Levamizol Uygulanmasının Şarbon Hastalığına Karşı Aşılanmış Sığırlarda Bağışıklık Sistemi Üzerine Etkileri

Abstract

Bu araştırmada şarbon hastalığına karşı aşılanan sığırlarda levamizol uygulamasının bağışıklık sistemi üzerine olan etkisi araştırıldı. Araştırmada toplam 40 adet sağlıklı sığır kullanıldı. Sığırlar dört eşit gruba ayrıldı. Kontrol grubuna üçer gün arayla ve bir dozu da 10. gün olmak üzere plasebo olarak serum fizyolojik dört defa deri altına enjekte edildi. İkinci gruba (aşı grubu) üçer gün arayla üç kez serum fizyolojik sonrası 10. gün şarbon aşısı deri altı, üçüncü gruba (aşı-levamizol) üçer gün arayla üç kez levamizol çözeltisinden 2,5 mg/kg dozda deri altı ve sonrası 10. gün şarbon aşısı deri altı, dördüncü gruba (levamizol) ise üçer gün arayla üç defa levamizol 2,5 mg/kg dozda deri altı ve sonrası 10. günde serum fizyolojik deri altına enjekte edildi. Aşılama sonrası aşı-levamizol grubunda nötrofil, lenfosit, monosit ve serum İgG miktarının sadece aşı uygulanan gruba göre anlamlı düzeyde (p<0,05) arttığı görüldü. Sığırlara şarbon aşısı uygulanmadan önce üçer gün ara ile üç kez 2,5 mg/kg dozda deri altı verilen levamizolün bağışıklık sistemi üzerine uyarıcı etki gösterdiği sonucuna varıldı.

Keywords

• Sığır
• şarbon aşısı
• levamizol
• bağışıklık sistemi

Project Number

2020-003

Effects of Levamisole Application on Immunity System in Anthrax-Vaccinated Cattle

Abstract

The present study investigated the effect of levamisole administration on the immune system of anthrax-vaccinated cattle. Totally, 40 healthy cattle were employed in the study. Cattle were divided into 4 even groups. In the control group, saline was subcutaneously injected four times as a placebo, every three days, and one dose was administered on the 10th day. In the second group (vaccine group), anthrax vaccine was administered subcutaneously on the 10th day following the administration of physiological saline three times every three days. The 3rd group (vaccine-levamisole) was subcutaneously administered levamisole at a dose of 2.5 mg/kg three times with three-day intervals and on the following 10th day, anthrax vaccine was administered. The 4th group (levamisole) was subcutaneously administered levamisole at a dose of 2.5 mg/kg three times with three-day intervals and physiological saline was subcutaneously injected on the following 10th day. After vaccination neutrophils, lymphocytes, monocytes count, and the serum IgG amount of the vaccine-levamisole group were found to increase significantly (p<0.05) compared to the vaccine-only group. It was concluded that subcutaneously administered levamisole at a dose of 2.5 mg/kg three times with three-day intervals before administrating the anthrax vaccine to cattle, had a stimulating effect on the immune system.

Keywords

• Cattle
• anthrax vaccine
• levamisole
• immune system

Supporting Institution

University of Ardahan

Project Number

2020-003

Thanks

I would like to thank Ardahan University Scientific Research Projects Coordinatorship.

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