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Vitamin D Yetersizliği ve Obezite

Year 2018, Volume: 58 Issue: 2, 108 - 116, 27.12.2018

Arif Altıntaş

Abstract

Bu derleme makalesinde, Vitamin D (Vit D)-obezite ilişkisinin mekanizmasına güncel bilgiler ışığında açıklık getirilmeye çalışılmıştır. Bu ilişki, yağ doku hücrelerinde (adipozit) Vit D reseptörlerinin varlığının gösterilmesi ile başlamıştır. Yağ doku leptin, adiponektin ve resistin gibi hormonları ve TNFα, IL-1β ve IL-6 ve CRP gibi birçok inflamatuar sitokin salgılar. Vit D mezodermal hücrelerin adipozitlere farklılaşması, çoğalması ve olgunlaşması sırasında aracı birçok adipogenik faktörü (adipokin) düzenler. Adipokinler, iştah ve doyma hissi, glikoz ve lipid metabolizması, kan basıncının düzenlenmesi, yangı ve bağışıklık fonksiyonlarını etkiler. Adipozitlerde antiinflamatuar yollar Vit D ile uyarılır. Vit D, yağ dokuda IkB’nin fosforilasyonunu ve NFkB’nin çekirdeğe translokasyonunu inhibe ederek iltihaplanmayı engeller. Obezitede Vit D yağ dokuda aşırı depolanır, deride vitaminin yapımı azalır ve kanda düzeyi düşer. Vit D yetersizliği adipozitlerde lipogenezi uyararak ve Ca akışını sağlayarak dokunun yağlanmasını hızlandırır. Sonuçta yağ doku iltihaplanır ve obezite gelişir. Viseral yağ doku IL, TNF-α, MCP-1 ve resistin gibi inflamatuar adipokinleri salgılayarak hipertansiyon, insulin direnci, diyabet ve Vit D’nin metabolik anormalliklerine yol açar. 

Keywords

Obezite vitamin D vitamin D yetersizliği

References

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Year 2018, Volume: 58 Issue: 2, 108 - 116, 27.12.2018

Arif Altıntaş

Abstract

References

  • 1. Adams JS, Hewison M ( 2010). Update in vitamin D. The Journal of Clinical Endocrinology and Metabolism. 95 (2):471-78.
  • 2. Anonim (2015). “About Vitamin D”. University of California, Riverside. November 2011. Retrieved January 24, 2015.
  • 3. Anonim (2017). Kedi ve Köpeklerde Obezite. http://www.floryahayvanhastanesi.com/pet-kutuphane/kedi-ve-kopeklerde-obezite. Erişim tarihi: 28.04.2017.
  • 4. Antuna-Puente, B.; Feve, B.; Fellahi, S.; Bastard, J.P. Adipokines: The missing link between insulin resistance and obesity. Diabetes Metab. 2008, 34, 2–11.
  • 5. Balistreri CR, Caruso C and Candore G (2010). The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases. Hindawi Publishing Corporation. Mediators of Inflammation. Volume 2010, Article ID 802078, 19 pages. doi:10.1155/2010/802078.
  • 6. Bell N.H., Shaw S., Turner RT (1984). Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. J. Clin. Invest.74: 1540–1544.
  • 7. Bell TD, Demay MB, Burnett-Bowie SA (2010). The biology and pathology of vitamin D control in bone. Journal of Cellular Biochemistry. 111 (1): 7–13.
  • 8. Bland IM, Guthrie-Jones A, Taylor RD, Hill J (2010). Dog Obesity: Veterinary Practices’ and Owners’ Opinions on Cause and Management Prev Vet Med 94 (3-4), 310-315.
  • 9. Bouillon R, Van Cromphaut S, Carmeliet G (2003). Intestinal calcium absorption: Molecular vitamin D mediated mechanisms. Journal of Cellular Biochemistry. 88 (2): 332–339.
  • 10. Canto, C.; Gerhart-Hines, Z.; Feige, J.N.; Lagouge, M.; Noriega, L.; Milne, J.C.; Elliott, P.J.; Puigserver, P.; Auwerx, J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009, 458, 1056–1060.
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  • 14. Chang YC, Hee SW, Hsieh ML, Jeng YM, Chuang LM (2015). The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment. Anal Cell Pathol (Amst) 2015: 972891. http://dx.doi.org/10.1155/2015/972891.
  • 15. Chang E, Kim Y (2017). Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/ SIRT1 Activity in Obese Rats. Nutrients 2017, 9, 338; doi:10.3390/ nu9040338. www.mdpi.com/journal/nutrients.
  • 16. de Souza WN, Martini LA (2015). The role of Vitamin D in obesity and inflammation at adipose tissue. J Obes Metab Res. 2: 161-166.
  • 17. Dinca M, Serban M, Sahebkar A, Mikhailidis D, Toth P, Martin S, et al (2016). Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and metaanalysis of randomized controlled trials. Pharmacol Res.107:360-71
  • 18. Ding C, Gao D, Wilding J, Trayhurn P and Bing C (2012). Horizons in Nutritional Science. Vitamin D signalling in adipose tissue. Br J Nutr. 108 (11):1915-1923.
  • 19. Fontana, L.; Eagon, J.C.; Trujillo, M.E.; Scherer, P.E.; Klein, S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007, 56, 1010–1013.
  • 20. Gaidhu, M.P.; Anthony, N.M.; Patel, P.; Hawke, T.J.; Ceddia, R.B. Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: Role of ATGL, HSL, and AMPK. Am J Physiol. Cell. Physiol. 2010, 298, C961–C971.
  • 21. Galic, S.; Fullerton, M.D.; Schertzer, J.D.; Sikkema, S.; Marcinko, K.;Walkley, C.R.; Izon, D.; Honeyman, J.; Chen, Z.P.; van Denderen, B.J.; et al. Hematopoieti-educes mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Investig 2011, 121, 4903-4915.
  • 22. Gallagher JC, Sai A, Templin I, Thomas Smith L (2012). Dose Response to Vitamin D Supple- mentation in Postmenopausal Women. A Randomized Trial. Ann Intern Med.156 (6):425-437
  • 23. Gao D, Trayhurn P, Bing C (2013). 1,25-dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes, 37, 357- 365.
  • 24. Gauthier MS, O’Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N (2011). Decreased AMPactivated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem. Biophys. Res. Commun., 404, 382–387.
  • 25. Gesta S, Tseng YH and Kahn CR (2007). Developmental origin of fat: tracking obesity to its source. Cell, 131 (2): 242–256.
  • 26. Ghavamzadeh S, Mobasseri M, Mahdavi R (2014). The Effect of Vitamin D Supplementation on Adiposity, Blood Glycated Hemoglobin, Serum Leptin and Tumor Necrosis Factor-α in Type 2 Diabetic Patients. Int J Prev Med,.5 (9): 1091–1098.
  • 27. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S et al.. (2011). Sirt1 regulates adipose tissue inflammation. Diabetes 60, 3235– 3245.
  • 28. Goldner WS, Stoner JA, Thompson J, Taylor K, Larson L, Erickson J, McBride C (2008). Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: A comparison with nonobese controls. Obes. Surg. 18,145-150.
  • 29. Gonzalez-Molero I, Rojo-Martinez G, Morcillo S, Gutierrez C, Rubio E, Perez-Valero V, Esteva I, Ruiz de Adana MS, Almaraz MC, Colomo N et al.. (2013). Hypovitaminosis D and incidence of obesity: A prospective study. Eur J Clin Nutr 67, 680–682.
  • 30. Holick MF (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American Journal of Clinical Nutrition. 80 (6 Suppl): 1678S–1688S.
  • 31. Jonas MI, Kurylowicz A, Bartoszewicz Z,Lisik W,Jonas M,Wierzbicki Z et al (2015). Interleukins 6 and 15 Levels Are Higher in Subcutaneous Adipose Tissue, but Obesity Is Associated with Their Increased Content in Visceral Fat Depots. Int J Mol Sci. 16(10): 25817–25830.
  • 32. Kershaw EE, Flier JS (2004). Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 89 (6): 2548-2556.
  • 33. Kong J., Li YC (2006). Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3t3-l1 cells. Amer. J. Physiol. Endocrinol. Metab. 290: E916 – E924.
  • 34. Koszowska A, Nowak J, Dittfeld A, Brończyk-Puzoń A, Kulpok A, Zubelewicz-Szkodzińska B (2014). Obesity, adipose tissue function and the role of vitamin D. Cent Eur J Immunol. 2:260-264
  • 35. Laflamme DP (2012). Companion Animals Symposium: Obesity in dogs and cats: What is wrong with being fat? J. Anim. Sci. 2012.90:1653–1662.
  • 36. Lago F, Dieguez C, Gómez-Reino J and Gualillo O (2007). Adipokines as emerging mediators of immune response and inflammation. Nature Clinical Practice Rheumatology, 3 (12): 716–724.
  • 37. Lorente-Cebrian S, Eriksson A, Dunlop T, Mejhert N, Dahlman I, Astrom G, Sjolin E, Wahlen K, Carlberg C, Laurencikiene J et al.. (2012). Differential effects of 1 alpha, 25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur. J. Nutr. 2012, 51, 335–342.
  • 38. Maggi S, Siviero P, Brocco E, Albertin M, Romanato G, Crepaldi G (2013). Vitamin D deficiency, serum leptin and osteoprotegerin levels in older diabetic patients: an input to new research avenues. Acta Diabetol. 51 (3): 461–469.
  • 39. Mutt SJ, Karhu T, Lehtonen S, Lehenkari P, Carlberg C, Saarnio J, Sebert S, Hypponen E, Jarvelin MR, Herzig KH (2012). Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D (3) via the NF-κB pathway. FASEB J. 26, 4400-4407.
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Primary Language Turkish
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Authors

Arif Altıntaş This is me 0000-0002-4893-7850

Publication Date December 27, 2018
Published in Issue Year 2018 Volume: 58 Issue: 2

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APA Altıntaş, A. (2018). Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 58(2), 108-116.
AMA Altıntaş A. Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. December 2018;58(2):108-116.
Chicago Altıntaş, Arif. “Vitamin D Yetersizliği Ve Obezite”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 58, no. 2 (December 2018): 108-16.
EndNote Altıntaş A (December 1, 2018) Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 58 2 108–116.
IEEE A. Altıntaş, “Vitamin D Yetersizliği ve Obezite”, Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, vol. 58, no. 2, pp. 108–116, 2018.
ISNAD Altıntaş, Arif. “Vitamin D Yetersizliği Ve Obezite”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 58/2 (December 2018), 108-116.
JAMA Altıntaş A. Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2018;58:108–116.
MLA Altıntaş, Arif. “Vitamin D Yetersizliği Ve Obezite”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, vol. 58, no. 2, 2018, pp. 108-16.
Vancouver Altıntaş A. Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2018;58(2):108-16.