Flu

Year 2017, Volume: 9 Issue: 5, 1 - 7, 10.09.2017

Uzm. Dr. Aysun Yahşi

Abstract

Abstract

Influenza is a respiratory tract infection due to influenza viruses. It ranges froma mild upper respiratory tract infection to a severe lower respiratory tract infection causing death. Influenza typically begins with sudden onset of fever, chills, headache, diffuse myalgia and cough. Influenza viruses are Orthomyxo viruses of generaor types (A, B, C) and influenza D viruses that have been identified in recent years.The most common types of illness in humans are influenza A and B. Influenza maybe seen with the pandemic. The last influenza pandemic was seen in 2009 with H1N1.Influenza is spread from person to person, primarily by respiratory tract droplets created by coughing or sneezing. Influenza therapy is includes supportive care and an-tiviral treatment. Initiation of antiviral therapy early (especially within the first 48hours) in patients with complicated and severe disease, high risk group patients and hospitalized patients is very important for prognosis. The main way of protection isvaccination. The annual influenza vaccine is recommended for all age groups olderthan 6 months.

Keywords

Influenza, pandemic, influen-za vaccine

Grip

Abstract

Öz

Grip, influenza virusuna bağlı bir solunum yolu enfeksiyonudur. Hafif bir üst so-lunum yolu enfeksiyonundan, ölüme neden olan ağır bir alt solunum yolu enfeksiyonuna kadar değişen klinik gösterir. Grip, tipik olarak ani başlayan ateş, titreme,baş ağrısı, yaygın kas ağrısı ve öksürük ile karakterize solunum yolu enfeksiyonudur. İnfluenza virusları, Orthomyxoviridae ailesi içerisinde yer alan influenza A, influenza B ve influenza C ve son yıllarda tanımlanan influenza D’dir. İnsanlarda ensık hastalık yapan tipler influenza A ve B’dir. İnfluenza pandemiler ile seyredebilir. En son influenza pandemisi 2009 yılında H1N1 ile görülmüştür. İnfluenza enfeksiyonu, kişiden kişiye primer olarak öksürük veya hapşırma ile solunum yolu damlacıkları yoluyla bulaşır.  İnfluenza tedavisi; destek tedavisi ve antiviral tedaviden oluşmaktadır. Komplike ve ağır hastalık varlığında, yüksek risk grubu hastalarda, hastanede yatan hastalarda erken (özellikle ilk 48 saat içinde) antiviral tedavi başlanması prognozda çok önemlidir. Esas korunma yolu aşılanmadır. Yaşı 6 aydan büyük tüm yaş gruplarına yıllık influenza aşısı önerilmektedir.

Keywords

Grip, pandemi, influenza aşısı

References

• Kaynaklar 1.Nandhini G, Sujatha S. Epidemiology of influenza viruses from2009 to 2013- A sentinel surveillance report from Union ter-ritory of Puducherry, India. Asian Pacific Journal of Tropi-cal Medicine 2015; 8 (9): 718-23. 2.Hause BM, Huntimer L, Falkenberg S, Henningson J, Lech-tenberg K, Halbur T. An inactivated influenza D virus vacci-ne partially protects cattle from respiratory disease caused byhomologous challenge. Vet Microbiol 2017; 199: 47-53. 3.American Academy of Pediatrics. Influenza. In: Pickering LK,Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2015 Reportof the Committee on Infectious Diseases, 30th ed. Elk Grove Vil-lage, IL: American Academy of Pediatrics, 2015: 476-93. 4.Johnson NP, Mueller J. Updating the accounts: global mor-tality of the 1918-1920 “Spanish” influenza pandemic. BullHist Med 2002; 76: 105-15. 5.Pappas DE, Hendley JO. Influenza. In: Kliegman RM, Stan-ton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pe-diatrics, 20th ed. Philadelphia: Elsevier, 2016: 1598-603. 6.Kumar V. Influenza in children. Indian J Pediatr 2017; 84:139-43. 7.Cherry JD, Mundi J, Shapiro NL. Influenza. In: Cherry JD,Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, eds. Fei-gin and Cherry’s Textbook of Pediatric Infectious Diseases,7th ed. Philadelphia: Elsevier Saunders, 2014: 2326-59. 8.Nicholson KG, Wood JM, Zambon M. Influenza. Lancet 2003;362: 1733-45. 9.http://www.who.int/influenza/gisrs_laboratory/flunet/en 10.Lau LL, Nishiura H, Kelly H, et al. Household transmissionof 2009 pandemic influenza A (H1N1): a systematic review andmeta-analysis. Epidemiology 2012; 23: 531-42. 11.Lessler J, Reich NG, Brookmeyer R, et al. Incubation peri-ods of acute respiratory viral infections: a systematic review.Lancet Infect Dis 2009; 9: 291-300. 12.Li CC, Wang L, Eng HL, et al. Correlation of pandemic (H1N1)2009 viral load with disease severity and prolonged viral shed-ding in children. Emerg Infect Dis 2010; 16: 1265-72. 13.Saha A, Jha N, Dubey NK, Gupta VK, Kalaivani M. Swine-origin influenza A (H1N1) in Indian children. Ann Trop Pae-diatr 2010; 30 (1): 51-55. 14.Long SS, Pickering LK, Prober CG. Principles and Practi-ce of Pediatric Infectious Diseases, 4th ed. Philadelphia: Els-evier, 2012: 1149-59. 15.Çiftçi E, Karbuz A, Kendirli T. Influenza and the use of osel-tamivir in children. Turk Pediatri Ars 2016; 51 (2): 63-71. 16.Buck ML. An Update on Oseltamivir Use in Infants and Child-ren. Pediatr Pharm. Children’s Medical Center, University ofVirginia. 2012; 18 (9). 17.Smith JR, Rayner CR, Donner B, Wollenhaupt M, Klumpp K,Dutkowski R. Oseltamivir in seasonal, pandemic, and avianinfluenza: a comprehensive review of 10-years clinical expe-rience. Adv Ther 2011; 28: 927-59. 18.Baik SH, Jeong HS, Kim SJ, Yoon YK, Sohn JW, Kim MJ. ACase of Influenza Associated Fulminant Myocarditis Success-fully Treated with Intravenous Peramivir. Infect Chemother2015; 47: 272-77. 19.Kendirli T, Demirkol D, Yildizdas D, et al. Critically ill child-ren with pandemic influenza (H1N1) in pediatric intensive careunits in Turkey. Pediatr Crit Care Med 2012; 13: e11-7. 20.Libster R, Bugna J, Coviello S, et al. Pediatric hospitaliza-tions associated with 2009 pandemic influenza A (H1N1) inArgentina. N Engl J Med 2010; 362: 45-55. 21.Miller RR 3rd, Markewitz BA, Rolfs RT, et al. Clinical fin-dings and demographic factors associated with ICU admis-sion in Utah due to novel 2009 influenza A (H1N1) infection.Chest 2010; 137: 752-58. 22.Lockman JL, Fischer WA, Perl TM, et al. The critically ill childwith novel H1N1 influenza A: A case series. Pediatric Crit CareMed 2010; 11: 173-78. 23.Torres SF, Iolster T, Schnitzler EJ, et al. High mortality inpatients with influenza A pH1N1 2009 admitted to a pediat-ric intensive care unit: a predictive model of mortality. Pedi-atr Crit Care Med 2012; 13: e78-83. 24.Lee N, Cockram CS, Chan PKS, et al. Antiviral treatment forpatients hospitalized with severe influenza infection may af-fect clinical outcomes. Clin Infect Dis 2008; 46: 1323-24.