Evaluation of Testicular Arterial Doppler Ultrasonography and Spermatological Parameters in Pomeranian Dogs with Alopecia X

Year 2025, Volume: 18 Issue: 1, 25 - 32

Cumali Kaya , Burcu Esin , Çağatay Esin

Abstract

The present study investigates the effects of vascular parameters in testicular vessels on sperm quality in Pomeranian dogs with alopecia X. In the study, Doppler parameters such as peak systolic velocity (PSV, cm/s), end-diastolic velocity (EDV, cm/s), resistive index (RI), and pulsatility index (PI) of testicular arteries were measured in the healthy control group and dogs in the alopecia X group, and motility, progressive motility, and abnormal morphology analyses were performed in semen collected from dogs. When the obtained results were examined, it was determined that RI and PI parameters were higher, and the examined spermatological parameters were significantly lower, in dogs in the alopecia X group compared to the healthy control group (p < 0.05). It is thought that increased RI and PI values may negatively affect spermatogenesis by causing insufficient blood flow in the testicles and that a decrease in sperm motility, progressive motility, and morphological parameters may be related to this situation. The results obtained provide important data on the negative effects of alopecia X on reproductive health and emphasize that this disease should be addressed in male dogs not only in terms of dermatological but also reproductive functions.

Keywords

Alopecia X, Doppler ultrasonography, Sperm evaluation, Testicular artery

Alopecia X'li Pomeranian Köpeklerde Testiküler Arteriyel Doppler Ultrasonografi ve Spermatolojik Parametrelerin Değerlendirilmesi

Abstract

Sunulan çalışma, alopecia X'li pomeranian ırkı köpeklerde testis damarlarındaki vasküler parametrelerin sperm kalitesi üzerindeki etkilerini araştırmayı amaçlamaktadır. Çalışmada sağlıklı kontrol grubu ile alopecia X grubunda bulunan köpeklerde testis arterlerinin pik sistolik hızı (PSV, cm/s), son diyastolik hız (EDV, cm/s), rezistif indeks (RI) ve pulzatilite indeksi (PI) gibi doppler parametreleri ile köpeklerden alınan spermadan motilite, progresif motilite ve anormal morfoloji analizleri yapılmıştır. Elde edilen sonuçlar incelendiğinde alopesi X grubunda bulunan köpeklerin sağlıklı kontrol grubuna kıyasla daha yüksek RI ve PI parametreleri, incelenen spermatolojik parametrelerde ise alopesi x grubunda bulunan köpeklerin sağlıklı kontrol grubuna kıyasla anlamlı derecede daha düşük olduğu belirlenmiştir (p<0,05). Artan RI ve PI değerlerinin testislerde yetersiz kan akışına yol açarak spermatogenezi olumsuz etkileyebileceği, sperma motilitesi, progresif motilite ve morfolojik parametrelerdeki düşüşün de bu durum ile ilişkili olabileceği düşünülmektedir. Elde edilen sonuçlar alopecia X'in üreme sağlığı üzerindeki olumsuz etkilerine dair önemli veriler sağlamaktadır ve bu hastalığın erkek köpeklerde yalnızca dermatolojik değil, aynı zamanda üreme fonksiyonları açısından da ele alınması gerektiğini vurgulamaktadır.

Keywords

Alopesi X, Dopler ultrasonografi, Sperma analizi, Testiküler arter

References

• Abdel-Naser, M. B., & Zouboulis, C. C. (2016). Male fertility and skin diseases. Reviews in Endocrine and Metabolic Disorders, 17, 353-365.
• Bergh, A. (1993). Vascular controls in testicular physiology. Molecular Biology of the Male Reproductive System.
• Biagiotti, G., Cavallini, G., Modenini, F., Vitali, G., & Gianaroli, L. (2002). Spermatogenesis and spectral echo‐colour Doppler traces from the main testicular artery. BJU international, 90(9), 903-908.
• Crawford, M., Lundberg, A., & Neto, R. (2024). Canine alopecia X-Like disorder. Brazilian Journal of Veterinary Pathology, 17(1), 76-78.
• Frank, L. A., Hnilica, K. A., & Oliver, J. W. (2004). Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane. Veterinary Dermatology, 15(5), 278-284.
• Frank, L. A., Hnilica, K. A., Rohrbach, B. W., & Oliver, J. W. (2003). Retrospective evaluation of sex hormones and steroid hormone intermediates in dogs with alopecia. Veterinary Dermatology, 14(2), 91-97.
• Gökalp, G., & Kırbaş, A. (2021). Köpeklerin Atipik Endokrinal Dermatozu, Alopesi X. Firat Universitesi Saglik Bilimleri Veteriner Dergisi, 35(2).
• Güngör, E. S., Güngör, Ş., & Zebitay, A. G. (2016). Assessment of semen quality in patients with androgenetic alopecia in an infertility clinic. Dermatologica Sinica, 34(1), 10-13.
• May, E. R., Frank, L. A., & Sula, M. J. M. (2019). Description and characterization of a hair coat disorder in schipperkes. Veterinary Dermatology, 30(1), 36-e10.
• Ntshingila, S., Oputu, O., Arowolo, A. T., & Khumalo, N. P. (2023). Androgenetic alopecia: An update. JAAD international, 13, 150-158.
• Omu, A. E. (2013). Sperm parameters: paradigmatic index of good health and longevity. Medical Principles and Practice, 22(Suppl. 1), 30-42.
• Price, V. H. (1975). Testosterone metabolism in the skin: a review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens. Archives of Dermatology, 111(11), 1496-1502.
• Rosety, I., Elosegui, S., Pery, M. T., Fornieles, G., Rosety, J. M., Diaz, A. J., & Rosety, M. A. (2014). Association between abdominal obesity and seminal oxidative damage in adults with metabolic syndrome. Revista Medica de Chile, 142(6), 732-737.
• Safarinejad, M. R., Shafiei, N., & Safarinejad, S. (2011). Association of the (TAAAA) n repeat and Asp327Asn polymorphisms in the sex hormone-binding globulin (SHBG) gene with idiopathic male infertility and relation to serum SHBG concentrations. The Journal of Steroid Biochemistry and Molecular Biology, 123(1-2), 37-45.
• Samir, H., Nyametease, P., Nagaoka, K., & Watanabe, G. (2018). Effect of seasonality on testicular blood flow as determined by color Doppler ultrasonography and hormonal profiles in Shiba goats. Animal Reproduction Science, 197, 185-192.
• Scott, D.W., Miller, W.H., & Griffin, C.E. (2001). Endocrine and metabolic diseases. In: Small Animal Dermatology, 6th edn. Philadelphia: W.B. Saunders, 780–885.
• Setchell, B. P. (1990). Local control of testicular fluids. Reproduction, Fertility and Development, 2(3), 291-309. Weller, R. H., John, A., Savin, J., & Dahl, M. (2008). The Function and Structure of Skin. Clinical Dermatology. Ed. by M. Sugden, R. Blundell. 4th ed. Malden, MA: Blackwell Publishing, Inc, 10-33.
• Zelli, R., Troisi, A., Ngonput, A. E., Cardinali, L., & Polisca, A. (2013). Evaluation of testicular artery blood flow by Doppler ultrasonography as a predictor of spermatogenesis in the dog. Research in Veterinary Science, 95(2), 632-637.