWork-UpIn-cluding Component-ResolvedDiagnosis.HowtoMake Allergen-Spe-cific Immunotherapy More Specific. Immunol Allergy Clin N Am36 (2016) 191–203 http:// dx.doi.org /10.1016/j.iac.2015.08.012. 4.Lizaso MT, Garcia BE, Tabar AI, Lasa E, Echechipia S, Alva-rez MJ, et al. Comparison of conventionalandcomponent-resol-veddiagnosticsbytwodifferentmethods (Advia-Centaur/Microar-ray-ISAC) in pollenallergy. AnnAllergyAsthmaImmunol.2011;107(1):35-41. 5.Stringari G, Tripodi S, Caffarelli C, Dondi A, Asero R, DiRien-zoBusinco A, et al. Theeffect of component-resolveddiagnosis onspecificimmunotherapyprescription in childrenwith hay fever.JAllergy ClinImmunol. 2014 Jul;134(1):75-81. doi:10.1016/j.jaci.2014.01.042. Epub 2014 May 1. 6.Yılmaz EA, Saçkesen C. Besin alerjilerinde tanı yöntemleri .In:Şe-kerel BE (ed).Çocukluk çağında alerji astım immünoloji. ADA Ba-sın Yayın Ltd. Şti. Ankara (1.baskı) 2015, pp:667-680. 7.Vidal C, Lojo S, Juangorena M, Gonzalez-Quintela A.Association-BetweenAsthmaandSensitizationtoAllergens of Dermatophagoidesp-teronyssinus.J InvestigAllergolClinImmunol. 2016;26(5):304-309. doi:10.18176/jiaci.0048. Epub 2016 Jun 21. 8.Choopong J, Reamtong O, Sookrung N, Seesuay W, Indrawat-tana N, Sakolvaree Y, Chaicumpa W, Tungtrongchitr A.Proteo-me, Allergenome, andNovelAllergens of House Dust Mite, Der-matophagoidesfarinae.J ProteomeRes. 2016 Feb 5;15(2):422-30.doi: 10.1021/acs.jproteome.5b00663. Epub 2016 Jan 25. 9.Zeng G, Luo W, Zheng P, Wei N, Huang H, Sun B, Zhao X. Com-ponent-ResolvedDiagnosticStudy of DermatophagoidesPteronys-sinusMajorAllergenMolecules in a SouthernChineseCohort.J In-vestigAllergolClinImmunol. 2015;25(5):343-51. 10.vanErp FC, Klemans RJ, Meijer Y, van der Ent CK, Knulst AC.Using Component-ResolvedDiagnostics in the Management ofPeanut-AllergicPatients.CurrTreatOptions Allergy. 2016;3:169-180. Epub 2016 Apr 7. 11.Tuano KS, Davis CM. Utility of Component-ResolvedDiagnos-tics in Food Allergy.Curr Allergy AsthmaRep. 2015 Jun;15(6):32.doi: 10.1007/s11882-015-0534-0. 12.Sato S, Yanagida N, Ohtani K, Koike Y, Ebisawa M. A review ofbiomarkers for predictingclinicalre activitytofoodswith a focus onspecificimmunoglobulin E antibodies.CurrOpin Allergy ClinImmu-nol. 2015 Jun;15(3):250-8. doi: 10.1097/ACI. 00000000 00000162. 13.Eller E, Mortz CG, Bindslev-Jensen C. Cor a 14 is thesuperior-serological marker forhazelnut allergy in children, independentof concomitantpeanut allergy.Allergy. 2016 Apr;71(4):556-62.doi: 10.1111/all.12820. Epub 2016 Jan 19. 14.Burk CM, Kulis M, Leung N, Kim EH, Burks AW, Vickery BP.Utility of componentanalyses in subjectsundergoingsublingualim-munotherapyforpeanut allergy. (ClinExp Allergy. 2016Feb;46(2):347-53. doi: 10.1111/cea.12635. 15.Incorvaia C, Rapetti A, Aliani M, Castagneto C, Corso N, Landi M,et.al . Food allergy as defined by component resolved diagnosis.Recent Pat Inflamm Allergy DrugDiscov. 2014 Jan;8(1): 59-73. 16.Tasaniyananda N, Tungtrongchitr A, Seesuay W, Sakolvaree Y,Indrawattana N, Chaicumpa W, Sookrung N. A novelIgE-bindin-gepitope of catmajorallergen, Fel d 1.BiochemBiophysResCom-mun. 2016 Feb 12;470(3):593-8. doi: 10.1016/j.bbrc.2016.01.099.Epub 2016 Jan 18. 17.Karakoç GB. İnek sütü alerjisi. In:ŞekerelBE (ed).Çocukluk ça-ğında alerji astım immünoloji. ADA Basın Yayın Ltd. Şti. Anka-ra (1.baskı) 2015, pp:619-625. 18.Lomidze N, Gotua M .Patterns of sensitizationbyfoodandinhalant-components in Georgianpatients.GeorgianMed News. 2016Oct;(259):23-26. 19.Shirasaki H, Yamamoto T, Abe S, Kanaizumi E, Kikuchi M, HimiT.Clinicalbenefit of component-resolveddiagnosis in Japanese-birch-allergicpatientswith a convincinghistory of appleorpeachallergy.AurisNasusLarynx. 2016 Nov 2. pii: S0385-8146(16)30452-7. doi: 10.1016/j.anl.2016.10.004. [Epubahead of print] 20.Armentia A, Sanchís E, MonteroJAComponent-resolveddiagnos-tics in vernalconjunctivitis.CurrOpin Allergy ClinImmunol.2016 Oct;16(5):498-504. doi: 10. 109 7/A CI. 00 0 0 000000000296. 21.Cardona V, Ansotegui IJ. Component-resolveddiagnosis inanaphylaxis.CurrOpin Allergy ClinImmunol. 2016 Jun;16(3):244-9. doi: 10.1097/ACI.0000000000000261.
There are 1 citations in total.

Details

Primary Language Turkish
Journal Section makale
Authors

Prof. Dr. Reha Cengizlier

Publication Date March 15, 2017
Published in Issue Year 2017 Volume: 9 Issue: 2

Cite

APA Cengizlier, P. D. R. (2017). Bileşene Bağlı Tanı. Klinik Tıp Pediatri Dergisi, 9(2), 63-68.
AMA Cengizlier PDR. Bileşene Bağlı Tanı. Pediatri. March 2017;9(2):63-68.
Chicago Cengizlier, Prof. Dr. Reha. “Bileşene Bağlı Tanı”. Klinik Tıp Pediatri Dergisi 9, no. 2 (March 2017): 63-68.
EndNote Cengizlier PDR (March 1, 2017) Bileşene Bağlı Tanı. Klinik Tıp Pediatri Dergisi 9 2 63–68.
IEEE P. D. R. Cengizlier, “Bileşene Bağlı Tanı”, Pediatri, vol. 9, no. 2, pp. 63–68, 2017.
ISNAD Cengizlier, Prof. Dr. Reha. “Bileşene Bağlı Tanı”. Klinik Tıp Pediatri Dergisi 9/2 (March 2017), 63-68.
JAMA Cengizlier PDR. Bileşene Bağlı Tanı. Pediatri. 2017;9:63–68.
MLA Cengizlier, Prof. Dr. Reha. “Bileşene Bağlı Tanı”. Klinik Tıp Pediatri Dergisi, vol. 9, no. 2, 2017, pp. 63-68.
Vancouver Cengizlier PDR. Bileşene Bağlı Tanı. Pediatri. 2017;9(2):63-8.