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Yüksek Nitratlı Diyetle Beslenen Ankara Keçilerinde Tiroid Hormonları Üzerine Kükürt İlavesinin Etkileri

Year 2018, Volume 11, Issue 3, 203 - 207, 01.09.2018
https://doi.org/10.30607/kvj.397352

Abstract

Bu çalışma, yüksek diyetli nitrat alımı ve inorganik kükürt ilavesinin Ankara keçilerindeki tiroid hormonlarına etkisini belirlemek amacıyla yapıldı. Çalışmada, yaklaşık 14 aylık yaştaki 18 erkek Ankara keçisi 3 gruba bölündü: kontrol grup bazal diyetle beslendi, nitrat grubu 1500 ppm nitrat  ilave edilen bazal diyetle beslendi ve nitrat+kükürt grubu 1500 ppm nitrat ve %1.8 sodyum sülfat ilave edilen bazal diyetle beslendi. Çalışmanın 45., 90., 135. ve 180. günlerinde serum örneklerinde tiroid uyarıcı hormon (TSH), total ve serbest triiyodotironin (TT3 veFT3) ve tetraiyodotironin (TT4 ve FT4) düzeyleri ölçüldü. 180. günde, TT4 hariç, serum TSH, total ve serbest T3 ve serbest T4 konsantrasyonları nitrat+kükürt grubunda  kontrol ve nitrat grubundan daha yüksekti (P<0.01). Bu çalışma, Ankara keçilerinin tiroid hormonları dikkate alındığında 1500 ppm nitrat içeren bir beslemeyi tolere edebileceğini ve inorganik kükürdün doza bağlı olarak tiroid hormonları üzerine yüksek nitratlı diyetin olumsuz etkilerini hafifletmek için  doğal bir kaynak görevi görebileceğini önermektedir.

References

  • Bartik M, Piskac A. Intoxication of animals by inorganic poisons. In, Bartic M. and Piskac A. (eds): Veterinary Toxicology, Elseiver Scientific Publishing Company, 47-59, Amsterdam-Oxford-Newyork, 1981.
  • Bruning-Fann CS, Kaneene JB. The effects of nitrate, nitrite and N-nitroso compounds on human health: A review. Vet Hum Toxicol. 1993; 35: 521-538.
  • Burrows GE, Horn GW, Mcnew RW, Croy LI, Keeton RD, Kyle J. The prophylactic effect of corn supplementation on experimental nitrate intoxication in cattle. J Anim Sci. 1989; 64: 1682-1989.
  • Carneiro H, Puchala R, Owens FN, Sahlu T, Qi K, Goetsch AL. Effects of dietary sulfur level on amino acid concentrationsin ruminal bacteria of goats. Small Rum Res. 2000; 37: 151-157.
  • Cheng KJ, Philippe RC, Majak W. Identification of rumen bacteria that anaerobically degrade nitrite. Can J Microbiol. 1988; 34: 1099-1102.
  • Chow CK, Hong CB. Vitamin E and selenium and toxicity of nitrite and nitrate. Toxicology. 2002; 180: 195-207.
  • Eskiocak S, Dundar C, Basoglu T, Altaner S. The effects of taking chronic nitrate by drinking water on thyroid functions and morphology. Clin Exp Med. 2005; 5: 66-71.
  • Georgiev P, Nikolov I, Simeonov SP, Iordanova V. Dynamics of thyroid hormones and hematological and biochemical indices in chronic nitrate poisoning in sheep. Vet Med Nauki.1987, 24; 58-62.
  • Jahreis G, Hesse V, Schone F, Hennig A, Gruhn K. Effect of chronic dietary nitrate and different iodine supply on porcine thyroid function, somatomedin-C-level and growth. Exp Clin Endocrinol. 1986; 88: 242-248.
  • Jordao CP, Pereira MG, Bellato CR, Pereira JL, Matos AT. Assessment of water systems for contaminants from domestic and industrial sewages. Environ Monit Assess. 2002; 79: 75-100.
  • Kaya S, Bilgili A, Liman BC, Dogan A. Çeşitli yem ve yem hammaddelerinden nitrat ve nitrit düzeyleri üzerine bir araştırma. A Ü Vet Fak Derg. 1989; 36: 455-466.
  • Keçeci T, Keskin E. Zinc supplementation decreases total thyroid hormone concentration in small ruminants. Acta Veterinaria Hungarica. 2001; 50: 93-100.
  • Kostogry RB, Paweł M, Pisulewski PM, Pecio A, Filipiak-Florkiewicz A. Goitrogenic effects of allyl isothiocyanate, nitrate and nitrite in rats and alleviating properties of iodine and selenium supplements rumen micro-organisms. Br J Nutr. 1989; 61: 741-748.
  • Mensinga TT, Speijers GJ, Meulenbelt J. Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev. 2003; 22: 41-51.
  • National Research Council. Nutrient requirements of goats: Angora, dairy and meat goats in temperate and tropical countries. Washington, DC. USA: The National Academies Press, 1981. https://doi.org/10.17226/30
  • Nlend MC, Cauvi D11, Venot N, Chabaud O. Sulfated tyrosines of thyroglobulin are ınvolved in thyroid hormone synthesis. Biochem Biophys Res Commun. 1999; 262:193-197.
  • Ozdemir M, Eryavuz A, Avci G, Birdane YO, Kucukkurt I. Effects of supplementation of inorganic sulfur on some biochemical parameters in Angora goat’s diet containing high nitrate levels. Turk J Vet Anim Sci. 2014; 38: 526-533.
  • Pirincci I, Acet A. Yemlerde nitrat ve nitrit düzeyleriyle ilgili çalişmalar. A Ü Vet Fak Derg.1984; 31: 41-52.
  • Puchala R, Prieto I, Banskalieva V, Goetsch AL, Lachica M, Sahlu T. Effects of bovine somatotropin and thyroid hormone status on hormone levels, body weight gain, and mohair fiber growth of Angora goats. J Anim Sci. 2001; 79: 2913-2919.
  • Simon C, Bosted H, Adams W. Juvenile goiter in a goat herd in northwest Germany. Schweiz Arch Tierheilkd. 2000;142: 339-347.
  • Takahashi J, Ikeda M, Matsuoka S, Fujita H. Prophylactic effect of L-cysteine to acute and subclinical nitrate toxicity in sheep. Anim. Feed Sc. Technol.1998; 74: 273-280.
  • Takahashi J, Johchi N, Fujita H. Inhibitory effects of sulfurcompounds, copper and tungsten on nitrate reduction by mixed rumen micro-organisms. Br J Nutr. 1989; 61: 741-748.

Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet

Year 2018, Volume 11, Issue 3, 203 - 207, 01.09.2018
https://doi.org/10.30607/kvj.397352

Abstract

This study was to aimed for determination the effect of high dietary nitrate intake and inorganic sulphur supplementation on thyroids hormones in Angora goats. In this study, eighteen male Angora goats aged 14 months were  divided into three groups (n = 6):   control group fed with a basal diet, nitrate group fed with a basal diet supplemented with 1500 ppm nitrate, and nitrate + sulfur group fed with a basal diet supplemented with 1500 ppm nitrate and 1.8% sodium sulfate. On days 45, 90, 135, and 180 of the study, the concentrations of the thyroid-stimulating hormone (TSH), total and free triiodothyronine (TT3 and FT3), and tetraiodothyronine (TT4 and FT4) were measured in the serum samples. On day 180, except for TT4, the serum TSH and total and free T3 and free T4 concentrations were higher (P<0.05) in the nitrate + sulfur group than in the control and nitrate groups. This study suggested that Angora goats could tolerate a feed containing 1500 ppm nitrate with respect to the thyroid hormones, and inorganic sulfur might serve as a natural source for alleviating the negative effects of the high-nitrate diet on the thyroid gland in a dose-dependent manner. 

References

  • Bartik M, Piskac A. Intoxication of animals by inorganic poisons. In, Bartic M. and Piskac A. (eds): Veterinary Toxicology, Elseiver Scientific Publishing Company, 47-59, Amsterdam-Oxford-Newyork, 1981.
  • Bruning-Fann CS, Kaneene JB. The effects of nitrate, nitrite and N-nitroso compounds on human health: A review. Vet Hum Toxicol. 1993; 35: 521-538.
  • Burrows GE, Horn GW, Mcnew RW, Croy LI, Keeton RD, Kyle J. The prophylactic effect of corn supplementation on experimental nitrate intoxication in cattle. J Anim Sci. 1989; 64: 1682-1989.
  • Carneiro H, Puchala R, Owens FN, Sahlu T, Qi K, Goetsch AL. Effects of dietary sulfur level on amino acid concentrationsin ruminal bacteria of goats. Small Rum Res. 2000; 37: 151-157.
  • Cheng KJ, Philippe RC, Majak W. Identification of rumen bacteria that anaerobically degrade nitrite. Can J Microbiol. 1988; 34: 1099-1102.
  • Chow CK, Hong CB. Vitamin E and selenium and toxicity of nitrite and nitrate. Toxicology. 2002; 180: 195-207.
  • Eskiocak S, Dundar C, Basoglu T, Altaner S. The effects of taking chronic nitrate by drinking water on thyroid functions and morphology. Clin Exp Med. 2005; 5: 66-71.
  • Georgiev P, Nikolov I, Simeonov SP, Iordanova V. Dynamics of thyroid hormones and hematological and biochemical indices in chronic nitrate poisoning in sheep. Vet Med Nauki.1987, 24; 58-62.
  • Jahreis G, Hesse V, Schone F, Hennig A, Gruhn K. Effect of chronic dietary nitrate and different iodine supply on porcine thyroid function, somatomedin-C-level and growth. Exp Clin Endocrinol. 1986; 88: 242-248.
  • Jordao CP, Pereira MG, Bellato CR, Pereira JL, Matos AT. Assessment of water systems for contaminants from domestic and industrial sewages. Environ Monit Assess. 2002; 79: 75-100.
  • Kaya S, Bilgili A, Liman BC, Dogan A. Çeşitli yem ve yem hammaddelerinden nitrat ve nitrit düzeyleri üzerine bir araştırma. A Ü Vet Fak Derg. 1989; 36: 455-466.
  • Keçeci T, Keskin E. Zinc supplementation decreases total thyroid hormone concentration in small ruminants. Acta Veterinaria Hungarica. 2001; 50: 93-100.
  • Kostogry RB, Paweł M, Pisulewski PM, Pecio A, Filipiak-Florkiewicz A. Goitrogenic effects of allyl isothiocyanate, nitrate and nitrite in rats and alleviating properties of iodine and selenium supplements rumen micro-organisms. Br J Nutr. 1989; 61: 741-748.
  • Mensinga TT, Speijers GJ, Meulenbelt J. Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev. 2003; 22: 41-51.
  • National Research Council. Nutrient requirements of goats: Angora, dairy and meat goats in temperate and tropical countries. Washington, DC. USA: The National Academies Press, 1981. https://doi.org/10.17226/30
  • Nlend MC, Cauvi D11, Venot N, Chabaud O. Sulfated tyrosines of thyroglobulin are ınvolved in thyroid hormone synthesis. Biochem Biophys Res Commun. 1999; 262:193-197.
  • Ozdemir M, Eryavuz A, Avci G, Birdane YO, Kucukkurt I. Effects of supplementation of inorganic sulfur on some biochemical parameters in Angora goat’s diet containing high nitrate levels. Turk J Vet Anim Sci. 2014; 38: 526-533.
  • Pirincci I, Acet A. Yemlerde nitrat ve nitrit düzeyleriyle ilgili çalişmalar. A Ü Vet Fak Derg.1984; 31: 41-52.
  • Puchala R, Prieto I, Banskalieva V, Goetsch AL, Lachica M, Sahlu T. Effects of bovine somatotropin and thyroid hormone status on hormone levels, body weight gain, and mohair fiber growth of Angora goats. J Anim Sci. 2001; 79: 2913-2919.
  • Simon C, Bosted H, Adams W. Juvenile goiter in a goat herd in northwest Germany. Schweiz Arch Tierheilkd. 2000;142: 339-347.
  • Takahashi J, Ikeda M, Matsuoka S, Fujita H. Prophylactic effect of L-cysteine to acute and subclinical nitrate toxicity in sheep. Anim. Feed Sc. Technol.1998; 74: 273-280.
  • Takahashi J, Johchi N, Fujita H. Inhibitory effects of sulfurcompounds, copper and tungsten on nitrate reduction by mixed rumen micro-organisms. Br J Nutr. 1989; 61: 741-748.

Details

Primary Language English
Subjects Science
Journal Section RESEARCH ARTICLE
Authors

Gülcan AVCI (Primary Author)
Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University
0000-0001-8767-4507
Türkiye


Yavuz Osman BİRDANE
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Afyon Kocatepe University
Türkiye


Mehmet ÖZDEMİR This is me
Faculty of Health Sciences, Karabuk University, Karabuk
Türkiye


İsmail KÜCÜKKURT
Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University,
Türkiye


Abdullah ERYAVUZ
Department of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe University
0000-0001-8602-2400
Türkiye

Publication Date September 1, 2018
Published in Issue Year 2018, Volume 11, Issue 3

Cite

Bibtex @research article { kvj397352, journal = {Kocatepe Veterinary Journal}, issn = {1308-1594}, eissn = {2147-6853}, address = {}, publisher = {Afyon Kocatepe University}, year = {2018}, volume = {11}, pages = {203 - 207}, doi = {10.30607/kvj.397352}, title = {Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet}, key = {cite}, author = {Avcı, Gülcan and Birdane, Yavuz Osman and Özdemir, Mehmet and Kücükkurt, İsmail and Eryavuz, Abdullah} }
APA Avcı, G. , Birdane, Y. O. , Özdemir, M. , Kücükkurt, İ. & Eryavuz, A. (2018). Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet . Kocatepe Veterinary Journal , 11 (3) , 203-207 . DOI: 10.30607/kvj.397352
MLA Avcı, G. , Birdane, Y. O. , Özdemir, M. , Kücükkurt, İ. , Eryavuz, A. "Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet" . Kocatepe Veterinary Journal 11 (2018 ): 203-207 <https://dergipark.org.tr/en/pub/kvj/issue/37070/397352>
Chicago Avcı, G. , Birdane, Y. O. , Özdemir, M. , Kücükkurt, İ. , Eryavuz, A. "Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet". Kocatepe Veterinary Journal 11 (2018 ): 203-207
RIS TY - JOUR T1 - Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet AU - Gülcan Avcı , Yavuz Osman Birdane , Mehmet Özdemir , İsmail Kücükkurt , Abdullah Eryavuz Y1 - 2018 PY - 2018 N1 - doi: 10.30607/kvj.397352 DO - 10.30607/kvj.397352 T2 - Kocatepe Veterinary Journal JF - Journal JO - JOR SP - 203 EP - 207 VL - 11 IS - 3 SN - 1308-1594-2147-6853 M3 - doi: 10.30607/kvj.397352 UR - https://doi.org/10.30607/kvj.397352 Y2 - 2018 ER -
EndNote %0 Kocatepe Veterinary Journal Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet %A Gülcan Avcı , Yavuz Osman Birdane , Mehmet Özdemir , İsmail Kücükkurt , Abdullah Eryavuz %T Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet %D 2018 %J Kocatepe Veterinary Journal %P 1308-1594-2147-6853 %V 11 %N 3 %R doi: 10.30607/kvj.397352 %U 10.30607/kvj.397352
ISNAD Avcı, Gülcan , Birdane, Yavuz Osman , Özdemir, Mehmet , Kücükkurt, İsmail , Eryavuz, Abdullah . "Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet". Kocatepe Veterinary Journal 11 / 3 (September 2018): 203-207 . https://doi.org/10.30607/kvj.397352
AMA Avcı G. , Birdane Y. O. , Özdemir M. , Kücükkurt İ. , Eryavuz A. Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet. Kocatepe Veterinary Journal. 2018; 11(3): 203-207.
Vancouver Avcı G. , Birdane Y. O. , Özdemir M. , Kücükkurt İ. , Eryavuz A. Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet. Kocatepe Veterinary Journal. 2018; 11(3): 203-207.
IEEE G. Avcı , Y. O. Birdane , M. Özdemir , İ. Kücükkurt and A. Eryavuz , "Effects of Sulfur Supplementation on Thyroid Hormones in Angora Goats Fed With a High-Nitrate Diet", Kocatepe Veterinary Journal, vol. 11, no. 3, pp. 203-207, Sep. 2018, doi:10.30607/kvj.397352

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