Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı

Abdullah Bereket

Review

Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı

Year 2019, Volume: 11 Issue: 6, 298 - 306, 01.12.2019

Abdullah Bereket

Abstract

Obezite epidemisine paralel olarak tüm dünyada artış gösteren Tip-2 Diyabetes Mellitus
(Tip-2DM) olguları giderek daha erken yaşlara kaymaya başlamış ve artık adolesanlarda
da görülmeye başlamıştır. Adolesanlardaki Tip-2DM yi çocukluk çağında daha
sık görülen Tip-1DM den ve MODY den ayırmak hem klinik yaklaşım, hem prognoz
açısından önemlidir. Bu yazıda çocuk ve adolesanlarda T2DM in tanı ve tedavisi gözden
geçirlecektir.

Keywords

Diabetes Mellitus, Type-2 diabetes, insülin resistance

References

1. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005; 146:693.
2. Weiss R, Caprio S, Trombetta M, et al. Beta-cell function across the spectrum of glucose tolerance in obese youth. Diabetes 2005; 54:1735.
3. Elder DA, Hornung LN, Herbers PM, et al. Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes. J Pediatr 2015; 166:672.
4. Dabelea D, Mayer-Davis EJ, Saydah S, et al. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 2014; 311:1778.
5. Pinhas-Hamiel O, Dolan LM, Daniels SR, et al. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 1996; 128:608.
6. Writing Group for the SEARCH for Diabetes in Youth Study Group, Dabelea D, Bell RA, et al. Incidence of diabetes in youth in the United States. JAMA 2007; 297:2716.
7. Urakami T, Kubota S, Nitadori Y, et al. Annual incidence and clinical characteristics of type 2 diabetes in children as detected by urine glucose screening in the Tokyo metropolitan area. Diabetes Care 2005; 28:1876.
8. Likitmaskul S, Kiattisathavee P, Chaichanwatanakul K, et al. Increasing prevalence of type 2 diabetes mellitus in Thai children and adolescents associated with increasing prevalence of obesity. J Pediatr Endocrinol Metab 2003; 16:71.
9. United States Centers for Disease Control: National Diabetes Statistics Report, 2014. Available at: http://www.cdc.gov/diabetes /pubs/statsreport14.htm (Accessed on July 18, 2014).
10. Saygın Abalı, Enes Çelik, Belma Haliloğlu, Nuray Kırkıç, Serpil Baş, Zeynep Atay, Tülay Güran, Serap Turan, Abdullah Bereket. Çocukluk Çağı Diyabetinde Etiyoloji ve Demografik Özellikler: Marmara Deneyimi: Ulusal Pediatrik Endokrinoloji Kongresi İstanbul, 2014
11. Babaoglu K, Hatun S, Arslanoglu I, Isguven P, Bas F, Ercan O, Darendelile, F, Bundak R, Saka N, Gunoz H, Bereket A, Memioglu N, Neyzi O. Evaluation of glucose intolerance in adolescents relative to adults with type 2 diabetes mellitus. J Pediatr Endocrinol Metab. 2006 19(11):1319-26.
12. Lee JM, Okumura MJ, Freed GL, et al. Trends in hospitalizations for diabetes among children and young adults: United States, 1993 2004. Diabetes Care 2007; 30:3035.
13. Liu LL, Lawrence JM, Davis C, et al. Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth study. Pediatr Diabetes 2010; 11:4.
14. Copeland KC, Zeitler P, Geffner M, et al. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 2011; 96:159.
15. Freedman DS, Srinivasan SR, Burke GL, et al. Relation of body fat distribution to hyperinsulinemia in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr 1987; 46:403.
16. Meigs JB, Cupples LA, Wilson PW. Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes 2000; 49:2201.
17. Barnett AH, Eff C, Leslie RD, Pyke DA. Diabetes in identical twins. A study of 200 pairs. Diabetologia 1981; 20:87.
18. Voight BF, Scott LJ, Steinthorsdottir V, et al. .; MAGIC investigators; GIANT Consortium .. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579–589
19. Ball GD, Huang TT, Gower BA, et al. Longitudinal changes in insulin sensitivity, insulin secretion, and beta-cell function during puberty. J Pediatr 2006; 148:16.
20. Gungor N, Hannon T, Libman I, et al. Type 2 diabetes mellitus in youth: the complete picture to date. Pediatr Clin North Am 2005; 52:1579.
21. C Kurtoğlu S, Hatipoğlu N, Mazıcıoğlu M, Kendirici M, Keskin M, Kondolot M. Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol.2010;2(3):100-6
22. Forsén T, Eriksson J, Tuomilehto J, et al. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med 2000; 133:176.
23. Sapru A, Gitelman SE, Bhatia S, et al. Prevalence and characteristics of type 2 diabetes mellitus in 9-18 year-old children with diabetic ketoacidosis. J Pediatr Endocrinol Metab 2005; 18:865.
24. Rewers A, Klingensmith G, Davis C, et al. Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth Study. Pediatrics 2008; 121:e1258.
25. American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care 2017; 40:S11.
26. Shaw JE, Zimmet PZ, McCarty D, de Courten M. Type 2 diabetes worldwide according to the new classification and criteria. Diabetes Care 2000; 23 Suppl 2:B5.
27. International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009; 32:1327.
28. Kapadia C, Zeitler P, Drugs and Therapeutics Committee of the Pediatric Endocrine Society. Hemoglobin A1c measurement for the diagnosis of Type 2 diabetes in children. Int J Pediatr Endocrinol 2012; 2012:31.
29. Dabelea D, Pihoker C, Talton JW, et al. Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study. Diabetes Care 2011; 34:1628.
30. Klingensmith GJ, Pyle L, Arslanian S, et al. The presence of GAD and IA-2 antibodies in youth with a type 2 diabetes phenotype: results from the TODAY study. Diabetes Care 2010; 33:1970.
31. American Diabetes Association. 5. Prevention or Delay of Type 2 Diabetes. Diabetes Care 2017; 40:S44.
32. Libman IM, Barinas-Mitchell E, Bartucci A, et al. Reproducibility of the oral glucose tolerance test in overweight children. J Clin Endocrinol Metab 2008; 93:4231.
33. Quinn SM, Baur LA, Garnett SP, Cowell CT. Treatment of clinical insulin resistance in children: a systematic review. Obes Rev 2010; 11:722.
34. Willi SM, Martin K, Datko FM, Brant BP. Treatment of type 2 diabetes in childhood using a very-low-calorie diet. Diabetes Care 2004; 27:348.
35. Copeland KC, Silverstein J, Moore KR, et al. Management of newly diagnosed type 2 Diabetes Mellitus (T2DM) in children and adolescents. Pediatrics 2013; 131:364.
36. Springer SC, Silverstein J, Copeland K, et al. Management of type 2 diabetes mellitus in children and adolescents. Pediatrics 2013; 131:e648.
37. TODAY Study Group, Zeitler P, Epstein L, et al. Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative
efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes. Pediatr Diabetes 2007; 8:74.
38. TODAY Study Group, Zeitler P, Hirst K, et al. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 2012; 366:2247.
39. Kelly AS, Rudser KD, Nathan BM, et al. The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents
with severe obesity: a randomized, placebo-controlled, clinical trial. JAMA Pediatr 2013; 167:355.
40. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med 2015; 373:2117.
41. Hasan FM, Alsahli M, Gerich JE. SGLT2 inhibitors in the treatment of type 2 diabetes. Diabetes Res Clin Pract 2014; 104:297.
42. Tahrani AA, Barnett AH, Bailey CJ. SGLT inhibitors in management of diabetes. Lancet Diabetes Endocrinol 2013; 1:140.
43. Inge TH, Miyano G, Bean J, et al. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics 2009; 123:214.
44. Expert Panel on Blood Cholesterol Levels in Children and Adolescents: Treatment recommendations of the National Cholesterol Education Program report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatrics, 1992;89 (Suppl.):525-584.
45. HEALTHY Study Group, Foster GD, Linder B, et al. A school-based intervention for diabetes risk reduction. N Engl J Med 2010; 363:443.
46. Young TK, Martens PJ, Taback SP, Sellers EA, Dean HJ, Cheang M, Flett B. Type 2 diabetes mellitus in children: prenatal and early infancy risk factors among native Canadians. Arch Pediatr Adolesc Med 2002;156(7):651-5.
Bu Makale Klinik Tıp Bilimleri Dergisi’nin Cilt 5 Sayı 4 Nisan 2017 saysından alınarak tıpkısının aynısı olarak yayınlamıştıR.

Year 2019, Volume: 11 Issue: 6, 298 - 306, 01.12.2019

Abdullah Bereket

Abstract

References

1. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005; 146:693.
2. Weiss R, Caprio S, Trombetta M, et al. Beta-cell function across the spectrum of glucose tolerance in obese youth. Diabetes 2005; 54:1735.
3. Elder DA, Hornung LN, Herbers PM, et al. Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes. J Pediatr 2015; 166:672.
4. Dabelea D, Mayer-Davis EJ, Saydah S, et al. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 2014; 311:1778.
5. Pinhas-Hamiel O, Dolan LM, Daniels SR, et al. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 1996; 128:608.
6. Writing Group for the SEARCH for Diabetes in Youth Study Group, Dabelea D, Bell RA, et al. Incidence of diabetes in youth in the United States. JAMA 2007; 297:2716.
7. Urakami T, Kubota S, Nitadori Y, et al. Annual incidence and clinical characteristics of type 2 diabetes in children as detected by urine glucose screening in the Tokyo metropolitan area. Diabetes Care 2005; 28:1876.
8. Likitmaskul S, Kiattisathavee P, Chaichanwatanakul K, et al. Increasing prevalence of type 2 diabetes mellitus in Thai children and adolescents associated with increasing prevalence of obesity. J Pediatr Endocrinol Metab 2003; 16:71.
9. United States Centers for Disease Control: National Diabetes Statistics Report, 2014. Available at: http://www.cdc.gov/diabetes /pubs/statsreport14.htm (Accessed on July 18, 2014).
10. Saygın Abalı, Enes Çelik, Belma Haliloğlu, Nuray Kırkıç, Serpil Baş, Zeynep Atay, Tülay Güran, Serap Turan, Abdullah Bereket. Çocukluk Çağı Diyabetinde Etiyoloji ve Demografik Özellikler: Marmara Deneyimi: Ulusal Pediatrik Endokrinoloji Kongresi İstanbul, 2014
11. Babaoglu K, Hatun S, Arslanoglu I, Isguven P, Bas F, Ercan O, Darendelile, F, Bundak R, Saka N, Gunoz H, Bereket A, Memioglu N, Neyzi O. Evaluation of glucose intolerance in adolescents relative to adults with type 2 diabetes mellitus. J Pediatr Endocrinol Metab. 2006 19(11):1319-26.
12. Lee JM, Okumura MJ, Freed GL, et al. Trends in hospitalizations for diabetes among children and young adults: United States, 1993 2004. Diabetes Care 2007; 30:3035.
13. Liu LL, Lawrence JM, Davis C, et al. Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth study. Pediatr Diabetes 2010; 11:4.
14. Copeland KC, Zeitler P, Geffner M, et al. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 2011; 96:159.
15. Freedman DS, Srinivasan SR, Burke GL, et al. Relation of body fat distribution to hyperinsulinemia in children and adolescents: the Bogalusa Heart Study. Am J Clin Nutr 1987; 46:403.
16. Meigs JB, Cupples LA, Wilson PW. Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes 2000; 49:2201.
17. Barnett AH, Eff C, Leslie RD, Pyke DA. Diabetes in identical twins. A study of 200 pairs. Diabetologia 1981; 20:87.
18. Voight BF, Scott LJ, Steinthorsdottir V, et al. .; MAGIC investigators; GIANT Consortium .. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579–589
19. Ball GD, Huang TT, Gower BA, et al. Longitudinal changes in insulin sensitivity, insulin secretion, and beta-cell function during puberty. J Pediatr 2006; 148:16.
20. Gungor N, Hannon T, Libman I, et al. Type 2 diabetes mellitus in youth: the complete picture to date. Pediatr Clin North Am 2005; 52:1579.
21. C Kurtoğlu S, Hatipoğlu N, Mazıcıoğlu M, Kendirici M, Keskin M, Kondolot M. Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Pediatr Endocrinol.2010;2(3):100-6
22. Forsén T, Eriksson J, Tuomilehto J, et al. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med 2000; 133:176.
23. Sapru A, Gitelman SE, Bhatia S, et al. Prevalence and characteristics of type 2 diabetes mellitus in 9-18 year-old children with diabetic ketoacidosis. J Pediatr Endocrinol Metab 2005; 18:865.
24. Rewers A, Klingensmith G, Davis C, et al. Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth Study. Pediatrics 2008; 121:e1258.
25. American Diabetes Association. 2. Classification and Diagnosis of Diabetes. Diabetes Care 2017; 40:S11.
26. Shaw JE, Zimmet PZ, McCarty D, de Courten M. Type 2 diabetes worldwide according to the new classification and criteria. Diabetes Care 2000; 23 Suppl 2:B5.
27. International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009; 32:1327.
28. Kapadia C, Zeitler P, Drugs and Therapeutics Committee of the Pediatric Endocrine Society. Hemoglobin A1c measurement for the diagnosis of Type 2 diabetes in children. Int J Pediatr Endocrinol 2012; 2012:31.
29. Dabelea D, Pihoker C, Talton JW, et al. Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study. Diabetes Care 2011; 34:1628.
30. Klingensmith GJ, Pyle L, Arslanian S, et al. The presence of GAD and IA-2 antibodies in youth with a type 2 diabetes phenotype: results from the TODAY study. Diabetes Care 2010; 33:1970.
31. American Diabetes Association. 5. Prevention or Delay of Type 2 Diabetes. Diabetes Care 2017; 40:S44.
32. Libman IM, Barinas-Mitchell E, Bartucci A, et al. Reproducibility of the oral glucose tolerance test in overweight children. J Clin Endocrinol Metab 2008; 93:4231.
33. Quinn SM, Baur LA, Garnett SP, Cowell CT. Treatment of clinical insulin resistance in children: a systematic review. Obes Rev 2010; 11:722.
34. Willi SM, Martin K, Datko FM, Brant BP. Treatment of type 2 diabetes in childhood using a very-low-calorie diet. Diabetes Care 2004; 27:348.
35. Copeland KC, Silverstein J, Moore KR, et al. Management of newly diagnosed type 2 Diabetes Mellitus (T2DM) in children and adolescents. Pediatrics 2013; 131:364.
36. Springer SC, Silverstein J, Copeland K, et al. Management of type 2 diabetes mellitus in children and adolescents. Pediatrics 2013; 131:e648.
37. TODAY Study Group, Zeitler P, Epstein L, et al. Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative
efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes. Pediatr Diabetes 2007; 8:74.
38. TODAY Study Group, Zeitler P, Hirst K, et al. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med 2012; 366:2247.
39. Kelly AS, Rudser KD, Nathan BM, et al. The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents
with severe obesity: a randomized, placebo-controlled, clinical trial. JAMA Pediatr 2013; 167:355.
40. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med 2015; 373:2117.
41. Hasan FM, Alsahli M, Gerich JE. SGLT2 inhibitors in the treatment of type 2 diabetes. Diabetes Res Clin Pract 2014; 104:297.
42. Tahrani AA, Barnett AH, Bailey CJ. SGLT inhibitors in management of diabetes. Lancet Diabetes Endocrinol 2013; 1:140.
43. Inge TH, Miyano G, Bean J, et al. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics 2009; 123:214.
44. Expert Panel on Blood Cholesterol Levels in Children and Adolescents: Treatment recommendations of the National Cholesterol Education Program report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatrics, 1992;89 (Suppl.):525-584.
45. HEALTHY Study Group, Foster GD, Linder B, et al. A school-based intervention for diabetes risk reduction. N Engl J Med 2010; 363:443.
46. Young TK, Martens PJ, Taback SP, Sellers EA, Dean HJ, Cheang M, Flett B. Type 2 diabetes mellitus in children: prenatal and early infancy risk factors among native Canadians. Arch Pediatr Adolesc Med 2002;156(7):651-5.
Bu Makale Klinik Tıp Bilimleri Dergisi’nin Cilt 5 Sayı 4 Nisan 2017 saysından alınarak tıpkısının aynısı olarak yayınlamıştıR.

There are 49 citations in total.

Details

Primary Language	Turkish
Subjects	Internal Diseases
Journal Section	makale
Authors	Abdullah Bereket This is me
Publication Date	December 1, 2019
Published in Issue	Year 2019 Volume: 11 Issue: 6

Cite

APA	Bereket, A. (2019). Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı. Klinik Tıp Pediatri Dergisi, 11(6), 298-306.
AMA	Bereket A. Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı. Pediatri. December 2019;11(6):298-306.
Chicago	Bereket, Abdullah. “Çocuk Ve Adesolesanlarda Tip-2 Diyabetin Tanısı”. Klinik Tıp Pediatri Dergisi 11, no. 6 (December 2019): 298-306.
EndNote	Bereket A (December 1, 2019) Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı. Klinik Tıp Pediatri Dergisi 11 6 298–306.
IEEE	A. Bereket, “Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı”, Pediatri, vol. 11, no. 6, pp. 298–306, 2019.
ISNAD	Bereket, Abdullah. “Çocuk Ve Adesolesanlarda Tip-2 Diyabetin Tanısı”. Klinik Tıp Pediatri Dergisi 11/6 (December 2019), 298-306.
JAMA	Bereket A. Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı. Pediatri. 2019;11:298–306.
MLA	Bereket, Abdullah. “Çocuk Ve Adesolesanlarda Tip-2 Diyabetin Tanısı”. Klinik Tıp Pediatri Dergisi, vol. 11, no. 6, 2019, pp. 298-06.
Vancouver	Bereket A. Çocuk ve Adesolesanlarda Tip-2 Diyabetin Tanısı. Pediatri. 2019;11(6):298-306.

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