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Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits

Year 2018, Volume: 11 Issue: 4, 463 - 467, 15.12.2018
https://doi.org/10.30607/kvj.431453

Abstract

This
study aimed to investigate the effects of premedication with ascorbic acid
(vitamin C) on physiologic parameters before medetomidine–ketamine anesthesia
in New Zealand white rabbits. A total of 14 rabbits of both sexes, 1-4 months
of age and 2-4 kg in body weight, were used in this study. The rabbits were
randomly assigned one of two groups: medetomidine–ketamine (MK) or ascorbic
acid–medetomidine–ketamine (AAMK). The rabbits in the MK group were given 0.25
mg/kg of medetomidine and 15 mg/kg of ketamine intramuscularly. The rabbits in
the AAMK group were given 60 mg/kg of vitamin C intramuscularly 20 min prior to
the same dose of medetomidine–ketamine anesthesia. The onset of anesthesia,
time of surgical anesthesia, and total anesthesia time in the two groups was
recorded. Heart rate, respiratory rate, and body temperature were also recorded
at 0, 5, 10, 15, 20, 25, 30, 45 and 60 minutes during anesthesia. Physiologic
parameters were not statistically different between the two groups.
Pretreatment with vitamin C prior to medetomidine–ketamine anesthesia decreased the duration of onset of anesthesia. As a
result, it was concluded that vitamin C can be used prior to anesthesia to
accelerate the effect of medetomidine–ketamine in rabbits.

References

  • REFERENCES1. 1.Blum JR, Daunt DA, Hamm TE, Faroghi A, Birusingh K. Cardio-respiratory effects of medetomidine in rabbits. Vet Surg.. 1992; 21:158.2.Cullen LK. 1996. Medetomidine sedation in dogs and cats: a review of its pharmacology and dose. The British Veterinary Journal. 1996; 152: 519-35.3. Egwu GO, Mshelia GD, Sanni S, Onyeyili PA, Adeyanju GT. The effect of vitamin C at varying times on physiological parameters in rabbits after xylazine anesthesia. Veterinaria Italiana. 2011; 47: 97-104.4. Elsa A, Ubandawaki S. 2005. Ketamine anesthesia following premedication of rabbits with vitamin C. Journal of Veterinary science. 2005; 6: 239-41.5. Flecknell PA. Laboratory Animal Anaesthesia. A Practical Introduction for Research Workers and Technicians. London: Academic Press, 19976. Grint NJ, Murison PJ. A comparison of ketamine-midazolam and ketamne-medetomidine combinations for induction of anaesthesia in rabbits. Veterinary Anaesthesia Analgesia. 2008; 35: 113-121.7. Hedenqvist P, Roughan JV, Orr HE, Antunes LM. Assessment of ketamine/medetomidine anaesthesia in the New Zealand White rabbit. Veterinary Anaesthesia Analgesia. 2001; 28: 18–25.8. Hellebrekers LJ, De Boer EJW, Van Zuylen MA, Vosmeer H. 1997. A comparison between medetomidine-ketamine and medetomidine-propofol anaesthesia in rabbits. Laboratory Animals.1997; 31, 58–69.9. Henke J, Astner S, Brill T, Eissner B, Busch R, Erhardt W. Comparative study of three intramuscular anaesthetic combinations (medetomidine-ketamine, medetomidine-fentanyl-midazolam and xylazine-ketamine) in rabbits. Veterinary Anaesthesia Analgesia. 2005; 32: 261-270.10. Ito J, Otsuki N, Zhang X, Konno T, Kurahashi T, Takahashi M, Yamato M, Matsuoka Y, Yamada K, Miyata S, Fujii J. Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice. Life Science.2014; 95: 1-8.11. Kılıç N. A comparison between Medetomidine-Ketamine and Xylazine-Ketamine Anaesthesia in rabbits. Turkish Journal of Veterinary Animal Sciences. 2004; 28: 921-926.12. Laurence DR, Bennett PN, Brown MJ. Clinical Pharmacology. 8th ed. London: Churchill Livingstone; 1997.13. Lukasik VM. Premedication and sedation. In: Seymour C. & Gleed R. Manual of Small Animal Anesthesia and Analgesia. Cheltenham: BSAVA, pp.71-85, 1999.14. Najafpour A, Sadeghi-Hashjin G. 2007. Vitamin C pre-medication enhances the anaesthetic effect of ketamine-xylazine combination in the rat. Archives of Medical Med Science. 2007; 4: 340-343.15. Nevalainen T, Pyhala L, Voipio, HM,Virtanen R. Evaluation of anaesthetic potency of medetomidine-ketamine combination in rats, guinea-pigs and rabbits. Acta Veterinaria Scandinavic. 1989; 5: 139-143.16. Sauberich H.E. 1994. Pharmocology of vitamin C. Annual Review of Nutrition. 4: 371-391.17. Yanmaz LE, Doğan E, Okumuş Z, Şenoçak MG, Prastiwi A, Yıldırım F. Xylazine-Ketamine Anesthesia Following Premedication of New Zealand White Rabbits with Vitamin C. Journal of the Faculty of Veterinary, Kafkas University. 2016; 22(1): 115-118.

Yeni Zelanda Beyaz Tavşanlarında Medetomidin – Ketamin Anestezisi Öncesi Preanestezik Olarak Vitamin C Kullanılması

Year 2018, Volume: 11 Issue: 4, 463 - 467, 15.12.2018
https://doi.org/10.30607/kvj.431453

Abstract

Bu
çalışmada, beyaz Yeni Zelanda tavşanlarında medetomidin – ketamin anestezisi
öncesi preanestezik olarak uygulanan askorbik asitin (vitamin C=vit )
fizyolojik parametreler üzerine etkisinin araştırılması amaçlanmıştır. Her iki
cinsiyette 1-4 aylık ve 2-4 kg vücut ağırlığında sahip toplam 14 tavşan bu
çalışma için kullanıldı. Tavşanlar rastgele iki gruba ayrıldı; medetomidin –
ketamin (MK) ya da askorbik asit – medetomidin – ketamin (AAMK). MK grubundaki
tavşanlara 0.25 mg/kg medetomidin ve 15 mg/kg ketamin intramuscular olarak
uygulandı. AAMK grubundaki tavşanlara aynı dozdaki medetomidin-ketamin
anestezisinden 20 dk önce 60 mg/kg oranında kas içi C vitamini verildi. İki
grupta anestezi başlangıç zamanı, cerrahi anestezi süresi ve total anestezi
zamanı kaydedildi. Anestezi sırasında kalp oranı, solunum oranı ve vücut
sıcaklığı 0, 5, 10, 15, 20, 25, 30, 45 ve 60 dakikalarda kaydedildi. Fizyolojik
parametreler açısından her iki grupta istatiksel olarak fark belirlenemedi.
Sonuç olarak, tavşanlarda medetomidin – ketamin anestezisi öncesi C vitaminin
kullanılması anestezi giriş süresini kısalttığı görülmüştür.   

References

  • REFERENCES1. 1.Blum JR, Daunt DA, Hamm TE, Faroghi A, Birusingh K. Cardio-respiratory effects of medetomidine in rabbits. Vet Surg.. 1992; 21:158.2.Cullen LK. 1996. Medetomidine sedation in dogs and cats: a review of its pharmacology and dose. The British Veterinary Journal. 1996; 152: 519-35.3. Egwu GO, Mshelia GD, Sanni S, Onyeyili PA, Adeyanju GT. The effect of vitamin C at varying times on physiological parameters in rabbits after xylazine anesthesia. Veterinaria Italiana. 2011; 47: 97-104.4. Elsa A, Ubandawaki S. 2005. Ketamine anesthesia following premedication of rabbits with vitamin C. Journal of Veterinary science. 2005; 6: 239-41.5. Flecknell PA. Laboratory Animal Anaesthesia. A Practical Introduction for Research Workers and Technicians. London: Academic Press, 19976. Grint NJ, Murison PJ. A comparison of ketamine-midazolam and ketamne-medetomidine combinations for induction of anaesthesia in rabbits. Veterinary Anaesthesia Analgesia. 2008; 35: 113-121.7. Hedenqvist P, Roughan JV, Orr HE, Antunes LM. Assessment of ketamine/medetomidine anaesthesia in the New Zealand White rabbit. Veterinary Anaesthesia Analgesia. 2001; 28: 18–25.8. Hellebrekers LJ, De Boer EJW, Van Zuylen MA, Vosmeer H. 1997. A comparison between medetomidine-ketamine and medetomidine-propofol anaesthesia in rabbits. Laboratory Animals.1997; 31, 58–69.9. Henke J, Astner S, Brill T, Eissner B, Busch R, Erhardt W. Comparative study of three intramuscular anaesthetic combinations (medetomidine-ketamine, medetomidine-fentanyl-midazolam and xylazine-ketamine) in rabbits. Veterinary Anaesthesia Analgesia. 2005; 32: 261-270.10. Ito J, Otsuki N, Zhang X, Konno T, Kurahashi T, Takahashi M, Yamato M, Matsuoka Y, Yamada K, Miyata S, Fujii J. Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice. Life Science.2014; 95: 1-8.11. Kılıç N. A comparison between Medetomidine-Ketamine and Xylazine-Ketamine Anaesthesia in rabbits. Turkish Journal of Veterinary Animal Sciences. 2004; 28: 921-926.12. Laurence DR, Bennett PN, Brown MJ. Clinical Pharmacology. 8th ed. London: Churchill Livingstone; 1997.13. Lukasik VM. Premedication and sedation. In: Seymour C. & Gleed R. Manual of Small Animal Anesthesia and Analgesia. Cheltenham: BSAVA, pp.71-85, 1999.14. Najafpour A, Sadeghi-Hashjin G. 2007. Vitamin C pre-medication enhances the anaesthetic effect of ketamine-xylazine combination in the rat. Archives of Medical Med Science. 2007; 4: 340-343.15. Nevalainen T, Pyhala L, Voipio, HM,Virtanen R. Evaluation of anaesthetic potency of medetomidine-ketamine combination in rats, guinea-pigs and rabbits. Acta Veterinaria Scandinavic. 1989; 5: 139-143.16. Sauberich H.E. 1994. Pharmocology of vitamin C. Annual Review of Nutrition. 4: 371-391.17. Yanmaz LE, Doğan E, Okumuş Z, Şenoçak MG, Prastiwi A, Yıldırım F. Xylazine-Ketamine Anesthesia Following Premedication of New Zealand White Rabbits with Vitamin C. Journal of the Faculty of Veterinary, Kafkas University. 2016; 22(1): 115-118.
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Details

Primary Language English
Journal Section RESEARCH ARTICLE
Authors

Rahime Yaygıngül

Zeynep Bozkan This is me

Osman Bulut This is me

Ali Belge This is me

Publication Date December 15, 2018
Acceptance Date September 27, 2018
Published in Issue Year 2018 Volume: 11 Issue: 4

Cite

APA Yaygıngül, R., Bozkan, Z., Bulut, O., Belge, A. (2018). Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits. Kocatepe Veterinary Journal, 11(4), 463-467. https://doi.org/10.30607/kvj.431453
AMA Yaygıngül R, Bozkan Z, Bulut O, Belge A. Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits. kvj. December 2018;11(4):463-467. doi:10.30607/kvj.431453
Chicago Yaygıngül, Rahime, Zeynep Bozkan, Osman Bulut, and Ali Belge. “Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits”. Kocatepe Veterinary Journal 11, no. 4 (December 2018): 463-67. https://doi.org/10.30607/kvj.431453.
EndNote Yaygıngül R, Bozkan Z, Bulut O, Belge A (December 1, 2018) Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits. Kocatepe Veterinary Journal 11 4 463–467.
IEEE R. Yaygıngül, Z. Bozkan, O. Bulut, and A. Belge, “Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits”, kvj, vol. 11, no. 4, pp. 463–467, 2018, doi: 10.30607/kvj.431453.
ISNAD Yaygıngül, Rahime et al. “Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits”. Kocatepe Veterinary Journal 11/4 (December 2018), 463-467. https://doi.org/10.30607/kvj.431453.
JAMA Yaygıngül R, Bozkan Z, Bulut O, Belge A. Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits. kvj. 2018;11:463–467.
MLA Yaygıngül, Rahime et al. “Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits”. Kocatepe Veterinary Journal, vol. 11, no. 4, 2018, pp. 463-7, doi:10.30607/kvj.431453.
Vancouver Yaygıngül R, Bozkan Z, Bulut O, Belge A. Use of Vitamin C for Premedication Prior to Medetomidine–Ketamine Anesthesia in New Zealand White Rabbits. kvj. 2018;11(4):463-7.

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