Komorbidli bir Köpekte Plateletten Zengin Fibrin’in (PRF) Yara İyileşmesi Üzerindeki Etkisi

Year 2024, , 162 - 168, 30.06.2024

Osman Bulut , Doğan Can Haney , Tolga Meriç Dümbek , Neslihan Sürsal Şimşek

https://doi.org/10.30607/kvj.1422396

Abstract

Platelet zengin fibrin (PRF) hastanın kendi trombositlerinden üretilen otojen bir materyaldir ve yara iyileşmesini ve doku rejenerasyonunu iyileştirmek için kullanılır. Bu vakada, farklı patojenlerle (Anaplasma, Canine Coronavirus, Pnömoni ve Sitrüvit Kristalleri) ilişkili doku hasarı olan bir köpekte PRF'nin yara iyileşmesi üzerindeki etkisi araştırılmıştır. PRF, yara bölgesine lokal olarak 21 gün boyunca uygulanmış ve yara bölgesi ile altta yatan kemik dokuda herhangi bir nekrotik doku olmadan iyileştiği gözlemlenmiştir. Bu durumda PRF'nin, multifaktöriyel bir hastalık tablosu ile birlikte oluşan doku kayıplı yaralanmalarda yara iyileşmesini ve doku rejenerasyonunu hızlandırdığı sonucuna varılmıştır.

Keywords

Anaplazma, Köpek, Multifaktöriyel hastalık, Platelet zengin fibrin

The Effect of Platelet-Rich Fibrin (PRF) on Wound Healing in A Dog with Comorbidities

Abstract

Platelet-rich fibrin (PRF) is an autogenous material produced from the patient's own platelets, used to improve wound healing and tissue regeneration. In this case report, the effect of PRF on wound healing is investigated in a dog with tissue damage associated with infection by different pathogens (Anaplasma, Canine Coronavirus, Pneumonia and Citruvite crystals). PRF was locally applied to the wound area for 21 days, and it was observed that the wound area and the underlying bone tissue healed without any necrotic tissue. It has been concluded that PRF accelerates wound healing and tissue regeneration in material loss tissue injuries accompanied by a multifactorial disease in this case.

Keywords

Anaplasma, Canine, Coronavirus, Multifactorial disease, Platelet-rich fibrin

References

• Campanholi, K. da S. S., Silva Junior, R. C. da, Gonçalves, R. S., Bassi da Silva, J., Pedroso de Morais, F. A., Said dos Santos, R., Vilsinski, B. H., Oliveira, G. L. M. de Pozza, M. S. dos S., Bruschi, M. L., Saraiva, B. B., Nakamura, C. V., & Caetano, W. (2022). Design and Optimization of a Natural Medicine from Copaifera reticulata Ducke for Skin Wound Care. Polymers, 14(21). https://doi.org/10.3390/polym14214483
• Choukroun, Joseph. , F. Adda. , C. Schoeffler. , A. Vervelle. (2001). Une opportunite´ en paro-implantologie: Le PRF. Implantodontie, 42, 55–62.
• Clipet, F., Tricot, S., Alno, N., Massot, M., Solhi, H., Cathelineau, G., Perez, F., De Mello, G., & Pellen-Mussi, P. (2012). In vitro effects of Choukroun’s platelet-rich fibrin conditioned medium on 3 different cell lines implicated in dental implantology. Implant Dentistry, 21(1),51–56. https://doi.org/10.1097/ID.0b013e31822b9cb4
• Dahmani, M., Davoust, B., Tahir, D., Raoult, D., Fenollar, F., & Mediannikov, O. (2017). Molecular investigation and phylogeny of Anaplasmataceae species infecting domestic animals and ticks in Corsica, France. Parasites and Vectors, 10(1). https://doi.org/10.1186/s13071-017-2233-2
• Davis, V. L., Abukabda, A. B., Radio, N. M., Witt-Enderby, P. A., Clafshenkel, W. P., Cairone, J. V., & Rutkowski, J. L. (2014). Platelet-rich preparations to improve healing. Part II: Platelet activation and enrichment, leukocyte inclusion, and other selection criteria. In Journal of Oral Implantology (Vol. 40, Issue 4, pp. 511–521). https://doi.org/10.1563/AAID-JOI-D-12-00106
• Desai, C., Kini, Y., Mahindra, U., & Bakshi, M. (2013). Use of platelet-rich fibrin over skin wounds: Modified secondary intention healing. Journal of Cutaneous and Aesthetic Surgery, 6(1), 35. https://doi.org/10.4103/0974-2077.110096
• Fan, Y., Perez, K., & Dym, H. (2020). Clinical Uses of Platelet-Rich Fibrin in Oral and Maxillofacial Surgery. In Dental Clinics of North America (Vol. 64, Issue 2, pp. 291–303). W.B.Saunders. https://doi.org/10.1016/j.cden.2019.12.012
• Iacopetti, I., Perazzi, A., Ferrari, V., & Busetto, R. (2012). Application of Platelet-Rich Gel to Enhance Wound Healing in the Horse: A Case Report. Journal of Equine Veterinary Science, 32(3), 123–128. https://doi.org/10.1016/j.jevs.2011.08.012
• Karimi, K., & Rockwell, H. (2019). The Benefits of Platelet-Rich Fibrin. In Facial Plastic Surgery Clinics of North America (Vol. 27, Issue 3, pp. 331–340). W.B. Saunders. https://doi.org/10.1016/j.fsc.2019.03.005
• Lektemur Alpan, A., & Torumtay Cin, G. (2020). PRF improves wound healing and postoperative discomfort after harvesting subepithelial connective tissue graft from palate: a randomized controlled trial. Clinical Oral Investigations, 24(1), 425–436. https://doi.org/10.1007/s00784-019-02934-9
• Lundquist, R., Dziegiel, M. H., & Ågren, M. S. (2008). Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin. Wound Repair and Regeneration, 16(3), 356–363. https://doi.org/10.1111/j.1524-475X.2007.00344.x
• Magyari M, Sorensen PS. Comorbidity in Multiple Sclerosis. Front Neurol. 2020 Aug 21;11:851. doi: 10.3389/fneur.2020.00851. PMID: 32973654; PMCID: PMC7473304.
• Pitzurra, L., Jansen, I. D. C., de Vries, T. J., Hoogenkamp, M. A., & Loos, B. G. (2020). Effects of L-PRF and A-PRF+ on periodontal fibroblasts in in vitro wound healing experiments. Journal of Periodontal Research, 55(2), 287–295. https://doi.org/10.1111/jre.12714
• Porsani, M. Y. H., Carvalho, L. A. R., Pereira, C. S., Paludetti, M., Zangeronimo, M. G., & Pereira, L. J. (2016). The use of papain gel cream and sunflower oil in promoting healing in a wound in dogs: Three case reports. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, 68(5), 1201–1206. https://doi.org/10.1590/1678-4162-8561
• Roy, S., Driggs, J., Elgharably, H., Biswas, S., Findley, M., Khanna, S., Gnyawali, U., Bergdall, V. K., & Sen, C. K. (2011). Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation. Wound Repair and Regeneration, 19(6), 753–766. https://doi.org/10.1111/j.1524-475X.2011.00740.x
• Scopelliti, F., Cattani, C., Dimartino, V., Mirisola, C., & Cavani, A. (2022). Platelet Derivatives and the Immunomodulation of Wound Healing. In International Journal of Molecular Sciences (Vol. 23, Issue 15). MDPI. https://doi.org/10.3390/ijms23158370
• Soares, C. S., Dias, I. R., Pires, M. A., & Carvalho, P. P. (2021). Canine-origin platelet-rich fibrin as an effective biomaterial for wound healing in domestic cats: A preliminary study. Veterinary Sciences, 8(10). https://doi.org/10.3390/vetsci8100213
• Tunali, M., Özdemir, H., Küçükodaci, Z., Akman, S., & Firatli, E. (2013). In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): A new platelet concentrate. British Journal of Oral and Maxillofacial Surgery, 51(5),438–443. https://doi.org/10.1016/j.bjoms.2012.08.003
• Underwood, J., Harvey, C., Lohstroh, E., Pierce, B., Chambers, C., Guzman Valencia, S., & Oliva Chávez, A. S. (2022). Anaplasma phagocytophilum Transmission Activates Immune Pathways While Repressing Wound Healing in the Skin. Life, 12(12). https://doi.org/10.3390/life12121965
• Wang, P. H., Huang, B. S., Horng, H. C., Yeh, C. C., & Chen, Y. J. (2018). Wound healing. In Journal of the Chinese Medical Association (Vol. 81, Issue 2, pp. 94–101). Elsevier Ltd. https://doi.org/10.1016/j.jcma.2017.11.002