Anthelmintic Resistance in Farm Animals

Year 2018, Volume: 11 Issue: 3, 322 - 330, 01.09.2018

Mahmut Sinan Erez Esma Kozan

https://doi.org/10.30607/kvj.429795

Cited By: 1

Abstract

Anthelmintic
resistance means that developing genetically transmitted lack of susceptibility
to an anthelmintic which is previously known to be susceptible to a parasite
population. Anthelmintic resistance has an increasing importance in recent
years. The anthelmintic resistance which is developed especially due to use of
unconscious anthelmintics also brings with it economic problems. Investigations
have shown that resistance has developed to anthelmintics in a short period of
time after launch to the market and even in some countries, several sheep and
goat farms have been closed due to anthelmintic resistance. For this reason,
especially in livestock breeding; The development of resistance should not be
overlooked while planning of treatment and control programs and choosing
anthelmintics. In this review, resistance mechanisms which is developed to
anthelmentic drugs, resistance detection methods and anthelmentic resistance
status of livestock in Turkey were evaluated.

Keywords

Anthelmintics, Cattle, Goat, Resistance, Sheep

Çiftlik Hayvanlarında Antelmentik Direnç

Abstract

Bir parazit
populasyonunun daha önce duyarlı olduğu bir antelmentiğe karşı gelişen ve
genetik yolla aktarılan duyarlılık kaybı olarak değerlendirilen antelmentik
direnç, son yıllarda giderek artan bir öneme sahiptir. Özellikle bilinçsiz ilaç
kullanımına bağlı olarak gelişen antelmentik direnç ekonomik problemleri de
beraberinde getirmektedir. Yapılan araştırmalar bazı ilaçların piyasaya
sürümünü takiben kısa süreler içinde ilaca karşı bir direnç geliştiğini hatta
bazı ülkelerde sadece direnç gelişmine bağlı olarak çiftliklerin kapatıldığı
göstermektedir. Bu nedenle özellikle çiftlik hayvanları yetişrtiriciliğinde;
antelmentik kullanılırken veya helmint enfeksiyonlarının tedavi ve kontrol
programları planlanırken direnç gelişimi göz ardı edilmemeilidir. Bu derlemede
antelmentik ilaçlara gelişen direnç mekanizmaları ve direnç tespit yöntemleri
ile Türkiye’de çiftlik hayvanlarında belirlenen antelmentik direnç hakkında
özlü bilgi verilmiştir.

Keywords

Koyun, Antelmentikler, Direnç, Keçi, Sığır

References

• Abbott KA, Taylor MA, Stubbings LA. SCOPS–Sustainable Worm Control Strategies for Sheep 4th Edition: A Technical Manual for Veterinary Surgeons and Advisers. Context Publishing, (2012).
• Bartos M, Rayes D, Bouzat C. Molecular determinants of pyrantel selectivity in nicotinic receptors. Molecular pharmacology, (2006); 70(4), 1307-1318.
• Blackhall WJ, Pouliot JF, Prichard RK, Beech RN. Haemonchus contortus: selection at a glutamate-gated chloride channel gene in ivermectin-and moxidectin-selected strains. Experimental parasitology, (1998); 90(1), 42-48.
• Blackhall WJ, Prichard RK, Beech RN. Selection at a γ-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. Molecular and biochemical parasitology, (2003); 131(2), 137-145.
• Boulin T, Gielen M, Richmond JE, Williams DC, Paoletti P, Bessereau JL. Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor. Proceedings of the National Academy of Sciences, (2008); 105(47), 18590-18595.
• Cırak, VY, Kar S, Girişgin O. İvermektin ve pirantele karşı at Strongylidae’lerinde antelmentik direnç araştırılması ve Parascaris equorum’da makrosiklik lakton direnci. Türkiye Parasitol Derg, (2010); 34, 35-39.
• Cintra MCR, Teixeira VN, Nascimento LV, Sotomaior CS. Lack of efficacy of monepantel against Trichostrongylus colubriformis in sheep in Brazil. Veterinary parasitology, (2016); 216, 4-6.
• Cirak VY, Güleğen E, Bauer C. Benzimidazole resistance in cyathostomin populations on horse farms in western Anatolia, Turkey. Parasitology Research, (2004); 93(5), 392-395.
• Coles GC, Bauer C, Borgsteede FHM, Geerts S, Klei TR, Taylor MA, Waller PJ. World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Veterinary parasitology, (1992); 44(1-2), 35-44.
• Coles GC, Jackson F, Pomroy WE, Prichard RK, von Samson-Himmelstjerna G, Silvestre A, Taylor MA, Vercruysse J. The detection of anthelmintic resistance in nematodes of veterinary importance. Veterinary parasitology, (2006); 136(3), 167-185.
• Coles GC. Anthelmintic resistance–looking to the future: a UK perspective. Research in veterinary science, (2005); 78(2), 99-108.
• Cook A, Aptel N, Portillo V, Siney E, Sihota R, Holden-Dye L, Wolstenholme A. Caenorhabditis elegans ivermectin receptors regulate locomotor behaviour and are functional orthologues of Haemonchus contortus receptors. Molecular and biochemical parasitology, (2006); 147(1), 118-125.
• De Graef J. Detection and mechanisms of macrocyclic lactone resistance in the bovine nematode Cooperia oncophora, (2013).
• De Graef, J., Claerebout, E., & Geldhof, P. (2013). Anthelmintic resistance of gastrointestinal cattle nematodes. Vlaams Diergeneeskundig Tijdschrift, 82(3), 113-123.
• Demeler J, Krücken J, Al Gusbi S, Ramünke S, De Graef J, Kerboeuf D, Geldhof P, Pomroy WE, von Samson-Himmelstjerna G. Potential contribution of P-glycoproteins to macrocyclic lactone resistance in the cattle parasitic nematode Cooperia oncophora. Molecular and biochemical parasitology, (2013); 188(1), 10-19.
• Demeler J, Küttler U, von Samson-Himmelstjerna G. Adaptation and evaluation of three different in vitro tests for the detection of resistance to anthelmintics in gastro intestinal nematodes of cattle. Veterinary parasitology, (2010); 170(1), 61-70.
• Dent JA, Smith MM, Vassilatis DK, Avery L. The genetics of ivermectin resistance in Caenorhabditis elegans. Proceedings of the National Academy of Sciences, (2000); 97(6), 2674-2679.
• Dicker AJ, Nisbet AJ, Skuce PJ. Gene expression changes in a P-glycoprotein (Tci-pgp-9) putatively associated with ivermectin resistance in Teladorsagia circumcincta. International journal for parasitology, (2011); 41(9), 935-942.
• Dicker AJ. Comparative gene expression studies of anthelmintic resistance in the parasitic nematode, Teladorsagia circumcincta (Doctoral dissertation, University of Glasgow), 2010.
• Fleming JT, Squire MD, Barnes TM, Tornoe C, Matsuda K, Ahnn J, Fire A, Sulston JE, Barnard EA, Sattelle DB, Lewis JA. (1997). Caenorhabditis elegans Levamisole Resistance Geneslev-1, unc-29, and unc-38 Encode Functional Nicotinic Acetylcholine Receptor Subunits. Journal of Neuroscience, 17(15), 5843-5857.
• Fleming SA, Craig T, Kaplan RM, Miller JE, Navarre C, Rings M. Anthelmintic resistance of gastrointestinal parasites in small ruminants. Journal of veterinary internal medicine, (2006); 20(2), 435-444.
• Geary TG. Ivermectin 20 years on: maturation of a wonder drug. Trends in parasitology, (2005); 21(11), 530-532.
• Ghisi M, Kaminsky R, Mäser P. Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes. Veterinary parasitology, (2007); 144(3), 313-320.
• Gilleard JS. Understanding anthelmintic resistance: the need for genomics and genetics. International journal for parasitology, (2006); 36(12), 1227-1239.
• Hodgkinson JE, Clark HJ, Kaplan RM, Lake SL, Matthews JB. The role of polymorphisms at β tubulin isotype 1 codons 167 and 200 in benzimidazole resistance in cyathostomins. International journal for parasitology, (2008); 38(10), 1149-1160.
• Jabbar A, Iqbal Z, Kerboeuf D, Muhammad G, Khan MN, Afaq M. Anthelmintic resistance: the state of play revisited. Life sciences, (2006); 79(26), 2413-2431.
• Kaplan RM. Drug resistance in nematodes of veterinary importance: a status report. Trends in parasitology, (2004); 20(10), 477-481.
• Kennedy MW, Harnett W. (Eds.). Parasitic nematodes: molecular biology, biochemistry and immunology, (2013), CABI.
• Kopp SR, Coleman GT, Traub RJ, McCarthy JS, Kotze AC. Acetylcholine receptor subunit genes from Ancylostoma caninum: altered transcription patterns associated with pyrantel resistance. International journal for parasitology, (2009); 39(4), 435-441.
• Köse, M, Kozan E, Sevimli FK, Eser M. The resistance of nematode parasites in sheep against anthelmintic drugs widely used in Western Turkey. Parasitology research, (2007); 101(3), 563-567.
• Kwa MS, Veenstra JG, Roos MH. Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in β-tubulin isotype 1. Molecular and biochemical parasitology, (1994); 63(2), 299-303.
• Lespine A, Alvinerie M, Vercruysse J, Prichard RK, Geldhof P. ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics. Trends in parasitology, (2008); 24(7), 293-298.
• Levecke B, De Wilde N, Vandenhoute E, Vercruysse J. Field validity and feasibility of four techniques for the detection of Trichuris in simians: a model for monitoring drug efficacy in public health. PLoS neglected tropical diseases, (2009); 3(1), e366.
• Love S. Monepantel (Zolvix®) resistance confirmed in goats in NSW Australia. WormMail Newsletter, 6 June 2014.
• Malan FS, Van Wyk JA, Wessels CD. Clinical evaluation of anaemia in sheep: early trials. The Onderstepoort journal of veterinary research, (2001); 68(3), 165.
• Martin PJ, Anderson N, Jarrett RG. Detecting benzimidazole resistance with faecal egg count reduction tests and in vitro assays. Australian Veterinary Journal, (1989); 66(8), 236-240.
• Martin RJ, Robertson AP, Bjorn H. Target sites of anthelmintics. Parasitology, (1997); 114(7), 111-124.
• Martin RJ, Robertson AP. Mode of action of levamisole and pyrantel, anthelmintic resistance, E153 and Q57. Parasitology, (2007); 134(8), 1093-1104.
• McCavera S, Walsh TK, Wolstenholme AJ. Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers. Parasitology, (2007); 134(8), 1111-1121.
• McKellar QA and Jackson F. Veterinary anthelmintics: old and new. Trends in Parasitology, (2004); 20, (10), 456-461.
• Mederos AE, Ramos Z, Banchero, GE. First report of monepantel Haemonchus contortus resistance on sheep farms in Uruguay. Parasites & vectors, (2014); 7(1), 598
• Neveu C, Charvet C, Fauvin A, Cortet J, Castagnone-Sereno P, Cabaret J. Identification of levamisole resistance markers in the parasitic nematode Haemonchus contortus using a cDNA-AFLP approach. Parasitology, (2007); 134(8), 1105-1110.
• Önder Z, Yildirim A, Inci A, Düzlü Ö, Çiloğlu A. Molecular Prevalence, Phylogenetic Characterization and Benzimidazole Resistance of Haemonchus contortus from Sheep. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 22(1), (2016); 93-99.
• Prichard RK and Roulet A. ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker development. Parasitology, (2007); 134(8), 1123-1132.
• Rayes D, De Rosa MJ, Bartos M, Bouzat C. Molecular basis of the differential sensitivity of nematode and mammalian muscle to the anthelmintic agent levamisole. Journal of Biological Chemistry, (2004); 279(35), 36372-36381.
• Roos MH, Kwa MSG, Grant WN. New genetic and practical implications of selection for anthelmintic resistance in parasitic nematodes. Parasitology Today, (1995); 11(4), 148-150.
• Rufener L, Mäser P, Roditi I, Kaminsky R. Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. PLoS pathogens, (2009); 5(4), e1000380.
• Sangster NC and Dobson RJ. Anthelmintic resistance. Taylor & Francis, (2002).
• Sangster NC, Redwin JM, Bjorn H. Inheritance of levamisole and benzimidazole resistance in an isolate of Haemonchus contortus. International journal for parasitology, (1998); 28(3), 503-510.
• Scott I, Pomroy WE, Kenyon PR, Smith G, Adlington B, Moss A. Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis. Veterinary parasitology, (2013); 198(1), 166-171.
• Silvestre A and Cabaret J. Mutation in position 167 of isotype 1 β-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance?. Molecular and biochemical parasitology, (2002); 120(2), 297-300.
• Skuce P, Stenhouse L, Jackson F, Hypša V, Gilleard J. Benzimidazole resistance allele haplotype diversity in United Kingdom isolates of Teladorsagia circumcincta supports a hypothesis of multiple origins of resistance by recurrent mutation. International journal for parasitology, (2010); 40(11), 1247-1255.
• Smith JM and Prichard RK. (2002). Localization of p-glycoprotein mRNA in the tissues of Haemonchus contortus adult worms and its relative abundance in drug-selected and susceptible strains. Journal of Parasitology, 88(3), 612-620.
• Sutherland IA, Leathwick DM. Anthelmintic resistance in nematode parasites of cattle: a global issue. Trends in parasitology, (2011); 27(4), 176-181.
• Taylor MA, Hunt KR, Goodyear KL. Anthelmintic resistance detection methods. Veterinary Parasitology, (2002); 103(3), 183-194.
• Tinar, R, Akyol CV, Cirak VY, Şenlik B, Bauer C. Investigations on the seasonal patterns of strongyle infections in grazing lambs, and the occurrence of anthelmintic resistance on sheep and goat farms in western Anatolia, Turkey. Parasitology research, (2005); 96(1), 18-23.
• Várady M, Čudeková P, Čorba J. In vitro detection of benzimidazole resistance in Haemonchus contortus: egg hatch test versus larval development test. Veterinary parasitology, (2007); (1), 104-110.
• Von Samson-Himmelstjerna G, Blackhall WJ, McCarthy JS, Skuce PJ. Single nucleotide polymorphism (SNP) markers for benzimidazole resistance in veterinary nematodes. Parasitology, (2007); 134 (8), 1077-1086.
• Von Samson-Himmelstjerna G. Molecular diagnosis of anthelmintic resistance. Veterinary parasitology, (2006); 136(2), 99-107.
• Wolstenholme AJ, Fairweather I, Prichard R, von Samson-Himmelstjerna, G, Sangster NC. Drug resistance in veterinary helminths. Trends in parasitology, (2004); 20(10), 469-476.