Investigation of Serum and Wool Levels of Cobalt, Manganese, Selenium and Zinc in Liver-Trematode-Infected Sheep

Abstract

In this study, the hematological and biochemical blood values and the differences in serum and wool trace elements (cobalt [Co], manganese [Mn], zinc [Zn], and selenium [Se]) were compared in healthy and liver-trematode-infected sheep. A total of 100 ovines (80 trematode-infected and 20 healthy sheep) were included. The trematode-infected sheep had significantly greater (P<0.01) leucocyte (WBC), neutrophil (Neu), and eosinophil (Eo) values and significantly lower (P<0.01) erythrocyte (RBC), hematocrit (Hct), and hemoglobin (Hb) values when compared with the healthy control group. The trematode-infected sheep had significantly higher serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transferase (GGT) enzyme activity values when compared with the healthy control group (P<0.01, P<0.05, and P<0.01, respectively). Serum and wool Co, Mn, Zn, and Se levels were significantly lower (P<0.01) in the trematode-infected sheep than in the healthy control group. The effect of liver infections on trace element concentrations was determined to be similar in measurements in wool and serum. Decreases in trace element concentrations were mostly attributed to changes in the biotransformation of trace elements induced by pathologic disorders in the liver.

Keywords

• Liver-trematode,Serum,Sheep,Trace element,Wool

Karaciğer Trematodlu Koyunların Serum ve Yapağılarında Kobalt, Mangan, Selenyum ve Çinko Düzeylerinin Araştırılması

Abstract

Bu çalışmada sağlıklı ve karaciğer trematodu ile enfekte olmuş koyunlarda hematolojik ve biyokimyasal kan değerleri ile serum ve yün eser elementlerindeki (kobalt [Co], mangan [Mn], çinko [Zn] ve selenyum [Se]) farklılıklar karşılaştırılmıştır. Bu amaçla 80 baş karaciğer trematodlu ve 20 baş da sağlıklı olmak üzere toplam 100 baş koyun kullanıldı. Karaciğer trematodlu koyunların lökosit (WBC), nötrofil (Neu) ve eozinofil (Eo) düzeyleri kontrol grubunun aynı parametrelerinden istatistiki olarak önemli düzeyde yüksek (P<0,01) tespit edilirken, eritrosit (RBC), hematokrit (Hct) ve hemoglobin (Hb) değerleri daha düşük (P<0,01) bulunmuştur. Karaciğer trematodlu koyunların alanin aminotransferaz (ALT), aspartat aminotransferaz (AST) ve gamma glutamil transpeptidaz (GGT) değerleri sağlıklı koyunların aynı parametrelerine göre sırasıyla P<0,001, P<0,005 ve P<0,001 düzeylerinde yüksek tespit edildi. Karaciğer trematodlu koyunların serum ve yün Co, Mn, Zn ve Se seviyeleri sağlıklı koyunlara göre istatistiksel olarak önemli düzeyde düşük bulunmuştur (P<0,01). Karaciğer enfeksiyonlarının iz element konsantrasyonları üzerindeki etkisinin yün ve serumdaki ölçümlerinin benzerlik gösterdiği saptanmıştır. Karaciğer trematodlu koyunların serum ve yün iz elementlerin konsantrasyonundaki düşüşlerin karaciğerdeki patolojik bozukluklarına bağlı olarak oluşan iz elementlerin biyotransformasyonundaki değişimlerinde kaynaklanabileceği düşünülmektedir. 

Keywords

• Karaciğer trematodu,Serum,Koyun,İz element,Yün

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