Geçiş Dönemindeki Süt İneklerinde Damar İçi Novacoc® Uygulamasının Metabolik Profil Üzerine Etkileri

Abstract

Sunulan çalışma süt ineklerine doğuma üç hafta kala, haftalık olarak yapılan damar içi Novacoc® enjeksiyonunun, erken laktasyon dönemde bazı kan, metabolizma ve bağışıklık parametreleri üzerine etkisini incelemek amacıyla yürütülmüştür. Çalışmada, 20 adet Holştayn ırkı süt ineği rastgele olarak kontrol ve uygulama olmak üzere iki gruba ayrılmıştır. Çalışma boyunca uygulama grubundaki ineklere, doğuma üç hafta kala başlayıp doğuma kadar devam edecek şekilde, her haftanın ilk üç günü uygulamak üzere günde 200 ml Novacoc® (Metamizol Sodyum; 40 mg, Asetilmetiyonin 40 mg, Kafein 3,5 mg, Kalsiyum Glukonat 100 mg, Magnezyum Glukonat 10 mg, Sodyum Dihidrojen Fosfat Dihidrat 4,02 mg, Glikoz monohidrat 200; İnterhas®, Türkiye) damar içi yavaş infüzyon şeklinde uygulanmıştır. Buzağılama günü “0 (sıfır)” kabul edilerek; tüm ineklerin kuyruk venasından (V.Coccygea) -21, -14, -7, 0, 7, 14, 21. günlerde hematolojik ve biyokimyasal analizler için örnekler alınmıştır. Kan total kolesterol, HDL, Trigliserit ve glukoz seviyeleri doğum sonrasında bazı günlerde istatiksel ancak tamamında sayısal olarak yüksek bulunmuş, NEFA ve BHBA seviyeleri ise düşük bulunmuştur. Öyle ki kontrol grubunun NEFA ve BHBA değerleri subklinik ketozis düzeyinde seyretmiştir. Bu verilere ek olarak laktasyonun ilk üç haftası süt verimi her iki grupta da benzer iken pik süt verimi uygulama grubunda anlamlı şekilde yüksek bulunmuştur.

Keywords

• Novacoc®,Metabolik Profil,Süt İnekleri,NEFA,BHBA

The Effects of Intravenous Novacoc® Treatment on Metabolic Profiles During the Transition Period of Dairy Cows

Abstract

This study was performed to evaluate the effect of weekly intravaneous administration of Novacoc®, 3 weeks before parturition on some hematological, metabolism, and immune parameters on early lactation period in dairy cows. In this study 20 random Holstein dairy cows has been used and divided into two groups as control group and the treatment group. The treatment started 3 weeks before parturation and ended parturaiton. The treatment has been made in first three days of each week. The animals in the treatment group were administered daily Novacoc®, 200 ml (Metamizol Sodium; 40 mg, Acetyl methionine 40 mg, Caffeine 3,5 mg, Calcium Gluconate 100 mg, Magnesium Gluconate 10 mg, Sodium Dihydrogen Phospate Dhydrate 4,02 mg, Glucose monohydrate 200; İnterhas®, Türkiye) as intravenous slowly infusion on first 3 days of each weeks during last 3 weeks of prepartum period and first 3 weeks of postpartum period. Parturition day was planned as day “0 (zero)”; blood samples were collected on days -21, -14, -7, 0, 7, 14, 21 from V. Coccygea of all cows. Total cholesterol, HDL, triglyceride, and glucose levels were significantly higher on some postpartum days; However, NEFA and BHBA levels were found decreased. NEFA and BHBA levels in the control group were detected as subclinical ketosis levels. In addition to this results, the milk yields of each group were measured as same during first 3 weeks of lactation, but peak milk yield on the treatment group increased significantly. 

Keywords

• Novacoc®,Metabolic Profile,Dairy Cows,NEFA,BHBA

References

1. Başoğlu A, Sevinç M, Ok M, Gökçen M. Peri and postpartur ient concentrations of lipid lipoprotein insulin and glucose in normal dairy cows. Tr. J. Of Veterinary and Animal Sciences. 1998; 22:141-144
2. Block, SS, Butler WR, Ehrhardt RA, Bell AW, Van Amburgh ME, Boisclair YR. Decreased concentrations of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 2001;171:339–348.
3. Cheng X, Zhe W, Yan-Fei L, Shu-ling N, Chuang X, Cai Z, Hong-You Z. Effect of hypoglycemia on performances, metabolites, and hormones in periparturient dairy cows. Agricultural Sciences in China. 2007; 6(4):505-512.
4. Cincovic RM, Belic B, Radojcic B, Hristov S, Đokovic R. Influence of lipolysis and ketogenesis to metabolic and hematological parameters in dairy cows during periparturient period. Acta Veterinaria, Beograd. 2012; 62(4):429-444
5. Cozzi G, Ravarotto L, Gottardo F, Stefani AL, Contiero B, Moro L, Brscic M, Dalvit P. "Short communication: Reference values for blood parameters in Holstein dairy cows: Effects of parity, stage of lactation, and season of production." J. Dairy Sci. 94.8 2011; 94(8):3895-3901
6. Drackley JK. Biology of Dairy Cows During the Transition Period: the Final Frontier?. J. Dairy Sci. 1999; 82:2259-2273.
7. Grummer RR. Impact of Changes in Organic Nutrient Metabolism on Feeding the Transition Dairy Cow. J. Anim. Sci. 1995; 73:2820–2833.
8. Grummer RR. Ethiology of lipid-related metabolic disorders in periparturient dairy cows. J. Dairy Sci. 1993; 76:3882–3896.

9. Huszenicza, Gyula, et al. "Adrenocortical and thyroid function, hormone and metabolite profiles and the onset of ovarian cyclicity in dairy cows suffering from various forms of ketosis." Acta veterinaria. 2006; 56(1): 25-36.
10. Jonsson, NN, Fortes MRS, Piper EK, Vankan DM, De Cisneros JPJ, Wittek T. "Comparison of metabolic, hematological, and peripheral blood leukocyte cytokine profiles of dairy cows and heifers during the periparturient period." Journal of dairy science. 2013; 96(4): 2283-2292.
11. Kalaitzakis E, Panousis N, Roubies N, Giadinis N, Kaldrymidou E, Georgiadis M, Karatzias H. "Clinicopathological evaluation of downer dairy cows with fatty liver." Canadian Veterinary Journal. 2010; 51(6): 615.
12. Kessel S, Stroehlt M, Meyer HHD, Hisst S, Sauerweint H, Schwartz FJ, Bruckmaier RM. "Individual variability in physiological adaptation to metabolic stress during early lactation in dairy cows kept under equal conditions." Journal of animal science. 2008; 86(11): 2903-2912.
13. McArt JAA, Nydam DV, Oetzel GR, Overton TR, Ospina PA. "Elevated non-esterified fatty acids and β-hydroxybutyrate and their association with transition dairy cow performance." The Veterinary Journal. 2013; 198(3): 560-570.
14. Overton TR, Waldron MR. Nutritional Management of Transition Dairy Cows: Strategies to Optimize Metabolic Health. J. Dairy Sci. 2004; 87:105-119.
15. Phillips GJ, Citron TL, Sage JS, Cummins KA, Cecava MJ, McNmara JP. Adaptations in body muscle and fat in transition dairy cattle fed differing amounts of protein and methionine hydroxy analog. Journal of Dairy Science. 2003; 86:3634-3647.
16. Reynolds CK, Aikman PC, Lupoli B, Humphries DJ, Beever DE. Splanchnic metabolism of dairy cows during the transition fromlate gestation through early lactation. J. Dairy Sci. 2003; 86:1201–1217.
17. Rubino G, Deramo S, Nocco A, Loglisci A, Lacinio R, Selvaggi M, Lacalandra GM. Evaluation of peripartum hematochemical and metabolic profileto identify cattle at risk for metritis. XIII Middle european Buiatric’s Congress. Belgrad, Sırbistan. 2013; 497-502 ,
18. Sahinduran S, Sezer K, Büyükoğlu T, Albay MK, Karakurum MC. Evaluation of some haematological and biochemical parameters before and after treatment in cows with ketosis and comparison of different treatment methods. J Anim Vet Adv. 2010; 9(2): 266-271.
19. Urton, G, Keyserlingk MAG, Wear, DM. "Feeding behavior identifies dairy cows at risk for metritis." Journal of Dairy Science. 2005; 88(8): 2843-2849.
20. Quiroz-Rocha, Gerardo F, LeBlanc SJ, Duffield TF, Wood D, Leslie KE, Jacobs RM. "Reference limits for biochemical and hematological analytes of dairy cows one week before and one week after parturition." The Canadian Veterinary Journal. 2009; 50(4):383.
21. Wallace RL, Mccoy GC, Overton TR, Clark JH. Effect of Adverse Health Events on Dry Matter Consumption, Milk Production, and Body Weight Loss of Dairy Cows During Early Lactation. J. Dairy Sci. 1996; 79(1): 205.