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Drug Use İn Breastfeeding Mothers İn The Neonatal Period And The Effects To Neonates

Year 2019, Volume: 11 Issue: 4, 205 - 212, 03.07.2019

Abstract

Abstract

Breast milk is a unique food that has many benefits for both baby and mother. Such an important food source can discontinued unnecessarily sometimes by unconscious health care workers in this regard, sometimes by families with the concern that the drugs were used by the mother for various reasons may transition to the breast milk and adversely affect the baby. However, there are many factors that determine the transition of drugs to the breast milk and most of the drugs have not been reported to have any adverse effects in the neonatal period. In this article, it is aimed to raise awareness of health care workers about the unnecessary discontinuation of breast milk by reviewing the use of the drugs in breastfeeding mothers and their effects on newborns.

References

  • Kaynaklar 1.Lawrence RA, Lawrence RM. Breastfeeding: A Guide for the MedicalProfession. “Medications, Herbal Preparations, and Natural Productsin Breast Milk”. 8th Edition. Philadelphia, Elsevier, 2015:364-406. 2.Mcclary MD. Principles of Drug Use During Lactation. In: MartinRJ, Fanaroff AA, Walsh MC, eds, Fanaroff and Martin’s NeonatalPerinatal Medicine. 10th edition, Vol.2. Philadelphia: Saunders.2015;660-4. 3.Rowe H, Baker T, Hale TW. Maternal medication, drug use, and bre-astfeeding. Adolesc Psychiatr Clin N Am. 2015;24:1-20. 4.Anderson PO, Pochop SL, Manoguerra AS. Adverse drug reactionsin breastfed infants: less than imagined. Clin Pediatr (Phila).2003;42:325-40. 5.Passmore CM, McElnay JC, Rainey EA, et al. Metronidazole exc-retion in human milk and its effect on the suckling neonate. Br J ClinPharmacol. 1988;26:45–51. 6.Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolicacidosis caused by salicylate. Clin Pediatr (Phila). 1981;20:53-4. 7.Koren G, Cairns J, Chitayat D, et al. Pharmacogenetics of morphi-ne poisoning in a breastfed neonate of a codeine-prescribed mother.Lancet. 2006;368:704. 8.American Academy of Pediatrics Committee on Drugs. Transfer of drugsand other chemicals into human milk. Pediatrics. 2001;108:776-89. 9.Hudzik B, Zubelewicz-Szkodzinska B. Antithyroid drugs during bre-astfeeding. Clin Endocrinol (Oxf). 2016;85:827-30. 10.Prednisone. Drugs and Lactation Database (LactMed) [Internet]. Bet-hesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000136 11.Prednisolone. Drugs and Lactation Database (LactMed) [Internet].Bethesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000135 12.Methylprednisolone. Drugs and Lactation Database (LactMed)[Internet]. Bethesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000087 13.Dexamethasone. Drugs and Lactation Database (LactMed) [Inter-net]. Bethesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000826 14.Butler DC, Heller MM, Murase JE. Safety of dermatologic medica-tions in pregnancy and lactation: Part II. Lactation. J Am Acad Der-matol. 2014;70:417-27. 15.De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hyper-tension with mineralocorticoid excess in an infant. Helv Paediatr Acta.1983;38:185-9. 16.Stahl MM, Neiderud J, Vinge E. Thrombocytopenic purpura and ane-mia in a breast-fed infant whose mother was treated with valproicacid. J Pediatr. 1997;130:1001-3. 17.Frey B, Braegger CP, Ghelfi D. Neonatal cholestatic hepatitis fromcarbamazepine exposure during pregnancy and breast feeding. AnnPharmacother. 2002;36:644-7. 18.Kronenfeld N, Berlin M, Shaniv D, Berkovitch M. Use of Psychot-ropic Medications in Breastfeeding Women. Birth Defects Res.2017;109:957-97. 19.Spencer JP, Gonzalez LS 3rd, Barnhart DJ. Medications in the breast-feeding mother. Am Fam Physician. 2001;64:119-26. 20.Tanaka T, Nakajima K, Murashima A, Garcia-Bournissen F, Koren G,Ito S. Safety of neuraminidase inhibitors against novel influenza A (H1N1)in pregnant and breastfeeding women. CMAJ. 2009;181:55-8

Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı ve Yenidoğan Bebeğe Etkileri

Year 2019, Volume: 11 Issue: 4, 205 - 212, 03.07.2019

Abstract

Öz

Anne sütü, hem bebek hem de anneye çok sayıda yararı olan eşsiz bir besindir. Bu kadar önemli bir besin kaynağı, bazen annenin çeşitli nedenlerle kullandığı ilaçların anne sütüne geçip bebeği olumsuz etkileyebileceği endişesi ile aileler tarafından, bazen de bu konuda bilinçli olmayan sağlık çalışanları tarafından gereksiz yere kesilebilmektedir. Oysa, ilaçların anne sütüne geçişini belirleyen birçok faktör bulunmaktadır ve çoğu ilacın da yenidoğan döneminde herhangi bir olumsuz etkisi rapor edilmemiştir. Bu yazıda emziren annelerde ilaç kullanımı ve bu ilaçların yenidoğan bebeklere etkileri gözden geçirilerek, sağlık çalışanlarının anne sütünün gereksiz yere kesilmemesi konusunda bilinçlendirilmesi amaçlanmıştır.

References

  • Kaynaklar 1.Lawrence RA, Lawrence RM. Breastfeeding: A Guide for the MedicalProfession. “Medications, Herbal Preparations, and Natural Productsin Breast Milk”. 8th Edition. Philadelphia, Elsevier, 2015:364-406. 2.Mcclary MD. Principles of Drug Use During Lactation. In: MartinRJ, Fanaroff AA, Walsh MC, eds, Fanaroff and Martin’s NeonatalPerinatal Medicine. 10th edition, Vol.2. Philadelphia: Saunders.2015;660-4. 3.Rowe H, Baker T, Hale TW. Maternal medication, drug use, and bre-astfeeding. Adolesc Psychiatr Clin N Am. 2015;24:1-20. 4.Anderson PO, Pochop SL, Manoguerra AS. Adverse drug reactionsin breastfed infants: less than imagined. Clin Pediatr (Phila).2003;42:325-40. 5.Passmore CM, McElnay JC, Rainey EA, et al. Metronidazole exc-retion in human milk and its effect on the suckling neonate. Br J ClinPharmacol. 1988;26:45–51. 6.Clark JH, Wilson WG. A 16-day-old breast-fed infant with metabolicacidosis caused by salicylate. Clin Pediatr (Phila). 1981;20:53-4. 7.Koren G, Cairns J, Chitayat D, et al. Pharmacogenetics of morphi-ne poisoning in a breastfed neonate of a codeine-prescribed mother.Lancet. 2006;368:704. 8.American Academy of Pediatrics Committee on Drugs. Transfer of drugsand other chemicals into human milk. Pediatrics. 2001;108:776-89. 9.Hudzik B, Zubelewicz-Szkodzinska B. Antithyroid drugs during bre-astfeeding. Clin Endocrinol (Oxf). 2016;85:827-30. 10.Prednisone. Drugs and Lactation Database (LactMed) [Internet]. Bet-hesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000136 11.Prednisolone. Drugs and Lactation Database (LactMed) [Internet].Bethesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000135 12.Methylprednisolone. Drugs and Lactation Database (LactMed)[Internet]. Bethesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000087 13.Dexamethasone. Drugs and Lactation Database (LactMed) [Inter-net]. Bethesda (MD): National Library of Medicine (US); 2006.https://www.ncbi.nlm.nih.gov/pubmed/30000826 14.Butler DC, Heller MM, Murase JE. Safety of dermatologic medica-tions in pregnancy and lactation: Part II. Lactation. J Am Acad Der-matol. 2014;70:417-27. 15.De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hyper-tension with mineralocorticoid excess in an infant. Helv Paediatr Acta.1983;38:185-9. 16.Stahl MM, Neiderud J, Vinge E. Thrombocytopenic purpura and ane-mia in a breast-fed infant whose mother was treated with valproicacid. J Pediatr. 1997;130:1001-3. 17.Frey B, Braegger CP, Ghelfi D. Neonatal cholestatic hepatitis fromcarbamazepine exposure during pregnancy and breast feeding. AnnPharmacother. 2002;36:644-7. 18.Kronenfeld N, Berlin M, Shaniv D, Berkovitch M. Use of Psychot-ropic Medications in Breastfeeding Women. Birth Defects Res.2017;109:957-97. 19.Spencer JP, Gonzalez LS 3rd, Barnhart DJ. Medications in the breast-feeding mother. Am Fam Physician. 2001;64:119-26. 20.Tanaka T, Nakajima K, Murashima A, Garcia-Bournissen F, Koren G,Ito S. Safety of neuraminidase inhibitors against novel influenza A (H1N1)in pregnant and breastfeeding women. CMAJ. 2009;181:55-8
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Details

Primary Language Turkish
Journal Section makale
Authors

Prof.dr. Mehmet Mutlu This is me

Publication Date July 3, 2019
Published in Issue Year 2019 Volume: 11 Issue: 4

Cite

APA Mutlu, P. M. (2019). Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı ve Yenidoğan Bebeğe Etkileri. Klinik Tıp Pediatri Dergisi, 11(4), 205-212.
AMA Mutlu PM. Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı ve Yenidoğan Bebeğe Etkileri. Pediatri. July 2019;11(4):205-212.
Chicago Mutlu, Prof.dr. Mehmet. “Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı Ve Yenidoğan Bebeğe Etkileri”. Klinik Tıp Pediatri Dergisi 11, no. 4 (July 2019): 205-12.
EndNote Mutlu PM (July 1, 2019) Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı ve Yenidoğan Bebeğe Etkileri. Klinik Tıp Pediatri Dergisi 11 4 205–212.
IEEE P. M. Mutlu, “Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı ve Yenidoğan Bebeğe Etkileri”, Pediatri, vol. 11, no. 4, pp. 205–212, 2019.
ISNAD Mutlu, Prof.dr. Mehmet. “Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı Ve Yenidoğan Bebeğe Etkileri”. Klinik Tıp Pediatri Dergisi 11/4 (July 2019), 205-212.
JAMA Mutlu PM. Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı ve Yenidoğan Bebeğe Etkileri. Pediatri. 2019;11:205–212.
MLA Mutlu, Prof.dr. Mehmet. “Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı Ve Yenidoğan Bebeğe Etkileri”. Klinik Tıp Pediatri Dergisi, vol. 11, no. 4, 2019, pp. 205-12.
Vancouver Mutlu PM. Yenidoğan Döneminde Emziren Annelerde İlaç Kullanımı ve Yenidoğan Bebeğe Etkileri. Pediatri. 2019;11(4):205-12.