Review
BibTex RIS Cite

New Perspective on Asthma Pathogenesis: Epithelial Barrier Function and Dysfunction

Year 2017, Volume: 9 Issue: 2, 194 - 198, 15.03.2017

Abstract

References

  • Kaynaklar 1.2014 GINA REPORT, Global strategy for asthma managementand prevention. Updated December 2011. Available from:http://www.ginasthma.org/GINA-Report,-Global-Strategy-for-Asthma-Management-and-Prevention 2.Heijink IH, Nawijn MC, Hackett TL. Airway epithelial barrier func-tion regulates the pathogenesis of allergic asthma. Clin Exp Al-lergy. 2014;44(5):620-30. 3.Blume C, Swindle EJ, Gilles S, Traidl-Hoffmann C, Davies DE.Low molecularweight components of pollen alter bronchial epit-helial barrier functions. Tissue Barriers. 2015;3:e1062316. 4.Moheimani F, Hsu AC, Reid AT, Williams T, Kicic A, Stick SM,et al. The genetic and epigenetic landscapes of the epithelium inasthma. Respir Res. 2016;17(1):119. 5.Bourdin A, Gras D, Vachier I, Chanez P. Upper airway x 1: al-lergic rhinitis and asthma: united disease through epithelial cells.Thorax. 2009;64:999-1004. 6.Niessen CM. Tight junctions/adherens junctions: basic structu-re and function. J Invest Dermatol. 2007; 127: 2525-32. 7.Effros RM, Nagaraj H. Asthma: new developments concerningimmune mechanisms, diagnosis and treatment. Curr Opin PulmMed. 2007; 13: 37-43. 8.Holgate ST. The sentinel role of the airway epithelium in asth-ma pathogenesis. Immunol Rev. 2011; 242: 205-19. 9.Tsicopoulos A, de Nadai P, Glineur C. Environmental and geneticcontribution in airway epithelial barrier in asthma pathogenesis. CurrOpin Allergy Clin Immunol. 2013;13(5):495-9. 10.Lambrecht BN, Hammad H. Allergens and the airway epitheli-um response: gateway to allergic sensitization. J Allergy Clin Im-munol. 2014;134(3):499-507 11.Proud D, Leigh R. Epithelial cells and airway diseases. Immu-nol Rev. 2011; 242: 186-204. 12.Ganesan S, Comstock AT, Sajjan US. Barrier function of airwaytractepithelium. Tissue Barriers. 2013;1(4):e24997 13.Loxham M, Davies DE, Blume C. Epithelial function anddysfunction in asthma. Clin Exp Allergy. 2014;44:1299-313. 14.Nawijn MC, Hackett TL, Postma DS, van Oosterhout AJ, HeijinkIH. E-cadherin: gatekeeper of airway mucosa and allergic sen-sitization. Trends Immunol. 2011; 32: 248-55 15.Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD. The air-way epithelium: more than just a structural barrier. Ther Adv Res-pir Dis. 2011; 5: 255-73 16.Knight DA, Stick SM, Hackett TL. Defective function at the epit-helial junction: a novel therapeutic frontier in asthma? J AllergyClin Immunol. 2011; 128: 557-8. 17.Swindle EJ, Collins JE, Davies DE. Breakdown in epithelial bar-rier function in patients with asthma: identification of novel thera-peutic approaches. J Allergy Clin Immunol. 2009; 124: 23-34. 18.Goto Y, Uchida Y, Nomura A, Sakamoto T, Ishii Y, MorishimaY, et al. Dislocation of E-cadherin in the airway epithelium du-ring an antigen-induced asthmatic response. Am J Respir Cell MolBiol. 2000; 23: 712-8. 19.de Boer WI, Sharma HS, Baelemans SM, Hoogsteden HC, Lam-brecht BN, Braunstahl GJ. Altered expression of epithelialjunctional proteins in atopic asthma: possible role in inflamma-tion. Can J Physiol Pharmacol. 2008; 86: 105-12. 20.Georas SN, Rezaee F. Epithelial barrier function: at the frontline of asthma immunology and allergic airway inflammation. JAllergy Clin Immunol. 2014;134:509-20. 21.Proud D. Biology of Epithelial Cells. In: Adkinson NF, Bochner BS,Busse WW, editors. Middleton's Allergy: Principles and Practice. 7thedition. China: Mosby Elsevier Publishers; 2009. p. 373-86. 22.Blume C, Swindle EJ, Dennison P, Jayasekera NP, Dudley S, MonkP,et al. Barrier responses of human bronchial epithelial cells tograss pollen exposure. Eur Respir J. 2013;42:87-97. 23.Yuksel H, Turkeli A, Taneli F, Horasan GD, Kanik ET, Kizilka-ya M, et al. E-cadherin as an epithelial barrier protein in exha-led breath condensate. J Breath Res. 2014;8:046006.24.Holgate ST. Innate and adaptive immune responses in asthma.Nat Med. 2012; 18: 673-83.25.Vinhas R, Cortes L, Cardoso I, Mendes VM, Manadas B, Todo-BomA, et al. Pollen proteases compromise the airway epithelial bar-rier through degradation of transmembran eadhesion proteins andlung bioactive peptides. Allergy. 2011; 66: 1088-98.26.Heijink IH, van Oosterhout A, Kapus A. Epidermal growth fac-tor receptor signalling contributes to house dust mite-induced epit-helial barrier dysfunction. Eur Respir J. 2010; 36: 1016-26. 27.Winter MC, Shasby SS, Ries DR, Shasby DM. PAR2 activationinterrupts E-cadherin adhesion and compromises the airway epit-helial barrier: protective effect of beta-agonists. Am J Physiol LungCell Mol Physiol. 2006; 291: 628-35. 28.Heijink IH, Postma DS, Noordhoek JA, Broekema M, Kapus A.House dust mite-promoted epithelial-to-mesenchymal transitionin human bronchial epithelium. Am J Respir Cell Mol Biol. 2010;42: 69-79. 29.Gershwin LJ. Effects of allergenic extracts on airway epitheli-um. Curr Allergy Asthma Rep. 2007; 7: 357-62 30.Bartis D, Mise N, Mahida RY, Eickelberg O, Thickett DR. Epit-helial-mesenchymal transition in lung development and disease:does it exist and is it important? Thorax 2014;69:760-5. 31.Baarsma HA, Menzen MH, Halayko AJ, Meurs H, Kerstjens HA,Gosens R. β-Catenin signaling is required for TGF-β1-inducedextracellular matrix production by airway smooth muscle cells.Am J Physiol Lung Cell Mol Physiol. 2011;301:L956-65. 32.Masszi A, Fan L, Rosivall L, McCulloch CA, Rotstein OD, Muc-si I,et al: Integrity of cell-cell contacts is a critical regulator ofTGF-beta 1-induced epithelial-to-myofibroblast transition:role for beta-catenin. Am J Pathol 2004, 165:1955-1967. 33.Lampugnani MG. Endothelial cell-to-cell junctions: adhesion andsignaling in physiology and pathology. Cold Spring Harb Pers-pect Med. 2012;2(10).

Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu ve Disfonksiyonu

Year 2017, Volume: 9 Issue: 2, 194 - 198, 15.03.2017

Abstract

ÖzHavayolu epiteli başlıca dış ve iç oratm arasında fiziksel bir bariyer olarak işlev görmektedir. Epitelyal bariyer fonksiyonu sıkı bağlar, adherans junctionlar ve desmozomların uygun hücre hücre bağlantılarıyla sürdürülür.  Astımda epitelin bariyer fonksiyonunun bozulduğu epitelyal frajilitenin arttığı görülmektedir. Epitelyal bariyer fonksiyonunda bozulma sonucu inhalen allerjenler, virüsler ve diğer çevreseletkenlerin submukozada antijen sunan hücreye erişiminin artması, Th2 tip aracılı immün yanıtı uyarılmasına ve epitelyel mezenşimal transisyon (EMT) uyarılmasındaönemli rol oynar. Genetik yapımız, astımlı epitel hücrelerinde değiştirilmiş bir sitokin salınmasının bir nedeni olabilir. Böylelikle astım patogenizinde hava yolu epi-teli bariyer bariyeri ve mediatör özellikleri ile patogenez ve tedavi yeni bir bakış açısı sağlamaktadır.

References

  • Kaynaklar 1.2014 GINA REPORT, Global strategy for asthma managementand prevention. Updated December 2011. Available from:http://www.ginasthma.org/GINA-Report,-Global-Strategy-for-Asthma-Management-and-Prevention 2.Heijink IH, Nawijn MC, Hackett TL. Airway epithelial barrier func-tion regulates the pathogenesis of allergic asthma. Clin Exp Al-lergy. 2014;44(5):620-30. 3.Blume C, Swindle EJ, Gilles S, Traidl-Hoffmann C, Davies DE.Low molecularweight components of pollen alter bronchial epit-helial barrier functions. Tissue Barriers. 2015;3:e1062316. 4.Moheimani F, Hsu AC, Reid AT, Williams T, Kicic A, Stick SM,et al. The genetic and epigenetic landscapes of the epithelium inasthma. Respir Res. 2016;17(1):119. 5.Bourdin A, Gras D, Vachier I, Chanez P. Upper airway x 1: al-lergic rhinitis and asthma: united disease through epithelial cells.Thorax. 2009;64:999-1004. 6.Niessen CM. Tight junctions/adherens junctions: basic structu-re and function. J Invest Dermatol. 2007; 127: 2525-32. 7.Effros RM, Nagaraj H. Asthma: new developments concerningimmune mechanisms, diagnosis and treatment. Curr Opin PulmMed. 2007; 13: 37-43. 8.Holgate ST. The sentinel role of the airway epithelium in asth-ma pathogenesis. Immunol Rev. 2011; 242: 205-19. 9.Tsicopoulos A, de Nadai P, Glineur C. Environmental and geneticcontribution in airway epithelial barrier in asthma pathogenesis. CurrOpin Allergy Clin Immunol. 2013;13(5):495-9. 10.Lambrecht BN, Hammad H. Allergens and the airway epitheli-um response: gateway to allergic sensitization. J Allergy Clin Im-munol. 2014;134(3):499-507 11.Proud D, Leigh R. Epithelial cells and airway diseases. Immu-nol Rev. 2011; 242: 186-204. 12.Ganesan S, Comstock AT, Sajjan US. Barrier function of airwaytractepithelium. Tissue Barriers. 2013;1(4):e24997 13.Loxham M, Davies DE, Blume C. Epithelial function anddysfunction in asthma. Clin Exp Allergy. 2014;44:1299-313. 14.Nawijn MC, Hackett TL, Postma DS, van Oosterhout AJ, HeijinkIH. E-cadherin: gatekeeper of airway mucosa and allergic sen-sitization. Trends Immunol. 2011; 32: 248-55 15.Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD. The air-way epithelium: more than just a structural barrier. Ther Adv Res-pir Dis. 2011; 5: 255-73 16.Knight DA, Stick SM, Hackett TL. Defective function at the epit-helial junction: a novel therapeutic frontier in asthma? J AllergyClin Immunol. 2011; 128: 557-8. 17.Swindle EJ, Collins JE, Davies DE. Breakdown in epithelial bar-rier function in patients with asthma: identification of novel thera-peutic approaches. J Allergy Clin Immunol. 2009; 124: 23-34. 18.Goto Y, Uchida Y, Nomura A, Sakamoto T, Ishii Y, MorishimaY, et al. Dislocation of E-cadherin in the airway epithelium du-ring an antigen-induced asthmatic response. Am J Respir Cell MolBiol. 2000; 23: 712-8. 19.de Boer WI, Sharma HS, Baelemans SM, Hoogsteden HC, Lam-brecht BN, Braunstahl GJ. Altered expression of epithelialjunctional proteins in atopic asthma: possible role in inflamma-tion. Can J Physiol Pharmacol. 2008; 86: 105-12. 20.Georas SN, Rezaee F. Epithelial barrier function: at the frontline of asthma immunology and allergic airway inflammation. JAllergy Clin Immunol. 2014;134:509-20. 21.Proud D. Biology of Epithelial Cells. In: Adkinson NF, Bochner BS,Busse WW, editors. Middleton's Allergy: Principles and Practice. 7thedition. China: Mosby Elsevier Publishers; 2009. p. 373-86. 22.Blume C, Swindle EJ, Dennison P, Jayasekera NP, Dudley S, MonkP,et al. Barrier responses of human bronchial epithelial cells tograss pollen exposure. Eur Respir J. 2013;42:87-97. 23.Yuksel H, Turkeli A, Taneli F, Horasan GD, Kanik ET, Kizilka-ya M, et al. E-cadherin as an epithelial barrier protein in exha-led breath condensate. J Breath Res. 2014;8:046006.24.Holgate ST. Innate and adaptive immune responses in asthma.Nat Med. 2012; 18: 673-83.25.Vinhas R, Cortes L, Cardoso I, Mendes VM, Manadas B, Todo-BomA, et al. Pollen proteases compromise the airway epithelial bar-rier through degradation of transmembran eadhesion proteins andlung bioactive peptides. Allergy. 2011; 66: 1088-98.26.Heijink IH, van Oosterhout A, Kapus A. Epidermal growth fac-tor receptor signalling contributes to house dust mite-induced epit-helial barrier dysfunction. Eur Respir J. 2010; 36: 1016-26. 27.Winter MC, Shasby SS, Ries DR, Shasby DM. PAR2 activationinterrupts E-cadherin adhesion and compromises the airway epit-helial barrier: protective effect of beta-agonists. Am J Physiol LungCell Mol Physiol. 2006; 291: 628-35. 28.Heijink IH, Postma DS, Noordhoek JA, Broekema M, Kapus A.House dust mite-promoted epithelial-to-mesenchymal transitionin human bronchial epithelium. Am J Respir Cell Mol Biol. 2010;42: 69-79. 29.Gershwin LJ. Effects of allergenic extracts on airway epitheli-um. Curr Allergy Asthma Rep. 2007; 7: 357-62 30.Bartis D, Mise N, Mahida RY, Eickelberg O, Thickett DR. Epit-helial-mesenchymal transition in lung development and disease:does it exist and is it important? Thorax 2014;69:760-5. 31.Baarsma HA, Menzen MH, Halayko AJ, Meurs H, Kerstjens HA,Gosens R. β-Catenin signaling is required for TGF-β1-inducedextracellular matrix production by airway smooth muscle cells.Am J Physiol Lung Cell Mol Physiol. 2011;301:L956-65. 32.Masszi A, Fan L, Rosivall L, McCulloch CA, Rotstein OD, Muc-si I,et al: Integrity of cell-cell contacts is a critical regulator ofTGF-beta 1-induced epithelial-to-myofibroblast transition:role for beta-catenin. Am J Pathol 2004, 165:1955-1967. 33.Lampugnani MG. Endothelial cell-to-cell junctions: adhesion andsignaling in physiology and pathology. Cold Spring Harb Pers-pect Med. 2012;2(10).
There are 1 citations in total.

Details

Primary Language Turkish
Journal Section makale
Authors

Prof. Dr. Hasan Yüksel This is me

Publication Date March 15, 2017
Published in Issue Year 2017 Volume: 9 Issue: 2

Cite

APA Yüksel, P. D. H. (2017). Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu ve Disfonksiyonu. Klinik Tıp Pediatri Dergisi, 9(2), 194-198.
AMA Yüksel PDH. Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu ve Disfonksiyonu. Pediatri. March 2017;9(2):194-198.
Chicago Yüksel, Prof. Dr. Hasan. “Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu Ve Disfonksiyonu”. Klinik Tıp Pediatri Dergisi 9, no. 2 (March 2017): 194-98.
EndNote Yüksel PDH (March 1, 2017) Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu ve Disfonksiyonu. Klinik Tıp Pediatri Dergisi 9 2 194–198.
IEEE P. D. H. Yüksel, “Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu ve Disfonksiyonu”, Pediatri, vol. 9, no. 2, pp. 194–198, 2017.
ISNAD Yüksel, Prof. Dr. Hasan. “Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu Ve Disfonksiyonu”. Klinik Tıp Pediatri Dergisi 9/2 (March 2017), 194-198.
JAMA Yüksel PDH. Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu ve Disfonksiyonu. Pediatri. 2017;9:194–198.
MLA Yüksel, Prof. Dr. Hasan. “Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu Ve Disfonksiyonu”. Klinik Tıp Pediatri Dergisi, vol. 9, no. 2, 2017, pp. 194-8.
Vancouver Yüksel PDH. Astım Patogenezine Yeni Bir Bakış Açısı: Epitel Bariyer Fonksiyonu ve Disfonksiyonu. Pediatri. 2017;9(2):194-8.