Vitamin D Levels in Cat and Dogs With Ehlers-Danlos Syndrome: Case Series Touching Nutritional Deficiency Hypothesis

Year 2018, , 339 - 343, 01.09.2018

Hasan Erdoğan , Kerem Ural Deniz Sude Ateş , Pelin Kandemir

https://doi.org/10.30607/kvj.426518

Abstract

Ehlers Danlos
syndrome (EDS) reported varied animal species is a rare hereditary collagen
disorder standing out  reduced strength
of skin being hyperextensible, velvety and fragile. Diagnosis of also termed
dermatosparaxis or cutaneous asthenia in animals is based on  classic clinical symptoms, skin extensibility
index with histopathologic examination included thin, unregular seperated
collagen bundles. In the presented case series enrolled different ages (1-3
years old 4 cats; and 1-5 years old 6 dogs) with both gender cats (2 males, 2
females) and dogs (4 males, 2 females) has been conferred serum 25 (OH) D3
levels associations. Just as dog and cats diagnosed with EDS found lower
vitamin D levels (total 8 of 10) are considered, it has recommended in cat and
dogs with EDS taking into account of vitamin D deficiency as well as some other
nutritional deficiencies and giving oral vitamin D supplements with safety as
human medicine. 

Keywords

Ehlers-Danlos Syndrome, cat, dog, vitamin D

Ehlers-Danlos Sendromlu Kedi ve Köpeklerde D Vitamini Düzeyleri: Nutrisyonel Bozukluk Hipotezine Dair Olgu Serisi

Abstract

Farklı hayvan
türlerinde bildirilen ve derinin elastikiyetinde azalma, deride aşırı uzama,
yumuşama bulgular gösteren Ehlers Danlos Sendromu (EDS) nadir görülen kalıtsal
kollojen hastalığıdır. Hayvanlarda dermatosparaksis ve kutanöz astenia olarak
da bilinen bu hastalığın tanısı klasik klinik bulgular, cilt uzayabilirlik
indeksi ile histopatolojide kalın, düzensiz ayrılmış kollojen demetlerinin
görülmesine dayanmaktadır. Farklı yaş (n=4 kedi; 1-3 yaşlı ile n=6 köpek 1-5
yaşlı), her 2 cinsiyetten kedi (2 erkek, 2 dişi) ve köpeğin (4 erkek, 2 dişi)
dahil edildiği olgu serisinde serum 25 (OH) D3 seviyeleri ile ilişkileri
sunulmaktadır. EDS tanısı konulan kedi ve köpeklerde bulunan düşük vitamin D
seviyeleri (toplamda 8/10) düşünüldüğünde EDS’ li kedi ve köpeklerde diğer
beslenme eksikliklerinin yanı sıra vitamin D yetersizliğinin de göz önüne
alınması gerektiği ve beşeri hekimlikte olduğu gibi oral vitamin D takviyesinin
güvenle verilebileceği önerilmektedir. 

Keywords

Ehlers-Danlos Sendromu, kedi, köpek, vitamin D

References

• Pyeritz RE. Ehlers-Danlos syndrome. N Engl J Med. 2000; 342(10):730–2.
• De Paepe A, Malfait F. The Ehlers-Danlos syndrome, a disorder with many faces. Clin Genet. 2012; 82(1):1–11.
• Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ. Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). Am J Med Genet. 1998; 77(1):31–7.
• Beighton P, de Paepe A, Danks D, Finidori G, Gedde-Dahl T, Goodman R, Hall JG, Hollister DW, Horton W, McKusick VA, et al. International nosology of heritable disorders of connective tissue, Berlin, 1986. Am J Med Genet.1988; 29(3):581–94.
• Germain DP. Ehlers-Danlos syndrome type IV. Orphanet J Rare Dis. 2007; 2:32.
• De Felice C, Bianciardi G, Dileo L, Latini G, Parrini S. Abnormal oral vascular network geometric complexity in Ehlers-Danlos syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 98(4):429–34.
• Lum YW, Brooke BS, Black 3rd JH. Contemporary management of vascular Ehlers-Danlos syndrome. Curr Opin Cardiol. 2011; 26(6):494–501.
• Oderich GS, Panneton JM, Bower TC, Lindor NM, Cherry KJ, Noel AA, Kalra M, Sullivan T, Gloviczki P. The spectrum, management and clinical outcome of Ehlers-Danlos syndrome type IV: a 30-year experience. J Vasc Surg. 2005; 42(1):98–106.
• Pepin M, Schwarze U, Superti-Furga A, Byers PH. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type. N Engl J Med. 2000; 342(10):673–80.
• Bergqvist D, Bjorck M, Wanhainen A. Treatment of vascular Ehlers-Danlos syndrome: a systematic review. Ann Surg. 2013; 258(2):257–61.
• Busch A, Suellner J, Anger F, Meir M, Kickuth R, Lorenz U, Wildenauer R. Critical care of kyphoscoliotic type Ehlers-Danlos syndrome with recurrent vascular emergencies. VASA Zeitschrift fur Gefasskrankheiten. 2014; 43(3):216–21.
• Horowitz MB, Purdy PD, Valentine RJ, Morrill K. Remote vascular catastrophes after neurovascular interventional therapy for type 4 Ehlers-Danlos Syndrome. AJNR Am J Neuroradiol. 2000; 21(5):974–6.
• Malfait F, De Paepe A. Bleeding in the heritable connective tissue disorders: mechanisms, diagnosis and treatment. Blood Rev. 2009; 23(5):191–7.
• Asherson RA, Bosman C, Tikly M, Spiro F, Pope FM. Ehlers-Danlos syndrome type IV in a young man. J Rheumatol. 2006; 33(10):2091–6.
• Calatzis A, Heesen M, Heesen M, Spannagl M. [Point-of-care testing of hemostatic alterations in anaesthesia and intensive care]. Anaesthesist. 2003; 52(3):229–37.
• Lindsay H, Lee-Kim YJ, Srivaths LV: Perioperative Hemostatic Management in Ehlers-Danlos Syndrome: A Report of 2 Cases and Literature Review. Journal of pediatric hematology/oncology. 2015
• Yenicesu I, Uckan D, Soysal A, Buyukasik Y, Gumruk F. Platelet release defect in a child with Ehlers-Danlos syndrome. Pediatr Hematol Oncol. 2000; 17(2):193–4.
• Morissette R, Schoenhoff F, Xu Z, Shilane DA, Griswold BF, Chen W, Yang J, Zhu J, Fert-Bober J, Sloper L, et al. Transforming growth factor-beta and inflammation in vascular (type IV) Ehlers-Danlos syndrome. Circ Cardiovasc Genet. 2014; 7(1):80–8
• Wong MS, Leisegang MS, Kruse C, Vogel J, Schurmann C, Dehne N, Weigert A, Herrmann E, Brune B, Shah AM, et al. Vitamin D promotes vascular regeneration. Circulation. 2014; 130(12):976–86.
• Busch A, Hoffjan S, Bergmann F, Hartung B, Jung H, Hanel D, Tzschach A, Kadar J, Kodolitsch Y, Christoph-Thomas Germer, Trobisch H, Strasser E and Wildenauer R. Vascular type Ehlers-Danlos syndrome is associated with platelet dysfunction and low vitamin D serum concentration. Orphanet Journal of Rare Diseases. 2016; 11:111