Parenteral Applications of Colostrum Serums in Treatment and Prevention of Neonatal Calf Diarrhea

Abstract

Calf diarrhea caused by infectious and non infectious factors is a commonly reported disease in young animals, and still a major cause of productivity and economic loss to cattle producers worldwide. The bovine placenta does not permit the passive transfer of antibody to the fetus. Thus, calves are born hypogammaglobulinemic, and consumption of colostrum is required to provide passive immunity until the immune system of the calf matures. Additionally, mean time to gut closure in calves occurs approximately 24 h after birth for IgG, IgA, and IgM. If calves do not ingest a sufficient mass of Ig prior to cessation of macromolecular transport, morbidity and mortality may increase. New techniques are needed to provide Ig to hypogammaglobulinemic calves after cessation of macromolecular transport by the intestinal epithelia. Once the period of intestinal permeability to immunoglobulin molecules has passed, passive immunity can be provided through parenteral injections. In this article, our objective is to review the effects of colostrum whey injections on prevention of diarrhea as well as health and growth performance in calves.

Keywords

• Regional İmmunisation,Calves,Colostrum Whey,Preventive,Treatment

Neonatal Buzağı İshallerinin Tedavi ve Korunmasında Kolostrum Serumlarının Parenteral Uygulamaları

Öz

İnfeksiyöz ve non-infeksiyöz nedenlerden kaynaklanan buzağı ishalleri genç hayvanlarda en sık bilidirilen ve sığır yetiştiriciliğinde hala dünyada en önemli üretim ve ekonomik kayıp nedenlerinden birisidir. Sığır plasentası antikorların pasif transferine izin vermez. Bu nedenle, buzağılar hipogammaglobulinemik doğarlar ve kendi immun sistemleri gelişinceye kadar annelerinin sağladıkları kolostrum ile pasif bağışıklığa ihtiyaç duyarlar. Ayrıca, doğumdan sonraki 24 saatten sonra bağırsak IgG, IgA ve IgM'nin emilimine kapanır. Eğer buzağılar bu zamandan önce yeterince bu makromoleküllerden almazlarsa morbidite ve mortalite artar. Bağırsak epitellerince makromoleküllerin emiliminin kesildiği bu hipogammaglobulinemik buzağılarda bu Ig sağlayacak yeni tekniklere ihtiyaç duyulmaktadır. İmmunglobulin moleküllerinin intestinal absorbsiyonunun süresi geçer geçmez, pasif immünite parenteral enjeksiyonlarla sağlanabilir. Bu makaledeki amacımız, ishalli buzağılarda parenteral kolostrum serumunun ishalden korunma ve büyüme performansı üzerine etkilerini derlemektir. 

Anahtar Kelimeler

• Bölgesel Bağışıklık,Buzağı,Kolostrum Serumu,Koruma,Tedavi

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