Bupropion Etanole Maruz Kalan Ratlarda Biyokimyasal Parametreleri İyileştirir

Öz

Günümüzde alkol alımı sindirim sistemi hastalıkları başta olmak üzere birçok hastalığın önemli bir etkenidir. Dopamin agonistlerinin alkol kaynaklı hasarlar üzerinde iyileşmeye yardımcı olduğunun bilinmesine karşın, bupropionun etanol kaynaklı değişen biyokimyasal parametreler üzerindeki etkileri tam olarak açıklığa kavuşturulmamıştır. Bu çalışma etanol uygulaması ile değişen bazı biyokimyasal parametreler üzerinde bupropionun etkisini değerlendirmek için gerçekleştirildi. Çalışmada ratlara haftada iki kez dört hafta süreyle % 56 etanol uygulaması yapıldı ve sonrasında bupropion 30 ve 60 mg/kg dozlarda yedi gün süreyle oral olarak uygulandı. Çalışma sonunda bupropionun etanol ile değişen aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), alkalin fosfataz (ALP), üre, kreatinin, total protein ve glukoz değerlerini tersine çevirdiği belirlendi. Çalışma bulguları alkol uygulaması ile değişen biyokimyasal parametreleri bupropionun etkili bir şekilde iyileştirdiğini göstermiştir.

Anahtar Kelimeler

• Bupropion
• etanol
• biyokimyasal parametreler
• rat

Bupropion Improves Biochemical Parameters of Ethanol Exposure in Rats

Abstract

Today, alcohol intake is a significant factor in many diseases primarily digestive system disorders. Despite dopamine agonists for helping to heal on alcohol-induced damages was known, the effects of bupropion on ethanol-induced varying biochemical parameters were not clarified completely. This study was conducted to assess the effects of bupropion on some changing biochemical parameters due to ethanol treatment. Rats were administered with 56% ethanol twice a week for four weeks and then bupropion was orally administered in doses of 30 and 60 mg/kg for 7 days. At the end of the study, it was found that bupropion reversed the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, creatinine, total protein, and glucose changed by ethanol. Study findings proved that bupropion improved effectively the changed biochemical parameters due to alcohol administration.

Keywords

• Bupropion
• ethanol
• biochemical parameters
• rat

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