Review
BibTex RIS Cite

Leptin ve Diğer Hormonlar Üzerindeki Etkileri

Year 2015, Volume: 8 Issue: 1, 75 - 83, 01.06.2015

Abstract

Leptinin etkilerinin anlaşılması hayvanlarla yapılan ve önemli ipuçları bırakmaya devam eden fizyoloji, metabolizma ve hücresel sinyalizasyon deneylerinden kaynaklanmıştır. Leptin keşfedilmesinden bu yana, bazı metabolitler ve hormonlar ile çeşitli yollarla bağlantılı olmuştur. Leptin özellikle kalori kısıtlaması ve açlığa uyum sırasında hipotalamus-hipofiz fonksiyonlarını etkiler. Leptindeki düşüş tiroid hormonu, büyüme hormonu ve cinsel hormonların salgılanmasını sınırlayarak ve kortizol salınımını artırarak enerji harcamasını azaltmak için bir sinyaldir. Bazı etkiler ön hipofiz hücreleri tarafından doğrudan leptini bağlayarak meydana gelebilmektedir. Ancak, leptin sinyaline esas olarak hipotalamik çekirdek içinde yer alan reseptörler aracılık eder. Ayrıca leptin bu dokularda bulunan leptin reseptörleri aracılığıyla tiroid ve böbreküstü bezi fonksiyonlarını düzenleyebilir. Son olarak, leptin dokulardan farklı adipokinlerin salgılanmasını değiştirebilir ve adipoz doku fonksiyonu üzerine doğrudan etkide bulunabilir. Böylece leptin metabolik bir sinyal olarak, birçok endokrin sistem üzerinde önemli düzenleyici etkilere sahiptir.

References

  • Ahima RS, Flier JS. Leptin. Annu.Rev.Physiol. 2000; 62: 413-437.
  • Alikaşifoğlu A. Enerji metabolizmasının düzenlenmesinde hormonların ve nörotransmitterlerin rolü. Katkı Pediatri Dergisi. 2000; 21(4): 492-499.
  • Andrews J.F. Leptin: energy regulation and beyond to a hormone with pan-physiological function. Proc Nutr Soc. 1998; 57: 409-411.
  • Aslan K., Serdar Z., Tokullugil A. Multifonksiyonel Hormon: Leptin. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2004; 30(2): 113-118.
  • Bocquier F, Bommet M, Faulconnier Y, Guerre-Millo M, Martin P, Chilliard Y. Effects of photoperiod and feeding level on perirenal adipose tissue metabolic activity and leptin synthesis in the ovariectomized ewe. Reprod Nutr Develop. 1998; 38: 489-498.
  • Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Diabetes. 1997; 46: 1235-1238.
  • Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996; 84: 491-495.
  • Chilliard Y, Bonnet M, Delavaud C, Faulconniera Y, Lerouxb C, Djianec J, Bocquierd F. Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Dom.Anim.Endocrinol. 2001; 21: 271-295.
  • Correia ML, Morgan DA, Sivitz WI, Mark AL, Haynes WG. Leptin acts in the central nervous system to produce dosedependent changes in arterial pressure. Hypertension. 2001; 37: 936-942.
  • Dagogo JS, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese andnonobese humans (abstract). Diabetes. 1996; 45: 695-698.
  • De Boer H, Blok G-J, van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews. 1995; 16: 63-86.
  • Delavaud C, Ferlay A, Faulconnier Y, Bocquier F, Kann G, Chilliard Y. Plasma leptin concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J.Anim. Sci. 2002; 80: 1317-1328.
  • Emilsson V, Liu Y, Cawthorne MA, Morton NM. Devenport M. Expression and functional leptin receptor mRNA in pancreaticislets and direct inhibitory action of leptin on insulin secretion. Diabetes. 1997; 46: 313-316.
  • Ersoy E, Bayşu N. Biyokimya. Ankara Ünivesitesi Veteriner Fakültesi Yayınları No: 408. Ders Kitabı. 1986. S: 553-559.
  • Eryavuz A, Avci G, Celik HA, Kucukkurt I. Plasma leptin, insulin, glucose, and urea concentrations throughout lactation in dairy cows. Bull Vet Inst Pulawy. 2008; 52(3): 381-385.
  • Eryavuz A, Avci G, Kucukkurt I, Fidan AF. Comparison of plasma leptin, ınsulin and thyroid hormone concentrations and some biochemical parameters between fat-tailed and thin-tailed sheep breeds. Revue de Médecine Vétérinaire. 2007; 158(5): 244-249.
  • Escobar-Morreale HF, Escobar del Rey F, Morreale de Escobar G. Thyroid hormones influence serum leptin concentrations in the rat. Endocrinology. 1997; 138, 4485–4488.
  • Fain J, Coronel E, Beauchamp M, Bahouth S. Expression of leptin and beta 3-adrenergic receptors in rat adipose tissue in altered thyroid states. Biochemical Journal. 1997; 322: 145–150.
  • Fei H, Okano HJ. Li C, Lee GH, Zhao C Darnell R, Friedman JM. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. U.S.A. 1997; 94 (13): 7001-7005.
  • Florkowski CM, Collier GR, Zimmet PZ, Livesey JH, Espiner EA, Donald RA. Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol. 1996; 45: 769- 773.
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mamals. Nature. 1998; 395: 763-770.
  • Gualillo O, Lago F, García M, Menéndez C, Señarís R, Casanueva FF, Diéguez C. Prolactin stimulates leptin secretion by rat white adipose tissue. Endocrinology; 1999; 140: 5149- 5153.
  • Güven Ş, El-Bershawi A, Sonnenberg GE, Wilson CR, Hoffmann RG, Krakower GR, Kissebah AH. Diabetes. 1999; 48: 347-352.
  • Haris RB. Acute and chronic effects of leptin on glucose utilization in lean mice. Biochem. Biophys. Res. Commun. 1998; 245 (2): 502-509.
  • Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E. et al. Augmented growth hormone secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. Journal of Clinical Endocrinology and Metabolism. 1992; 74: 757-765.
  • Harvey J, Mc Kenna F, Herson PS, Spanswick D, Ashford LJ. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J physiol. 1997; 504: 527-535.
  • Hekimoğlu A. Metabolik Sendromda Adiponektin. Harran Üniversitesi Tıp Fakültesi Dergisi. 2007; 4(2): 61-68.
  • Houseknecht KL, Baile CA, Matteri RL, Spurlock ME. The biology of leptin: a review. J.Anim.Sci. 1998; 76: 1405-1420.
  • Houseknecht KL, Portocarrero CP, Ji S, Lemenager R, Spurlock ME. Growth hormone regulates leptin gene expression in bovine adipose IGF-1 expression. J Endocrinol. 2000; 164: 51-57.
  • Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, Fujimiya M. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004; 18: 439-456.
  • Iraklinaou S, Melidonis A, Tournis S, Konstandelou E, Tsatsoulis A, Elissaf M, Sideris D. Postprandial leptinresponses after an oral fat tolerance test. Diabetes Care. 2001; 24: 1299-1300.
  • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes. 2001; 50: 2438-2443.
  • Kauter K, Ball M, Kearney P, Tellam R, McFarlane JR. Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA. J. Endocrinol. 2000; 166: 127-135.
  • Kielar D, Clark JS, Ciechanowicz A, Kurzawski G, Sulikowski T, Naruszewicz M. Leptin receptor isoforms expressed in human adipose tissue. Metabolism. 1998; 47: 844-847.
  • Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Hanry R, Mudaliar SR, Olefsky J, Caro JF. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro (abstract). Diabetes. 2001; 45: 699-701.
  • Kucukkurt I, Akbel E, Karabag F, Ince S. The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicology and Industrial Health. Doi: 10.1177/0748233712469648. 2013.(Baskıda).
  • Kucukkurt I, Dundar Y. Effects of dietary Yucca schidigera supplementation on plasma leptin, insulin, iodated thyroid hormones and some biochemical parameters in rats. Revue de Medecine Veterinaire. 2013; 164(7): 362-367.
  • Küçükkurt İ. Diyete katılan farklı miktarlardaki Yucca schidigera tozunun sıçanlarda plazma leptin, insulin ve tiroid hormonları ile bazı biyokimyasal parametrelere etkilerinin araştırılması. Doktora Tezi. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü, Afyonkarahisar, 2007.
  • Lengyel AM. Novel mechanisms of growth hormone regulation: growth hormone releasing peptides and ghrelin. Braz J Med Biol Res. 2006; 39: 1003-1011.
  • Lin Y, Matsumura K, Fukuhara M, Kagiyama S, Fujii K, Iida M. Grelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension. 2004; 43(5): 977-982.
  • Lönnqvist F, Wennlund A, Arner P. Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obesity. 1997; 21: 255-260.
  • Madej T, Boguski MS, Bryant SH. Threading analysis suggest that the obese gene product may be a helical cytokine. FEBS Letters. 1995; 373: 13-18.
  • Malmström R, Taskinen MR, Karonen SL, Jarvinen HY. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia. 1996; 39: 993-996.
  • Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. International J. of Obesity. 2002; 26: 1407-1433.
  • Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol. 2002; 147: 173-180.
  • Medina-Gomez G, Rosa-Maria C, Maria-Jesus O. T3 and Triac inhibit leptin secretion and expression in brown and white rat adipocytes. Biochimica et Biophysica Acta. 2004; 1682: 38-47.
  • Mercer JG, Moar KM, Findlay PA, Hoggard N, Adam CL. Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem. Regul. Pept. 1998; 75-76: 271-278.
  • Nagatani S, Zeng Y, Keisler DH, Foster DL, Jaffe CA. Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the shepp. Endocrinology. 2000; 141: 3965-3975.
  • Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K. Hemodynamic and hormonal effects of human grelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol. 2001; 280(5): 1483-1487.
  • Ren MQ, Wegner J, Bellmann O, Brockmann GA, Schneider F, Teuscher F, Ender K. Comparing mRNA levels of genes encoding leptin, leptin receptor, and lipoprotein lipase between dairy and beef cattle. Dom.Anim.Endocrinol. 2002; 23: 371-381.
  • Roh S, Clarke IJ, Xu R, Goding JW, Loneragan K, Chen C. The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland. Neu-roendocrinology. 1998; 68(6): 361-364.
  • Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature. 1995; 377: 527-529.
  • Scacchi M., Pincelli A., Cavagnini F. Growth hormone in obesity. International Journal of Obesity. 1999; 23: 260-271.
  • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HFA.. Novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem, 1995; 270: 26746-26749.
  • Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab. 1999; 84: 670-676.
  • Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem. 1996; 271: 5301-5304.
  • Stenvinkel P. Leptin. In: Shaul G. Massry, Richard J. Glassock (ed). Textbook of Nephrology, Fourth Edition, Lippincott Williams&Wilkins, Philadelphia. 2001; pp.1367- 1371.
  • Tallman D.L., Taylor C.G. Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2. Can J Physiol Pharmacol. 1999; 77: 919-933.
  • Tartaglia L A, Demski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995; 83: 1263-1271.
  • Towhidi A, Rostami F, Khazali H, Ahadi AH. The effect of energy intake level, body condition score, and leptin on ovulation rate in fat-tailed ewes. Proceedings of the British Society of Animal Science. 2002; 80.
  • Trayhurn P, Duncan JS, Rayner DV. Research communication acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system. Biochem. J. 1995; 311: 729-733.
  • Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000; 407: 908- 913.
  • Viengchareun S, Zennaro MC, Pascual-Le Tallec L, Lombes M. Brown adipocytes are novel sites ofexpression and regulation of adiponectin and resistin. FEBS Lett. 2002; 532: 345-350.
  • Wallace A.M. Measurement of leptin and leptin binding in the human circulation. Ann Clin. Biochem. 2000; 37 (3): 244-252.
  • Wauters M., Considine R.V., Van Gaal L.F. Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol. 2000; 143: 293-311.
  • Williams GL, Amstalden M, Garcia MR, Stanko RL, Nizielski SE, Morrison CD, Keisler DH. Leptin and its role in the central regulation of reproduction in cattle. Dom.Anim.Endocrinol. 2002; 23: 339-349.
  • Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD. Daily metatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology. 2000; 141: 487-497.
  • Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR. Ghrelin causes hyperphagia and obesity in rats. Diabetes. 2001; 50: 2540-2547.
  • Yaman K. Fizyoloji. Uludağ Üniversitesi Güçlendirme Vakfı Yayın No:83. 2. Baskı. 1996.
  • Yanagihara N, Utsunomiya K, Cheah TB, Hirano H, Kajiwara K, Hara K, Nakamura E, Toyohira Y, Uezono Y, Ueno S, Izumi F. Characterization and functional role of leptin receptor in bovine adrenal medullary cells. Biochem. Pharmac. 2000; 59: 1141-1145.
  • Yiş U, Öztürk Y, Büyükgebiz B. Ghrelin: enerji metabolizmasının düzenlenmesinde yeni bir hormon. Çocuk Sağlığı ve Hastalıkları Dergisi. 2005; 48: 196-201.
  • Zabrocka L., Klimek J., Swierczynski J. Evidence that triiodothyronine decreases rat serum leptin concentration by down-regulation of leptin gene expression in white adipose tissue. Life Science. 2006; 79: 1114-1120.
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature (Lond.). 1994; 372: 425-432.

The Effects of Leptin on Other Hormones

Year 2015, Volume: 8 Issue: 1, 75 - 83, 01.06.2015

Abstract

Our understanding of the effects of leptin have stemmed mainly from animal studies, which continue to leave important clues of its roles in physiology, metabolism, and cell signaling. Since its discovery, leptin has been linked to various pathways with some metabolites and hormones. Leptin influences hypothalamic-pituitary function, particularly during the adaptation to caloric restriction and starvation. The fall in leptin is a signal to reduce energy expenditure by limiting thyroid hormone, growth hormone, and gonadal hormone secretion and by increasing cortisol release. The leptin signal is primarily mediated through receptors located within hypothalamic nuclei, although some effects may occur by leptin binding directly to cells of the anterior pituitary. Leptin may also regulate thyroid and adrenal gland function through leptin receptors located on these tissues. Finally, leptin has direct effects on adipose tissue function, which can alter secretion of various adipokines from the tissue. Thus leptin, as a signal of metabolic, has significant regulatory effects on many endocrine systems.

References

  • Ahima RS, Flier JS. Leptin. Annu.Rev.Physiol. 2000; 62: 413-437.
  • Alikaşifoğlu A. Enerji metabolizmasının düzenlenmesinde hormonların ve nörotransmitterlerin rolü. Katkı Pediatri Dergisi. 2000; 21(4): 492-499.
  • Andrews J.F. Leptin: energy regulation and beyond to a hormone with pan-physiological function. Proc Nutr Soc. 1998; 57: 409-411.
  • Aslan K., Serdar Z., Tokullugil A. Multifonksiyonel Hormon: Leptin. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2004; 30(2): 113-118.
  • Bocquier F, Bommet M, Faulconnier Y, Guerre-Millo M, Martin P, Chilliard Y. Effects of photoperiod and feeding level on perirenal adipose tissue metabolic activity and leptin synthesis in the ovariectomized ewe. Reprod Nutr Develop. 1998; 38: 489-498.
  • Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Diabetes. 1997; 46: 1235-1238.
  • Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 1996; 84: 491-495.
  • Chilliard Y, Bonnet M, Delavaud C, Faulconniera Y, Lerouxb C, Djianec J, Bocquierd F. Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Dom.Anim.Endocrinol. 2001; 21: 271-295.
  • Correia ML, Morgan DA, Sivitz WI, Mark AL, Haynes WG. Leptin acts in the central nervous system to produce dosedependent changes in arterial pressure. Hypertension. 2001; 37: 936-942.
  • Dagogo JS, Fanelli C, Paramore D, Brothers J, Landt M. Plasma leptin and insulin relationships in obese andnonobese humans (abstract). Diabetes. 1996; 45: 695-698.
  • De Boer H, Blok G-J, van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews. 1995; 16: 63-86.
  • Delavaud C, Ferlay A, Faulconnier Y, Bocquier F, Kann G, Chilliard Y. Plasma leptin concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J.Anim. Sci. 2002; 80: 1317-1328.
  • Emilsson V, Liu Y, Cawthorne MA, Morton NM. Devenport M. Expression and functional leptin receptor mRNA in pancreaticislets and direct inhibitory action of leptin on insulin secretion. Diabetes. 1997; 46: 313-316.
  • Ersoy E, Bayşu N. Biyokimya. Ankara Ünivesitesi Veteriner Fakültesi Yayınları No: 408. Ders Kitabı. 1986. S: 553-559.
  • Eryavuz A, Avci G, Celik HA, Kucukkurt I. Plasma leptin, insulin, glucose, and urea concentrations throughout lactation in dairy cows. Bull Vet Inst Pulawy. 2008; 52(3): 381-385.
  • Eryavuz A, Avci G, Kucukkurt I, Fidan AF. Comparison of plasma leptin, ınsulin and thyroid hormone concentrations and some biochemical parameters between fat-tailed and thin-tailed sheep breeds. Revue de Médecine Vétérinaire. 2007; 158(5): 244-249.
  • Escobar-Morreale HF, Escobar del Rey F, Morreale de Escobar G. Thyroid hormones influence serum leptin concentrations in the rat. Endocrinology. 1997; 138, 4485–4488.
  • Fain J, Coronel E, Beauchamp M, Bahouth S. Expression of leptin and beta 3-adrenergic receptors in rat adipose tissue in altered thyroid states. Biochemical Journal. 1997; 322: 145–150.
  • Fei H, Okano HJ. Li C, Lee GH, Zhao C Darnell R, Friedman JM. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. U.S.A. 1997; 94 (13): 7001-7005.
  • Florkowski CM, Collier GR, Zimmet PZ, Livesey JH, Espiner EA, Donald RA. Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol. 1996; 45: 769- 773.
  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mamals. Nature. 1998; 395: 763-770.
  • Gualillo O, Lago F, García M, Menéndez C, Señarís R, Casanueva FF, Diéguez C. Prolactin stimulates leptin secretion by rat white adipose tissue. Endocrinology; 1999; 140: 5149- 5153.
  • Güven Ş, El-Bershawi A, Sonnenberg GE, Wilson CR, Hoffmann RG, Krakower GR, Kissebah AH. Diabetes. 1999; 48: 347-352.
  • Haris RB. Acute and chronic effects of leptin on glucose utilization in lean mice. Biochem. Biophys. Res. Commun. 1998; 245 (2): 502-509.
  • Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E. et al. Augmented growth hormone secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. Journal of Clinical Endocrinology and Metabolism. 1992; 74: 757-765.
  • Harvey J, Mc Kenna F, Herson PS, Spanswick D, Ashford LJ. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J physiol. 1997; 504: 527-535.
  • Hekimoğlu A. Metabolik Sendromda Adiponektin. Harran Üniversitesi Tıp Fakültesi Dergisi. 2007; 4(2): 61-68.
  • Houseknecht KL, Baile CA, Matteri RL, Spurlock ME. The biology of leptin: a review. J.Anim.Sci. 1998; 76: 1405-1420.
  • Houseknecht KL, Portocarrero CP, Ji S, Lemenager R, Spurlock ME. Growth hormone regulates leptin gene expression in bovine adipose IGF-1 expression. J Endocrinol. 2000; 164: 51-57.
  • Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, Fujimiya M. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004; 18: 439-456.
  • Iraklinaou S, Melidonis A, Tournis S, Konstandelou E, Tsatsoulis A, Elissaf M, Sideris D. Postprandial leptinresponses after an oral fat tolerance test. Diabetes Care. 2001; 24: 1299-1300.
  • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes. 2001; 50: 2438-2443.
  • Kauter K, Ball M, Kearney P, Tellam R, McFarlane JR. Adrenaline, insulin and glucagon do not have acute effects on plasma leptin levels in sheep: development and characterisation of an ovine leptin ELISA. J. Endocrinol. 2000; 166: 127-135.
  • Kielar D, Clark JS, Ciechanowicz A, Kurzawski G, Sulikowski T, Naruszewicz M. Leptin receptor isoforms expressed in human adipose tissue. Metabolism. 1998; 47: 844-847.
  • Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Hanry R, Mudaliar SR, Olefsky J, Caro JF. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro (abstract). Diabetes. 2001; 45: 699-701.
  • Kucukkurt I, Akbel E, Karabag F, Ince S. The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicology and Industrial Health. Doi: 10.1177/0748233712469648. 2013.(Baskıda).
  • Kucukkurt I, Dundar Y. Effects of dietary Yucca schidigera supplementation on plasma leptin, insulin, iodated thyroid hormones and some biochemical parameters in rats. Revue de Medecine Veterinaire. 2013; 164(7): 362-367.
  • Küçükkurt İ. Diyete katılan farklı miktarlardaki Yucca schidigera tozunun sıçanlarda plazma leptin, insulin ve tiroid hormonları ile bazı biyokimyasal parametrelere etkilerinin araştırılması. Doktora Tezi. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü, Afyonkarahisar, 2007.
  • Lengyel AM. Novel mechanisms of growth hormone regulation: growth hormone releasing peptides and ghrelin. Braz J Med Biol Res. 2006; 39: 1003-1011.
  • Lin Y, Matsumura K, Fukuhara M, Kagiyama S, Fujii K, Iida M. Grelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension. 2004; 43(5): 977-982.
  • Lönnqvist F, Wennlund A, Arner P. Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obesity. 1997; 21: 255-260.
  • Madej T, Boguski MS, Bryant SH. Threading analysis suggest that the obese gene product may be a helical cytokine. FEBS Letters. 1995; 373: 13-18.
  • Malmström R, Taskinen MR, Karonen SL, Jarvinen HY. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia. 1996; 39: 993-996.
  • Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. International J. of Obesity. 2002; 26: 1407-1433.
  • Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol. 2002; 147: 173-180.
  • Medina-Gomez G, Rosa-Maria C, Maria-Jesus O. T3 and Triac inhibit leptin secretion and expression in brown and white rat adipocytes. Biochimica et Biophysica Acta. 2004; 1682: 38-47.
  • Mercer JG, Moar KM, Findlay PA, Hoggard N, Adam CL. Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem. Regul. Pept. 1998; 75-76: 271-278.
  • Nagatani S, Zeng Y, Keisler DH, Foster DL, Jaffe CA. Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the shepp. Endocrinology. 2000; 141: 3965-3975.
  • Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K. Hemodynamic and hormonal effects of human grelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol. 2001; 280(5): 1483-1487.
  • Ren MQ, Wegner J, Bellmann O, Brockmann GA, Schneider F, Teuscher F, Ender K. Comparing mRNA levels of genes encoding leptin, leptin receptor, and lipoprotein lipase between dairy and beef cattle. Dom.Anim.Endocrinol. 2002; 23: 371-381.
  • Roh S, Clarke IJ, Xu R, Goding JW, Loneragan K, Chen C. The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland. Neu-roendocrinology. 1998; 68(6): 361-364.
  • Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature. 1995; 377: 527-529.
  • Scacchi M., Pincelli A., Cavagnini F. Growth hormone in obesity. International Journal of Obesity. 1999; 23: 260-271.
  • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HFA.. Novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem, 1995; 270: 26746-26749.
  • Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab. 1999; 84: 670-676.
  • Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem. 1996; 271: 5301-5304.
  • Stenvinkel P. Leptin. In: Shaul G. Massry, Richard J. Glassock (ed). Textbook of Nephrology, Fourth Edition, Lippincott Williams&Wilkins, Philadelphia. 2001; pp.1367- 1371.
  • Tallman D.L., Taylor C.G. Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2. Can J Physiol Pharmacol. 1999; 77: 919-933.
  • Tartaglia L A, Demski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995; 83: 1263-1271.
  • Towhidi A, Rostami F, Khazali H, Ahadi AH. The effect of energy intake level, body condition score, and leptin on ovulation rate in fat-tailed ewes. Proceedings of the British Society of Animal Science. 2002; 80.
  • Trayhurn P, Duncan JS, Rayner DV. Research communication acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system. Biochem. J. 1995; 311: 729-733.
  • Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000; 407: 908- 913.
  • Viengchareun S, Zennaro MC, Pascual-Le Tallec L, Lombes M. Brown adipocytes are novel sites ofexpression and regulation of adiponectin and resistin. FEBS Lett. 2002; 532: 345-350.
  • Wallace A.M. Measurement of leptin and leptin binding in the human circulation. Ann Clin. Biochem. 2000; 37 (3): 244-252.
  • Wauters M., Considine R.V., Van Gaal L.F. Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol. 2000; 143: 293-311.
  • Williams GL, Amstalden M, Garcia MR, Stanko RL, Nizielski SE, Morrison CD, Keisler DH. Leptin and its role in the central regulation of reproduction in cattle. Dom.Anim.Endocrinol. 2002; 23: 339-349.
  • Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD. Daily metatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology. 2000; 141: 487-497.
  • Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR. Ghrelin causes hyperphagia and obesity in rats. Diabetes. 2001; 50: 2540-2547.
  • Yaman K. Fizyoloji. Uludağ Üniversitesi Güçlendirme Vakfı Yayın No:83. 2. Baskı. 1996.
  • Yanagihara N, Utsunomiya K, Cheah TB, Hirano H, Kajiwara K, Hara K, Nakamura E, Toyohira Y, Uezono Y, Ueno S, Izumi F. Characterization and functional role of leptin receptor in bovine adrenal medullary cells. Biochem. Pharmac. 2000; 59: 1141-1145.
  • Yiş U, Öztürk Y, Büyükgebiz B. Ghrelin: enerji metabolizmasının düzenlenmesinde yeni bir hormon. Çocuk Sağlığı ve Hastalıkları Dergisi. 2005; 48: 196-201.
  • Zabrocka L., Klimek J., Swierczynski J. Evidence that triiodothyronine decreases rat serum leptin concentration by down-regulation of leptin gene expression in white adipose tissue. Life Science. 2006; 79: 1114-1120.
  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature (Lond.). 1994; 372: 425-432.
There are 73 citations in total.

Details

Journal Section REVIEW
Authors

İsmail Küçükkurt

Publication Date June 1, 2015
Acceptance Date February 13, 2015
Published in Issue Year 2015 Volume: 8 Issue: 1

Cite

APA Küçükkurt, İ. (2015). The Effects of Leptin on Other Hormones. Kocatepe Veterinary Journal, 8(1), 75-83.
AMA Küçükkurt İ. The Effects of Leptin on Other Hormones. kvj. January 2015;8(1):75-83.
Chicago Küçükkurt, İsmail. “The Effects of Leptin on Other Hormones”. Kocatepe Veterinary Journal 8, no. 1 (January 2015): 75-83.
EndNote Küçükkurt İ (January 1, 2015) The Effects of Leptin on Other Hormones. Kocatepe Veterinary Journal 8 1 75–83.
IEEE İ. Küçükkurt, “The Effects of Leptin on Other Hormones”, kvj, vol. 8, no. 1, pp. 75–83, 2015.
ISNAD Küçükkurt, İsmail. “The Effects of Leptin on Other Hormones”. Kocatepe Veterinary Journal 8/1 (January 2015), 75-83.
JAMA Küçükkurt İ. The Effects of Leptin on Other Hormones. kvj. 2015;8:75–83.
MLA Küçükkurt, İsmail. “The Effects of Leptin on Other Hormones”. Kocatepe Veterinary Journal, vol. 8, no. 1, 2015, pp. 75-83.
Vancouver Küçükkurt İ. The Effects of Leptin on Other Hormones. kvj. 2015;8(1):75-83.

13520    13521       13522   1352314104

14105         14106        14107       14108