Tiroid Fonksiyon Bozukluklarında Fonksiyonel Besinlerin Etkinliği

Abstract

Günümüzde tiroid bezi hormonlarının sentez ve salınımındaki anormalliklere bağlı olarak gelişen direk ya da indirek hastalıklar insan ve hayvanların yaşam kalitesinde önemli rol oynamaktadır. Bu derlemede fonksiyonel besinler içinde yer alan tıbbi bitki türlerinin tiroid bezi metabolizması ve hormonlarına olan etkileri ile bezin çeşitli hastalıklarında koruyucu ya da iyileştirici olarak bitkilerin kullanılmasına ilişkin güncel çalışmalara yer verilmiştir.

Keywords

• Fonksiyonel besinler,Tıbbi bitkiler,Tiroid fonksiyon bozuklukları

Efficacy of Functional Foods in Thyroid Dysfunction

Abstract

Direct or indirect diseases that are caused by abnormalities in the synthesis and release of thyroid hormones play an important role in the quality of life of humans and animals nowadays. In this review, the current works on the use of plants as protective or healing in various diseases of the gland, and the effects of medicinal plant species in which functional foods category on the thyroid gland metabolism and hormones in the traditional way are given.

Keywords

• Functional foods,Medicinal plant,Thyroid dysfunction

References

1. Altay M, Ateş İ, Kaplan Efe F, Karadağ İ. Does use of anethum graveolens affected thyroid hormone levels and thyroid nodules. American Journal of Therapeutics. 2006; (0): 1-2.
2. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera) root. Indian J Exp Biol. 2000; (38): 607-609.
3. Ayaz E, Alpsoy HC. Sarımsak (Allium sativum) ve geleneksel tedavide kullanımı. Türkiye Parazitoloji Dergisi. 2007; 31(2): 145-149.
4. Barrett KE, Boitano S, Barman SM, Brooks HL. The Thyroid Gland In: Ganong’s Review of Medical Physiology. Ed; Ganong WF., 23rd Ed., Section IV Endocrine & Reproductive Physiology, Chapter 20, The McGraw-Hill Companies, Inc.,USA, 2010; pp. 290-315.
5. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr. Cancer. 1992; 18: 1-29.
6. Dudnic N. The prospect of using an extract of Juglans regia in the prevention of iodine deficiency diseases. PhD thesis, Moldova State University, 2009.
7. Farzaei MH, Abbasabadi Z, Ardekani MR, Rahimi R, Farzaei F. Parsley: a review of ethnopharmacology, phytochemistry and biological activities. J Tradit Chin Med. 2013;33(6):815-26. Review.
8. Jatwa R, Kar A. Amelioration of metformininduced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice. Phytotherapy Research. 2009; 23(8): 1140- 1145.

9. Hasler CM. Functional Foods: Benefits, Concerns and Challenges-A Position Paper from the American Council on Science and Health. The Journal of Nutrition. 2002; 132: 3772- 3781.
10. Kooti W, Ahangarpoor A, Ghasemiboroon M, Sadeghnezhadi S, Abbasi Z, Shanaki Z, Hasanzadeh-Noohi Z, Asadi-Samani M. Effect of apium graveolens leaf extract on serum level of thyroid hormones in male rat. Journal of Babol University of Medical Sciences. 2014; 16(11): 44-50.
11. Kumar Verma S, Kumar A. Therapeutic uses of Withania somnifera (ashwagandha) with a note on withanolides and its pharmacological actions. Asian Journal of Pharmaceutical and Clinical Research. 2011; 4: 1-4.
12. Lange D. 2004. Medicinal and aromatic plants: trade, production, and management of botanical resources. Acta Horticulturae. 2004; 629: 177-197.
13. Marshall ME, Mohler JL, Edmonds K, Williams B. An updated review of the clinical development of coumarin (1,2- benzopyrone) and 7-hydroxy coumarin. J. Cancer Res. Clin. Oncol. 1994; 120: 39-42.
14. Öztürk Y, Aydin S, Arslan R, Baser KHC, Kurtar-Öztürk N. Thyroid hormone enhancing activity of the fruits of Juglans regia L. in mice. Phytotherapy Research. 1994; 8(5): 308-310.
15. Panda S, Kar A. Changes in Thyroid Hormone Concentrations after Administration of Ashwagandha Root Extract to Adult Male Mice. Journal of Pharmacy and Pharmacology. 1998; 50(9): 1065-1068.
16. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Journal of Ethnopharmacology. 1999a; 67(2): 233-239.
17. Panda S, Kar A. Gugulu (Commiphora mukul) induces triiodothyronine production: Possible involvement of lipid peroxidation. Life Sciences. 1999b; 65(12): 137-141.
18. Panda S, Kar A. Guggulu ( Commiphora mukul ) potentially ameliorates hypothyroidism in female mice. Phytotherapy Research. 2005; 19(1): 78-80.
19. Panda S, Kar A. Amelioration of L-thyroxineinduced hyperthyroidism by coumarin (1,2-benzopyrone) in female rats. Clin Exp Pharmacol Physiol. 2007a; 34(11): 1217- 1219.
20. Panda S, Kar A. Apigenin (4’,5,7- trihydroxyflavone) regulates hyperglycaemia, thyroid dysfunction and lipid peroxidation in alloxan-induced diabetic mice. Journal of Pharmacy and Pharmacology. 2007b; 59(11): 1543-1548.
21. Panda S, Kar, A. Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: Possible involvement of quercetin. Phytomedicine. 2007c; 14(12): 799–805.
22. Panda S. The effect of anethum graveolens l. (dill) on corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Phytotherapy Research. 2008; 22: 1695-1697.
23. Panth N, Paudel KR, Karki R. Phytochemical profile and biological activity of Juglans regia. J İntegr Med. 2016; 14(5): 359–373.
24. Pereira JA, Oliveira İ, Sousa A, Valentão P, Andrade PB, Ferreira İC, Ferreres F, Bento A, Seabra R, Estevinho L. Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem Toxicol. 2007; (45): 2287-95.
25. Rouhi-Boroujeni H, Hosseini M, Gharipour M, Rouhi-Boroujeni H. Is herbal therapy safe in obesity? A case of Apium graveolens (Celery) induced hyperthyroidism. ARYA Atheroscler 2016; 12(5):248-249.
26. Taha N, Al-Wadaan M. Utility and importance of walnut, Juglans regia Linn: A review. African Journal of Microbiology Research. 2011; 5(32): 5796-5805.
27. Tahiliani P, Kar A. Mitigation of thyroxine induced hyperglycaemia by two plant extracts. Phytotherapy Research. 2003a; 17(3): 294-296.
28. Tahiliani P, Kar A. The combined effects of Trigonella and Allium extracts in the regulation of hyperthyroidism in rats. Phytomedicine. 2003b; 10(8): 665-668.
29. Tripathi YB, Malhotra OP, Tripathi SN. Thyroid stimulating action of Zguggulsterone obtained from commiphora mukul. Planta Med. 1984; 50(1): 78-80.