Kedide Bildirilen İlk Oral Flumetrin Toksisitesinin Klinik ve Laboratuvar Bulguları

Abstract

Flumetrin, α-siyano piretroitler grubunda yer alan, lipofilik yapısı nedeniyle uzun etki süresine sahip bir ektoparaziter ilaçtır. Oral alım sonrası emilimi yavaş olmakla birlikte sistemik dolaşımda uzun süre kalabilmesi, klinik belirtilerin gecikmeli ortaya çıkmasına ve daha uzun seyretmesine neden olmaktadır. Bu olgu sunumunda, köpeğe uygulanan flumetrin içeren topikal preparatı oral yolla alan bir kedide gelişen akut toksisite tablosu ele alınmıştır. Kedide hipersalivasyon, tremor ve letarji gibi nörolojik semptomlar gözlemlenmiş, laboratuvar bulgularında hepatik enzim seviyelerinde artış dikkat çekmiştir. Uygulanan semptomatik tedavi ile 14. günde klinik iyileşme görülmüş, 30. günde ise hematolojik ve biyokimyasal parametreler normale dönmüştür. Bu olgu, özellikle kedilerde piretroit maruziyetinin ciddi toksik etkilere yol açabileceğini göstermektedir.

Keywords

• Flumetrin
• piretroit
• toksikasyon

Ethical Statement

Bu çalışma, ‘Hayvan Deneyleri Etik Kurullarının Çalışma Usul ve Esaslarına Dair Yönetmelik’ 8(k) maddesi uyarınca HADYEK iznine tabi değildir. Bu makalede sunulan veri, bilgi ve belgeler akademik ve etik kurallar çerçevesinde elde edilmiştir.

Clinical and Laboratory Findings of the First Reported Oral Flumethrin Toxicity in a Cat

Abstract

Flumethrin is an ectoparasiticide drug belonging to the α-cyano pyrethroid group, which is a long-acting drug due to its lipophilic structure. Although its absorption after oral administration is slow, its ability to remain in systemic circulation for a long time causes clinical signs to appear later and persist longer. This case report discusses the acute toxicity observed in a cat that ingested a topical preparation intended for dogs and containing flumethrin. The cat exhibited neurological symptoms such as hypersalivation, tremors, and lethargy. Later laboratory findings revealed elevated hepatic enzyme levels. Clinical improvement was observed on day 14 following symptomatic treatment. Haematological and biochemical parameters returned to normal by day 30. This case demonstrates that exposure to pyrethroids may cause serious toxic effects, particularly in cats.

Keywords

• Flumethrin
• pyrethroid
• toxicity

Ethical Statement

This study is not subject to the permission of HADYEK in accordance with the “Regulation on Working Procedures and Principles of Animal Experiments Ethics Committees” 8 (k). The data, information and documents presented in this article were obtained within the framework of academic and ethical rules.

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