Depresyon ve Koku Bölgeleri Hacmi Arasındaki İlişkinin Parselasyon Yöntemiyle Değerlendirilmesi

Abstract

Major depresif bozukluğu bulunan bireylerde koku kaybının görüldüğü ve bulbus olfactorius hacminde küçülme meydana geldiği, literatürde yer alan bilimsel araştırmalarla ortaya konmuştur. Bu çalışmada, majör depresif bozukluk ile koku bölgelerinin hacmi arasındaki korelasyonun değerlendirilmesi amaçlanmaktadır. Çalışmada, Balıkesir Üniversitesi Eğitim ve Araştırma Hastanesi Ruh Sağlığı ve Hastalıkları Polikliniği'nde majör depresif bozukluk tanısı konulan 33 hasta ve kontrol grubunu oluşturacak 33 sağlıklı bireyin Manyetik Rezonans Görüntüleme (MRG) görüntüleri retrospektif olarak incelendi. Elde edilen MRG serilerinde koku duyusunda rol alan amygdala, gyrus fusiformis, commissura anterior, radiatio olfactoria ve entorhinal alan hacmi parselasyon yöntemi kullanılarak ölçüldü. Tüm veriler SPSS yazılımına aktarılarak kantitatif olarak analiz edildi. Araştırmada incelenen değişkenlerin istatistiksel analiz sonuçlarına göre, sağ-sol amigdalaların hasta bireylerde daha küçük hacme sahip olma eğilimi gösterdiği tespit edildi. Çalışmada değerlendirilen parametrelerden, sol amigdala, sol entorhinal alan ve sağ-sol fusiform gyrus hacimleri ile Hamilton Depresyon Ölçeği skalası arasında pozitif bir korelasyon olduğu görüldü.  Yapılan araştırmalar neticesinde, majör depresif bozukluk ile koku bölgeleri arasında negatif bir ilişki bulunduğu morfometrik analizler doğrultusunda ortaya konmuştur. Bu veriler ışığında elde edilen verilerin depresyon ve koku kaybı arasındaki neden-sonuç ilişkisinin anlaşılmasına katkıda bulunacağı, klinisyenler açısından ise tanı ve tedavide yol gösterici nitelikte olabileceği düşünülmektedir.

Keywords

• Major depresyon
• koku
• MRG
• parselasyon

Evaluation of the Relationship between Depression and the Volume of Olfactory Regions by Parcellation Method

Abstract

Scientific studies in the literature have demonstrated olfactory loss and reduced olfactory bulb volume in individuals with major depressive disorder. This study aims to evaluate the correlation between major depressive disorder and olfactory region volume. In the study, Magnetic Resonance İmaging (MRI) images of 33 patients with major depressive disorder and 33 healthy controls from Balıkesir University Hospital's Mental Health Clinic were retrospectively analyzed. In the obtained MRI series, the volumes of the amygdala, fusiform gyrus, anterior commissure, olfactory radiation, and entorhinal area, which are involved in olfaction, were measured using a parcellation method. All data were transferred to SPSS and analyzed quantitatively. The statistical analysis of the variables examined in the study revealed that the right and left amygdalae tend to be smaller in individuals with illness. It was determined that there was a positive correlation among the parameters evaluated in the study: left amygdala, left entorhinal area, right and left fusiform gyrus volumes, and the Hamilton Depression Scale. As a result of the research, it was revealed in the direction of morphometric analysis that there is a negative relationship between major depressive disorder and olfactory regions. The data obtained in light of these findings will contribute to understanding the cause-and-effect relationship between depression and loss of smell; for clinicians, it is expected to serve as a guide in diagnosis and treatment.

Keywords

• Major depression
• olfaction
• MRI
• parcellation

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