Antibiotic Resistance of Stenotrophomonas maltophilia Strains Isolated from Horses

Year 2019, Volume: 12 Issue: 4, 384 - 388, 31.12.2019

Uçkun Sait Uçan , Bilal Osamah Mohammed Murat Yiğit

https://doi.org/10.30607/kvj.583479

Abstract

Stenotrophomonas maltophilia
is a member of gamma proteobacteria that has been frequently isolated from
humans as well as from animals. One of the most outstanding feature of S. maltophilia is its antibacterial
resistance that is basicly controlled by various pathways including intrinsic
manner. By this study we aimed to evaluate the interaction of S. maltophilia suspected equine strains
with various antibiotics in the presence of Thymoquinone in vitro. Disc diffusion technique was used for measuring
interactions between the thymoquinone and others. No measurable inhibition zone
for synergistic or antagonistic effect between the thymoquinone and test
antibiotics was observed. However, the thymoquinone itself has an antibacterial
potential.

Keywords

Stenotrophomonas maltophilia, Antibiotic, horse, resistance

Atlardan İzole Edilen Stenotrophomonas maltophilia Suşlarının Antibiyotik Direnci

Abstract

Stenotrophomonas maltophilia
gamma proteobacteria içerisinde yer alan ve hem insanlardan hem de hayvanlardan
sık izole edilen bir bakteri türüdür. S.
maltophilia’nin en dikkat çeken özelliklerinden birisi bakterinin intrinsik
mekanizmalar da dahil olmak üzere çeşitli şekillerde geliştirdiği yüksek
antibiyotik direncidir. Bu çalışma ile atlardan izole edilmiş olan S. maltophilia’nın timokionon ile
çeşitli antibiyotiklerin beraber kullanıldıklarındaki etkileşimini ölçmek
amaçlandı. Ne sinerjizm ne de antogonizm şeklinde bir etkileşim ölçülmedi.
Ancak timokiononun S. maltophilia
suşları üzerinde antibakteriyel etkisi tespit edildi.. 

Keywords

Stenotrophomonas maltophilia, Antibiyotik, at, direnç

References

• Adegoke AA, Stenström TA and Okoh AI. Stenotrophomonas maltophilia as an Emerging Ubiquitous Pathogen: Looking Beyond Contemporary Antibiotic Therapy. Front. Microbiol. 2017; 8:2276. doi: 10.3389/fmicb.2017.02276.
• Çelikel İÜ. Hayvanlar ve çevrelerinden Stenotrophomonas maltophilia izolasyonu ve karakterizasyonu. Ankara Üniversitesi Sağlık Bilimleri Enstitüsü, Doktora Tezi, Ankara. 2012.
• Denton M Kerr KG. Microbiological and clinical aspects of infection associated with Stenotrophomonas maltophilia. Clin Microbiol Rev. 1998; 11: 57-80.
• Halawani E. Anibacterial Activity of Thymoquinone and Thymohydroquinone of Nigella sativa L. And Their Interactions with some Antibiotics. Adv. Biol. Res. 2009; 3(5-6): 148-152.
• Hanafi MS, Hatem ME. Studies on the anti-microbial activity of the Nigella sativa seed (Black Cumin). J Ethnopharmacol. 1991; 34: 275-278.
• Johnson EH, Al-Busaidy R, Hameed MS. An outbreak of lymphadenitis associated with Stenotrophomonas (Xanthomonas) maltophilia in Omani goats. J Vet Med. 2003; 50: 102-104.
• Looney WJ, Narita M, Mu¨hlemann K. Stenotrophomonas maltophilia: an emerging opportunist human pathogen. Lancet Infect Dis.2009; 9, 312–323.
• Muir P, Oldenhoff WE, Hudson AP, Manley PA, Schaefer SL, Markel MD, Hao Z. Detection of DNA from a range of bacterial species in the knee joints of dogs with inflammatory knee arthritis and associated degenerative anterior cruciate ligament rupture. Microb Pathog. 2007; 42: 47-55.
• Ohnishi M, Sawada T, Marumo K, Harada K, Hirose K, Shimizu A, Hayashimoto M, Sato R, Uchida N, Kato H. Antimicrobial susceptibility and genetic relatedness of bovine Stenotrophomonas maltophilia isolates from a mastitis outbreak. LETT APPL MICROBIOL. 2012; 54, 572–576.
• Palleroni NJ. Genus IX. Stenotrophomonas, In: Bergey’s Manual of Systematic Bacteriology 2nd edition, Volume Two The Proteobacteria, Part B The Gammaproteobacteria. Ed; Brenner, DJ, Krieg NR, Staley JT, 2005; pp. 107-115.
• Saddler GS, Bradburry JF. Family I. Xanthomonadaceae fam. nov In: Bergey’s Manual of Systematic Bacteriology 2nd edition, Volume Two The Proteobacteria, Part B The Gammaproteobacteria. Ed; Brenner, DJ, Krieg NR, Staley JT, 2005; pp. 63.
• Sánchez MB. Antibiotic resistance in the opportunistic pathogen Stenotrophomonas maltophilia. Front. Microbiol. 2015. 6:658. doi: 10.3389/fmicb.2015.00658.https://doi.org/10.1155/2019/1528635.
• US Uçan, Z Sayın, A Sakmanoğlu, A Uslu. Effect of thymoquinone on proliferation of bovine peripheral blood mononuclear cells. Eurasian J Vet Sci. 2018; 34:1-6.
• Winther L, Andersen RM, Baptiste, KE, Aalbek B, Guardabassi L. Association of Stenotrophomonas maltophilia infection with lower airway disease in the horse: A retrospective case series. Vet J. 2010; 186: 358-363.
• Yimer EM, Tuem KB, Karim A, Ur-Rehman N, Anwar F. Review Article Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses. J Evid Based Complementary Altern Med. 2019; Article ID 1528635, 16 pages.