Koyunlarda Meloksikamın Tekrarlanan İntravenöz Uygulamasını Takiben Farmakokinetiği

Abstract

Bu çalışmanın amacı, koyunlarda meloksikamın tekrarlanan intravenöz enjeksiyonunu takiben farmakokinetiğini belirlemektir. Araştırma 5 baş Merinos ırkı erkek koyun üzerinde gerçekleştirildi. Meloksikam koyunlara günde bir defa 5 gün boyunca 0.5 mg/kg dozunda intravenöz olarak uygulandı. Plazma örneklerinden meloksikam analizi yüksek basınçlı sıvı kromatografisi ile gerçekleştirildi. Farmakokinetik parametreleri kompartmansız analiz ile belirlendi. Meloksikamın ilk dozundan sonra ilk örnekleme zamanındaki plazma konsantrasyonu (C0.08), plazma konsantrasyon-zaman eğrisi altında kalan alan (AUC0-24), eliminasyon yarı ömrü (t1/2ʎz), toplam vücut klirensi (ClT) ve kararlı durum dağılım hacmi (Vdss) değerleri, sırasıyla 2.53 µg/mL, 12.30 saat*µg/mL, 8.97 saat, 0.03 L/saat/kg ve 0.40 L/kg olarak bulundu. İlk doza göre, son doz uygulamasından sonra AUC0-24 ve C0.08 artarken, ClT ve Vdss azaldı. İlk ve son uygulamayı takiben t1/2ʎz değerleri benzerdi. R1 ve R2 birikim seviyeleri sırasıyla 2.48 ve 2.81 idi. Sonuç olarak, koyunlarda meloksikamın tekrarlanan uygulanması farmakokinetik değişikliklere ve birikime neden oldu. Bu nedenle, koyunlarda tekrarlanan uygulamadan sonra meloksikamın güvenliği ve terapötik etkisi belirlenmelidir.

Keywords

• Damar içi
• Farmakokinetik
• Koyun
• Meloksikam
• Tekrarlanan doz

Pharmacokinetics of Meloxicam Following Repeated Intravenous Administrations in Sheep

Abstract

The purpose of this study was to investigate the pharmacokinetics of meloxicam following repeated intravenous injection in sheep. Five male merino sheep were used in the study. Meloxicam was administered intravenously to sheep at 0.5 mg/kg once daily for 5 days. Meloxicam analysis from plasma samples was performed by high-pressure liquid chromatography. Non-compartmental analysis was used to establish the pharmacokinetic parameters. Following the first dose of meloxicam, the values for the plasma concentration at the first sampling time (C0.08), area under the plasma concentration-time (AUC0-24), elimination half-life (t1/2ʎz), total body clearance (ClT), and volume of distribution at steady state (Vdss), were 2.53 µg/mL, 12.30 hour*µg/mL, 8.97 hour, 0.03 L/hour/kg, and 0.40 L/kg, respectively. Compared to the first dose, AUC0-24 and C0.08 increased, ClT and Vdss decreased after the last dose administration. Following the first and final administration, the t1/2ʎz values were similar. The accumulation levels of R1 and R2 were 2.48 and 2.81, respectively. In conclusion, repeated administration of meloxicam in sheep caused pharmacokinetic changes and accumulation. Therefore, the safety and therapeutic effect of meloxicam after repeated administration in sheep should be established.

Keywords

• Intravenous
• Meloxicam
• Pharmacokinetics
• Repeated dose
• Sheep

Supporting Institution

Bu araştırma herhangi bir kurum ve kuruluş tarafından desteklenmemektedir.

Ethical Statement

Araştırma Selçuk Üniversitesi Deney Hayvanları Yerel Etik Kurulu tarafından 26.03.2015 tarihinde ve 2015/03 numaralı oturumda görüşülmüş olup, 2015/30 numaralı kararınca etik kurul izni alınmıştır.

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