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Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?

Year 2020, Volume: 12 Issue: 2, 54 - 56, 01.04.2020

Metin Aydoğan

Abstract

Gıda proteinine bağlı gelişen alerjik proktokolit (AP), tipik olarak bebeklik döneminde
ortaya çıkan, anne sütü alan bebeklerde sık görülen ve sıklıkla gastrointestinal
sistemi etkileyen immünoglobulin E (IgE) aracılı olmayan gıda alerjileridir. Farklı sosyokültürel
özellikleri ve beslenme alışkanlıkları olan ülkelerde hastalığın sıklığı ve prognozu
da farklı olabilmektedir. Ülkemizde ve birçok ülkede de gıda alerjisi yaygınlığı
özellikle pediatri popülasyonunda giderek artmakta ve önemli bir halk sağlığı sorunu
haline gelmektedir. AP sağlıklı bir bebeklerde mukuslu, köpüklü ve kanlı dışkı varlığı
ile karakterize şeklinde tanımlanır. Ancak, AP’Lİ bebeklerde kanlı kaka, mukuslu
kaka en sık görülen semptomlar olmakla birlikte atopik dermatit (bebeklerin % 38'inde
başvuru sırasında veya takip sırasında atopik dermatit eşlik edebilir), ishal, kolik,
kusma, besin reddi, tartı alımında duraklama, geçmeyen peri-anal kızarıklık, geçmeyen
pişik gibi diğer non-IgE ve miks grup aracılı bulguların da bir veya birden fazlası
bir arada olabilir. AP’li bebeklerde inek sütü protein alerjisi en yaygın olanıdır, ikinci
sırada yumurta, daha nadir olarak soya, dana eti, buğday, çerez bildirilmiştir. Spesifik
tanısal testler yoktur. Alerjik proktokolitin tanısı eliminasyon ve gıda yükleme ile
konulmaktadır. AP bebeklerde temel tedavi gıda eliminasyonudur. AP'de, annenin ve/veya
bebeğin beslenmesinden sorumlu gıdanın eliminasyonu genellikle yeterlidir. Çocuk inek
sütü bazlı formüla alıyorsa ve inek sütü alerjisi tespit edildi ise bu bebeklerin formülaları
yoğun hidrolize veya aminoasit formülalar ile değiştirilmelidir.

Keywords

alerjik proktokolit çocuk besin alerjileri

References

  • 1. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, et al. Guidelines for the diagnosis and management of food
  • allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutr Res. 2011;31(1):61-75.
  • 2. Odze RD, Bines J, Leichtner AM, Goldman H, Antonioli DA. Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study. Hum Pathol 1993;24: 668 – 674.
  • 3. Meyer R, Fleming C, Dominguez-Ortega G, Lindley K, Michaelis L, Thapar N, et al. Manifestations of food protein induced
  • gastrointestinal allergies presenting to a single tertiary pediatric gastroenterology unit. World Allergy Organ J 2013; 6:13.
  • 4. Elizur A, Cohen M, Goldberg MR, Rajuan N, Cohen A, Leshno M, et al. Cow’s milk associated rectal bleeding: A population
  • based prospective study. Pediatr Allergy Immunol 23:766–770, 2012.
  • 5. Morita H, Nomura I, Matsuda A, Saito H, Matsumoto K. Gastrointestinal food allergy in infants. Allergol Int 2013;62:297–307.
  • 6. Lack G. Update on risk factors for food allergy. J Allergy Clin Immunolog 2012;129:1187–97.
  • 7. Toporovski MS. Pediatricians and nutritionists knowledge about treatment of cow milk allergy in infants. Rev Paul Ped. 2007;25:104-5.
  • 8. Meyer R. New guidelines for managing cow’s milk allergy in infants. J Fam Health Care. 2008;18:27-30.
  • 9. Caubet J-C, Szajewska H, Shamir R, Nowak-Wezgrzyn A. Non- IgE-mediated gastrointestinal food allergies in children. Pediatr Allergy Immunol 2017: 28: 6–17.
  • 10. Naspitz CK, Solé D, Jacob CA, Sarinho E, Soares FJ, Dantas V, et al. Sensibiliza ̧cão a alérgicos inalantes e alimentares
  • em crian ̧cas brasileiras atópicas, pela determina ̧cão in vitro de IgE total e específica. Projeto Alergia (PROAL). J Pediatr (Rio J). 2004;80:203-10.
  • 11. Odze RD, Bines J, Leichtner AM, Goldman H, Antonioli DA. Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study. Hum Pathol 1993: 24: 668–74.
  • 12. Meyer R. New guidelines for managing cow’s milk allergy in infants. J Fam Health Care. 2008;18:27-30.
  • 13. Lozinsky AC, Morais MB. Eosinophilic colitis in infants. J Pediatr (Rio J). 2014;90(1):16-21.
  • 14. Kaya A, Toyran M, Civelek E, Misirlioglu E, Kirsaclioglu C, Kocabas CN. Characteristics and Prognosis of Allergic
  • Proctocolitis in Infants. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):69-73.
  • 15. Nacaroglu HT, Bahceci Erdem S, Durgun E, Karaman S, Baris Erdur C, Unsal Karkmer CS, et al. Markers of inflammation
  • and tolerance development in allergic proctocolitis. Arch Argent Pediatr. 2018 Feb 1;116(1):e1-e7.
  • 16. Arik Yilmaz E, Soyer O, Cavkaytar O, Karaatmaca B, Buyuktiryaki B, Sahiner UM, et al. Characteristics of children with
  • food protein-induced enterocolitis and allergic proctocolitis. Allergy Asthma Proc. 2017;38(1):54-62.
  • 17. Koksal BT, Barıs Z, Ozcay F, Yilmaz Ozbek O. Single and multiple food allergies in infants with proctocolitis. Allergol Immunopathol (Madr). 2018;46(1):3-8)
  • 18. Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015;135(5):1114–24.
  • 19. Boné J, Claver A, Guallar I, Plaza AM. Allergic proctocolitis, food-induced enterocolitis: immune mechanisms, diagnosis
  • and treatment. Allergol Immunopathol (Madr) 2009; 37:36–42.
  • 20. Maloney J, Nowak-Wegrzyn A. Educational clinical case series for pediatric allergy and immunology: allergic proctocolitis,
  • food protein-induced enterocolitis syndrome and allergic eosino- philic gastroenteritis with protein-losing gastroenteropathy
  • as man- ifestations of non-IgE-mediated cow’s milk allergy. Pediatr Allergy Immunol 2007;18:360–367
  • 21. Nowak-Wegrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol 2015: 135: 1114–24.
  • 22. Fernandes BN, Boyle RJ, Gore C, Simpson A, Custovic A. Food protein-induced enterocolitis syndrome can occur in adults. J Allergy Clin Immunol 2012: 130: 1199– 200.
  • 23. Nowak-Węgrzyn A. Food protein-induced enterocolitis syndrome and allergic proctocolitis. Allergy Asthma Proc. 2015;36(3):172–84.
  • 24. Luyt D, Ball H, Makwana N, Green MR, Bravin K, Nasser SM, et al. Standards of Care Committee (SOCC) of the British Society
  • for Allergy and Clinical Immunology (BSACI). BSACI guideline for the diagnosis and management of cow's milk allergy. Clin Exp Allergy. 2014;44(5):642-72.

Year 2020, Volume: 12 Issue: 2, 54 - 56, 01.04.2020

Metin Aydoğan

Abstract

References

  • 1. Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, et al. Guidelines for the diagnosis and management of food
  • allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutr Res. 2011;31(1):61-75.
  • 2. Odze RD, Bines J, Leichtner AM, Goldman H, Antonioli DA. Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study. Hum Pathol 1993;24: 668 – 674.
  • 3. Meyer R, Fleming C, Dominguez-Ortega G, Lindley K, Michaelis L, Thapar N, et al. Manifestations of food protein induced
  • gastrointestinal allergies presenting to a single tertiary pediatric gastroenterology unit. World Allergy Organ J 2013; 6:13.
  • 4. Elizur A, Cohen M, Goldberg MR, Rajuan N, Cohen A, Leshno M, et al. Cow’s milk associated rectal bleeding: A population
  • based prospective study. Pediatr Allergy Immunol 23:766–770, 2012.
  • 5. Morita H, Nomura I, Matsuda A, Saito H, Matsumoto K. Gastrointestinal food allergy in infants. Allergol Int 2013;62:297–307.
  • 6. Lack G. Update on risk factors for food allergy. J Allergy Clin Immunolog 2012;129:1187–97.
  • 7. Toporovski MS. Pediatricians and nutritionists knowledge about treatment of cow milk allergy in infants. Rev Paul Ped. 2007;25:104-5.
  • 8. Meyer R. New guidelines for managing cow’s milk allergy in infants. J Fam Health Care. 2008;18:27-30.
  • 9. Caubet J-C, Szajewska H, Shamir R, Nowak-Wezgrzyn A. Non- IgE-mediated gastrointestinal food allergies in children. Pediatr Allergy Immunol 2017: 28: 6–17.
  • 10. Naspitz CK, Solé D, Jacob CA, Sarinho E, Soares FJ, Dantas V, et al. Sensibiliza ̧cão a alérgicos inalantes e alimentares
  • em crian ̧cas brasileiras atópicas, pela determina ̧cão in vitro de IgE total e específica. Projeto Alergia (PROAL). J Pediatr (Rio J). 2004;80:203-10.
  • 11. Odze RD, Bines J, Leichtner AM, Goldman H, Antonioli DA. Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study. Hum Pathol 1993: 24: 668–74.
  • 12. Meyer R. New guidelines for managing cow’s milk allergy in infants. J Fam Health Care. 2008;18:27-30.
  • 13. Lozinsky AC, Morais MB. Eosinophilic colitis in infants. J Pediatr (Rio J). 2014;90(1):16-21.
  • 14. Kaya A, Toyran M, Civelek E, Misirlioglu E, Kirsaclioglu C, Kocabas CN. Characteristics and Prognosis of Allergic
  • Proctocolitis in Infants. J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):69-73.
  • 15. Nacaroglu HT, Bahceci Erdem S, Durgun E, Karaman S, Baris Erdur C, Unsal Karkmer CS, et al. Markers of inflammation
  • and tolerance development in allergic proctocolitis. Arch Argent Pediatr. 2018 Feb 1;116(1):e1-e7.
  • 16. Arik Yilmaz E, Soyer O, Cavkaytar O, Karaatmaca B, Buyuktiryaki B, Sahiner UM, et al. Characteristics of children with
  • food protein-induced enterocolitis and allergic proctocolitis. Allergy Asthma Proc. 2017;38(1):54-62.
  • 17. Koksal BT, Barıs Z, Ozcay F, Yilmaz Ozbek O. Single and multiple food allergies in infants with proctocolitis. Allergol Immunopathol (Madr). 2018;46(1):3-8)
  • 18. Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015;135(5):1114–24.
  • 19. Boné J, Claver A, Guallar I, Plaza AM. Allergic proctocolitis, food-induced enterocolitis: immune mechanisms, diagnosis
  • and treatment. Allergol Immunopathol (Madr) 2009; 37:36–42.
  • 20. Maloney J, Nowak-Wegrzyn A. Educational clinical case series for pediatric allergy and immunology: allergic proctocolitis,
  • food protein-induced enterocolitis syndrome and allergic eosino- philic gastroenteritis with protein-losing gastroenteropathy
  • as man- ifestations of non-IgE-mediated cow’s milk allergy. Pediatr Allergy Immunol 2007;18:360–367
  • 21. Nowak-Wegrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol 2015: 135: 1114–24.
  • 22. Fernandes BN, Boyle RJ, Gore C, Simpson A, Custovic A. Food protein-induced enterocolitis syndrome can occur in adults. J Allergy Clin Immunol 2012: 130: 1199– 200.
  • 23. Nowak-Węgrzyn A. Food protein-induced enterocolitis syndrome and allergic proctocolitis. Allergy Asthma Proc. 2015;36(3):172–84.
  • 24. Luyt D, Ball H, Makwana N, Green MR, Bravin K, Nasser SM, et al. Standards of Care Committee (SOCC) of the British Society
  • for Allergy and Clinical Immunology (BSACI). BSACI guideline for the diagnosis and management of cow's milk allergy. Clin Exp Allergy. 2014;44(5):642-72.
There are 35 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section makale
Authors

Metin Aydoğan This is me

Publication Date April 1, 2020
Published in Issue Year 2020 Volume: 12 Issue: 2

Cite

APA Aydoğan, M. (2020). Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?. Klinik Tıp Pediatri Dergisi, 12(2), 54-56.
AMA Aydoğan M. Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?. Pediatri. April 2020;12(2):54-56.
Chicago Aydoğan, Metin. “Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?”. Klinik Tıp Pediatri Dergisi 12, no. 2 (April 2020): 54-56.
EndNote Aydoğan M (April 1, 2020) Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?. Klinik Tıp Pediatri Dergisi 12 2 54–56.
IEEE M. Aydoğan, “Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?”, Pediatri, vol. 12, no. 2, pp. 54–56, 2020.
ISNAD Aydoğan, Metin. “Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?”. Klinik Tıp Pediatri Dergisi 12/2 (April 2020), 54-56.
JAMA Aydoğan M. Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?. Pediatri. 2020;12:54–56.
MLA Aydoğan, Metin. “Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?”. Klinik Tıp Pediatri Dergisi, vol. 12, no. 2, 2020, pp. 54-56.
Vancouver Aydoğan M. Çocuklarda Alerjik Proktokolit’i Nasıl Yönetelim?. Pediatri. 2020;12(2):54-6.
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