Correlations Between Venous Acid-Base Status and Renal Function in Neonatal Calves with Acute Diarrhea

Abstract

In the present study, the relationship between venous acid-base status and renal function was investigated. 50 calves with acute diarrhea and clinically healthy 6 totally 56 calves of diverse breed and sex aged between 1-30 days were used. Each of these calves urea, creatine, potassium, albumine, cholestrol, triglycerides, high density lipoprotein, creatine kinase, creatine kinase-MB, total biluribin, glucose, alanine amino transferase, aspartate amino transferase, gamma-glutamil transferase, phosphorus, calcium, sodium, bicarbonate and pH were measured in the blood serum and correlation between the parameters were calculated. As a result pH, bicarbonate, potassium, urea, creatinine, triglycerides, high density lipoprotein, phosphorus and creatine kinase-MB values significantly different in the calves with acute diarrhea compare with the control group. For albumine, cholestrol, creatine kinase, total biluribin, glucose, alanin amino transferase, aspartat amino transferase, gamma glutamil transferase, calcium and sodium values were not changed significanty in the groups. Otherwise, negative correlation were calculated between renal functions with pH and bicarbonate. Our data show that as well as metabolic acidosis, renal disfunction and changes in metabolic (hypophosphotemia, hypolipidemia, etc) should be considered determination of treatment procedure and detection of prognosis in the neonatal calves with acute diarrhea

Keywords

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Akut İshalli Neonatal Buzağılarda Venöz Asit-Baz Durumu ve Renal Fonksiyon Arası Korelasyon

Öz

Sunulan çalışmada akut ishalli neonatal buzağılarda venöz asit-baz durumu ve renal fonksiyon arası ilişki irdelenmiştir. Çalışma materyalini, yaşları 1-30 gün arasında değişen, farklı ırk ve cinsiyette akut ishalli 50 ve klinik olarak sağlıklı 6, toplam 56 neonatal buzağı oluşturdu. Materyali oluşturan buzağıların kanlarında; üre, kreatinin, potasyum, albumin, kolesterol, trigliserid, yüksek dansiteli lipoprotein, kreatin kinaz, kreatin kinaz-MB, total biluribin, glukoz, alanin amino transferaz, aspartat amino transferaz, gamma glutamil transferaz, fosfor, kalsiyum, sodyum, bikarbonat ve pH değerleri ölçüldü ve ölçülen parametreler arası korelasyon hesaplandı. Çalışma sonuçları; ishalli buzağılarda, kontrol grubuna göre; pH, bikarbonat, potasyum, üre, kreatinin, trigliserit, yüksek dansiteli lipoprotein, fosfor ve kreatinkinaz-MB değerlerinde istatistiksel olarak önemli derecede bir farkın olduğunu ortaya koydu. Albumin, kolestrol, kreatin kinaz, total biluribin, glukoz, alanin amino transferaz, aspartat amino transferaz, gamma glutamil transferaz, kalsiyum ve sodyum değerlerinde ise istatistiksel olarak bir fark tespit edilmedi. Renal fonksiyon ile kan pH ve bikarbonat değerleri arasında negatif korelasyon belirlendi. Elde edilen veriler, akut ishalli neonatal buzağılarda tedavi prosedürünün tayini ve prognozun tespitinde, metabolik asidozisin yanısıra, renal fonksiyondaki bozulma ve metabolik durum değişikliklerinin de (hipofosfatemi, hipokolestrolemi vb) göz önünde bulundurulması gerektiğine vurgu yapmaktadır. ●●● Correlations Between Venous Acid-Base Status and Renal Function in Neonatal Calves With Acute Diarrhea S U M M A R Y In the present study, the relationship between venous acid-base status and renal function was investigated. 50 calves with acute diarrhea and clinically healthy 6 totally 56 calves of diverse breed and sex aged between 1-30 days were used. Each of these calves urea, creatine, potassium, albumine, cholestrol, triglycerides, high density lipoprotein, creatine kinase, creatine kinase-MB, total biluribin, glucose, alanine amino transferase, aspartate amino transferase, gamma-glutamil transferase, phosphorus, calcium, sodium, bicarbonate and pH were measured in the blood serum and correlation between the parameters were calculated. As a result pH, bicarbonate, potassium, urea, creatinine, triglycerides, high density lipoprotein, phosphorus and creatine kinase-MB values significantly different in the calves with acute diarrhea compare with the control group. For albumine, cholestrol, creatine kinase, total biluribin, glucose, alanin amino transferase, aspartat amino transferase, gamma glutamil transferase, calcium and sodium values were not changed significanty in the groups. Otherwise, negative correlation were calculated between renal functions with pH and bicarbonate. Our data show that as well as metabolic acidosis, renal disfunction and changes in metabolic (hypophosphotemia, hypolipidemia, etc) should be considered determination of treatment procedure and detection of prognosis in the neonatal calves with acute diarrhea.

Anahtar Kelimeler

• Acidemia CK-MB Dehydration

References

1. Aldridge BM, Garry FB, Adams R. 1993. Neonatal septicemia in calves: 25 cases (19851990). JAVMA, 203 (9):1324-1330.
2. Aslan V. 1994. Neonatal ishaller. Mimoza yayınları. Konya.
3. Benjamin JF, Tang WHW, Lente FV, Peacock WF, Francis GS. 2002. Cardiac troponins in renal insufficiency. J Am Coll Cardiol. 40(12): 2065-2071.
4. Booth AJ, Naylor JM. 1987. Correction of metabolic acidosis in diarrheal calves by oral administration of electrolyte solutions with or without bicarbonate. JAVMA, 191(1): 62-68.
5. Boyd JW, Baker JR, Leyland A. 1974. Neonatal diarrhoea in calves. Vet Rec, 95, 310-313.
6. Brobst D. 1986. Review of the pathophysiology of alterations in potassium homeostasis. JAVMA, 188(9): 1019-1025.
7. Carslon GP. 1989. Fluid, Electrolyte, and Acid-Base Balance, chapter 19, in “Clinical Biochemistry of Domestic Animals” Editor, JJ Kaneko, 4th Ed., Academic Press Inc., New York.
8. Constable PD, Stampli HR, Navetat H, Bertchtold J, Schelcher F. 2005. Use of a quantitative strong ion approach to determine the mechanism for acid-base abnormalities in sick calves with or without diarrhoea. J Vet Intern Med. 19: 581-589.

9. Constable PD. 2004. Antimicrobial use in treatment of calf diarrhea. J Vet Intern Med, 18, 8-17.
10. Çitil M, Güneş V, Karademir B. 2003. 1996-2001 Yılları arasında Kafkas Üniversitesi Veteriner Fakültesi İç Hastalıkları Kliniğine getirilen ishalli buzağılar üzerine retrospektif bir çalışma. Kafkas Univ Vet Fak Derg, 9(1): 39-42.
11. Deshpande AP, Anantwar LG, Digraskar SU, Deshpande AR. 1993. Clinico-pathological and biochemical alterations in calf scour. Indian Vet J, 70, 679-680.
12. Fisher EW, Matinez AA. 1976. Aspectof body fluid Dynamics of neonatal calf diarrhea. Res Vet Sci, 20, 302-305.
13. Groutides CP, Michell AR. 1990. Changes in plasma composition in calves surviving or dying from diarrhoea. Br Vet J, 146, 205-210.
14. Gül Y. 1990. Yeni doğan buzağılarsa ishal ile seyreden enfeksiyöz hastalıklar. Türk Vet Hek Derg, 2(7-8): 48-54.
15. Güzelbekteş H, Çoşkun A, Şen İ. 2007. Relatıonshıp between the degree of dehydratıon and the balance of acıd-based changes ın dehydrated calves wıth dıarrhoea. Bull Vet Inst Pulawy. 51: 83-87.
16. Hall GA, Jones PW, Morgan JH. 1992. Calf diarhoea, chapter 12, in “Bovine Medicine Disease and Husbandry of Cattle” Editors, AH Andrews, RW Blowey, H Boyd, RG Eddy, 1st Ed., Blackwell Science Ltd.,Oxford, 1992.
17. Hunt E. 1993. Diarrheal diseases of neonatal ruminants. In Howard JL (Ed): Current Veterinary Therapy 3, Food Aniimal Practice. 103-110, W.B. Saunders Company, Philadelphia.
18. İmren HY. 1983. Buzağı ve kuzularda septisemik hastalıklar. Uludağ Üniv Vet Fak Derg. 2(2): 103Karademir B, Şendil Ç. 2001. E. Coli’nin neden olduğu ishalli buzağılarda klinik, hematolojik, biyokimyasal bulgular ve sağaltım uygulamalarının etkinliği. Kafkas Üniv Vet Fak Derg, 7(2):175-183.
19. Kasari TR. Naylor JM. 1984. Metabolic Acidosis Without Clinical Signs of Dehydration in Young Calves Can Vet J. 25: 394-399. 31