Epidermal Büyüme Faktörü

Abstract

Epidermal büyüme faktörü, hücrelerin bölünmesi, farklılaşması, yaşaması, çoğalması, büyümesi ve hücre göçünü uyaran protein yapıda bir büyüme faktörü olup, organizmadaki pek çok fizyolojik ve patolojik süreçte rol almaktadır. EGF, anti-enflamatuar, anti-apoptotik, nörotrofik ve nöroprotektif etkilere sahiptir. Epidermal büyüme faktörü reseptörleri akciğer, mide, duodenum, pankreas, böbrek, hipofiz bezi, tiroid bezi, meme bezi, yumurtalık, uterus, plasenta, kornea ve gliya hücrelerinde bulunmaktadır. Trombositler, makrofajlar, monositler ve fibroblastlar da epidermal büyüme faktörü kaynağıdır. Epidermal büyüme faktörü, epidermal büyüme faktörü reseptörüne bağlanarak, MAPK, ERK 1/2, PI3K-Akt, PLC-γ, JAK/STAT hücre içi sinyalizasyon yolaklarını aktive ederek etki etmektedir. Epidermal büyüme faktörü etkilerini başlıca sindirim sistemi, üreme sistemi ve sinir sistemi üzerinde göstermektedir. Fibroblastların, kerotinisitlerin, vasküler endotel hücrelerinin büyümesini ve çoğalmasını uyarıcı etkisi nedeniyle, özellikle yaraların tedavisinde epidermal büyüme faktörü uygulamaları başarı sağlamaktadır. Bu derlemenin amacı, EGF’nin yapısı, kaynakları, reseptörü, etki mekanizması, etkileri ve tedavide kullanımını özetlemektir.

Keywords

• Epidermal Büyüme Faktörü,Epidermal Büyüme Faktörü Reseptörü

Epidermal Growth Factor

Abstract

Epidermal growth factor is a growth factor in protein structure that stimulating division, differentiation, survival, proliferation, growth and migration of the cells which takes role in many physiological and pathological processes of the organism. EGF has anti-inflammatory, anti-apoptotic, neuroprotective and neurotrophic effects. Epidermal growth factor receptors are located on the cell surface of many tissues that include lung, stomach, duodenum, pancreas, kidney, pituitary gland, thyroid gland, mammary gland, ovary, uterus, placenta, cornea and glia. Platelets, macrophages, monocytes and fibroblasts are also source of epidermal growth factor. EGF exerts its effects through binding to EGFR mainly by activating MAPK, ERK 1/2, PI3K-Akt, PLC-γ, JAK/STAT intracellular signaling pathways. Epidermal growth factor exerts its effect mainly on the digestive, reproductive and nervous system. Epidermal growth factor administration especially in treatment of wounds has success because of its stimulating effect on growth and proliferation of fibroblasts, keratinocytes and vascular endothelial cells. The aim of this review is to summarize the structure, sources, receptor, effect mechanism, effects and for use in therapy of epidermal growth factor.

Keywords

• Epidermal Growth Factor,Epidermal Growth Factor Receptor

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