Saklı Ada: Insula

Year 2019, , 57 - 63, 30.04.2019

Sevda Lafcı Fahrioğlu Sezgin İlgi

https://doi.org/10.35365/ctjpp.19.1.07

Abstract

Bu derleme yazısında insula’nın gros ve mikroskobik anatomisi, fizyolojik bağlantıları ve fonksiyonları ile
çeşitli nörolojik ve psikiyatrik hastalıklardaki rolü hakkında bilgi verilmesi amaçlanmıştır. Beynin eksternal
yüzünden bakıldığında görülemeyen, ancak sulcus lateralisaralandığında görünür hale gelebilen, korikal bir saha
olan insula, son 25-30 yılda fonksiyonlarınınanlaşılmaya başlanması ve bazı nörolojik ve psikiyatrik hastalıkların
mekanizmasındaki rolünün tartışılabilir hale gelmesiyle nöro-görüntüleme çalışmalarının da ilgi odağı olmuştur.
Insula’nın olfaktor saha, corpus amygdaloideum, entorhinal saha, gyrus cinguli ve hippocampus ile olan bağlantıları
limbik sistem ile birlikte önemli fonksiyonları olduğunun önemli kanıtlarındandır. Bu gereksinim ışığında,insula
hakkında literatürde yer alan bilgiler bir araya getirilmiştir. Limbik integrasyon ile visseral ve otonomik
fonksiyonlardaki önemi sayesinde insula, demanstan şizofreniye kadar geniş bir yelpazede yer alan nöropsikiyatrik
hastalıkların patomekanizmasında halen açıklığa kavuşturulmayı bekleyen birçok gizemi barındırmaktadır. 

Keywords

insula, insular kortex, von economo nöronları, bilişsel fonksiyon, limbik sistem

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