Ehrlichiosis ile Enfekte Anemili Köpeklerde cTn I, CK-MB, Miyoglobin ve D-Dimer Seviyelerinin Belirlenmesi

Abstract

Ehrlichiosis birçok doku ve organı etkileyen, çoklu organ yetmezliklerine neden olabilen bir hastalıklır. Ehrlichianın yaygın damar içi pıhtılaşma (YDP) bozukluğu ve miyokardiyal hasar yönünden ne derece etkili ve önemli olduğu hala netlik kazanmamıştır. Anemi Ehrlichiosis’te yaygın görülen klinik tablolardan biridir. Yapılan bu çalışmada Ehrlichiosis’li hayvanlarda gelişen miyokardiyal hasar ve potansiyel YDP tablolarının anemi ile birlikte değerlendirilmesi amaçlandı. Çalışmanın hayvan materyali 10 sağlıklı, 24 mono-enfekte ve 9 ko-enfekte hayvandan oluşturuldu. Bunun yanında enfekte hayvanlar serolojik ve moleküler sonuçlarına göre aktif enfekte, enfekte ve akut enfekte; hastalık etkenlerine göre mono ve co enfekte, anemi durumlarına göre non anemik, hafif, orta ve şiddetli anemik olarak gruplandırıldı. Bu gruplarda cTnI, CK-MB ve miyoglobin seviyeleri, myokardiyal hasarın tespit edilmesi amacı ile ölçüldü. YDB profiline yatkınlığın belirlenmesi için D-Dimer konsantrasyonları saptandı. Elde edilen sonuçlar doğrultusunda D-Dimer konsantrasyonlarında anlamlı yükselmeler mono enfekte, co enfekte, hafif, orta ve şiddetli ile aktif enfekte gruplarında tespit edildi (p<0.05). Çıkan bu sonuçlar doğrultusunda, cTnI seviyelerinde mono enfekte, orta ve şiddetli anemili hayvanlar ile aktif enfekte gruplarında anlamlı istatistiksel farklar belirlendi (p<0.05). Diğer parametrelerde herhangi bir farklılığa rastlanmadı. Sonuç olarak Ehrlichia sonucu gelişen anemi doku ve organlarda iskemiye neden olarak, aneminin şiddeti ile uyumlu bir şekilde uzun süreli olgularda myokardiyal hasara sebep olduğu ve YDB profili geliştirdiği görüldü.

Keywords

• CK-MB
• cTn I
• D-Dimer
• Ehrlichia
• Miyoglobin.

Investigation of cTn I, CK-MB, Myoglobin and D-Dimer Levels at Anemic Dogs Infected with Ehrlichiosis

Abstract

Ehrlichiosis is a vector-borne disease that affects humans and animals. Multiple tissues and organs are fascinating, and Ehrlichiosis can cause multiple organ failure. In one’s way the known clinical findings and pathogenesis, it is not clear how Ehrlichia is effective and important on myocardial damage and disseminate intravascular coagulation (DIC) profile. Anemia is seen as one of the common clinical conditions in Ehrlichiosis. In this study, it was determined to state the existence of myocardial damage and thromboembolic condition at Ehrlichiosis with the severity of anemia. The animal material of this study consisted of 24 mono-infected, 9 co-infected, and 10 healthy animals. Additionally, animals were separated into mono, co-infected; with anemia profile non-anemic, mild, moderate, and severe anemic, and according to serologic and molecular results; acute infected, ınfected, and active ınfected. CK-MB, cTnI, and myoglobin levels were calculated in all groups to identify myocardial damage. Accordingly, D-Dimer concentrations were determined to set down the potential of the DIC profile. As a result of the data, D-Dimer levels significantly increased in mono, co-infected, mild, moderate, severe, and active infected animals (p<0.05). Significant statistical difference was seen in cTnI levels in mono, mild, moderate, and active infected groups (p<0.05). There were no significant statistical differences between CK-MB and myoglobin levels between study groups. As a result; It was observed that ischemia caused damage to the myocardium in the long view and composed DIC profile.

Keywords

• CK-MB
• cTn I
• D-Dimer
• Ehrlichia
• Miyoglobin.

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